
House vacation rentals in La Mesa
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Top-rated house rentals in La Mesa
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa house rentals
House rentals with a hot tub

Stylish 4BR HOUSE in the ❤️ of San Diego +A/C Spa

Your Modern Lux Pool Resort in the Heart of SD

Cute PB Beach House with Yard & Private Hot Tub

Modern Home - Rooftop Hot Tub with Ocean Views!

University Heights Oasis Getaway

Luxury 4-Bed Home - Amazing Views Only 15m from DT

Luxury Getaway•Hot Tub Harbor Views•Chef’s Kitchen

Entire Home Retreat* Private Pool & Hot Tub
House rentals with a pool

3 BR Urban Oasis with Pool and Spa in Great Area

Private 3 bedroom block to Bay New Pool Spa, Bikes

San Diego Retreat / Cal King x 2 / Pool, Parking!

Lionhead - Private Boutique Home

Bright and spacious home with views, pool & spa.

Centrally located Home w/Guest House, Pool & Spa!

Modern Oasis - Pool, Spa, Great Location 5BR/4BA

Upscale Resort House /Views, Saltwater Pool/Spa !
House rentals with free parking

Modern Bungalow * Entire Home * Excellent Location

Ac home with lots outside space

Pacific Beach Bungalow - Steps from Mission Bay!

Stunning Ocean Beach Gem - has everything!

Cozy 2Bed-Private Parking, Dog Friendly, Big Yard!

Hillcrest 2 bed 2 en-suite baths garage zen garden

4. Family Reunion Historic Sherman Height

🌵King Bed | Queen bed | Full Kitchen | W & D | 1.5Bath | 🌵
Quick stats about house rentals in La Mesa
Total rentals
290 properties
Total number of reviews
12K reviews
Family-friendly rentals
180 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
70 properties have a pool
Rentals with dedicated workspaces
170 properties have a dedicated workspace
Destinations to explore
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- Rosarito Beach
- Oceanside City Beach
- Belmont Park
- Tijuana Beach
- Pacific Beach
- Torrey Pines State Beach
- Coronado Beach
- La Misión Beach
- Coronado Shores Beach
- Oceanside Harbor
- SeaWorld San Diego
- South Coronado Beach
- Black's Beach
- University of California San Diego
- LEGOLAND California
- Balboa Park
- San Diego Zoo Safari Park
- Pechanga Resort Casino
- Playas Los Buenos
- Moonlight Beach
- Liberty Station
- Sesame Place San Diego
- USS Midway Museum
- Hillcrest
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