House vacation rentals in La Mesa

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Top-rated house rentals in La Mesa

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Guest favorite

A spacious outdoor area features a swimming pool, accompanied by colorful lounge chairs and a large umbrella for shade. A unicorn float is visible in the water, with potted flowers adding a touch of vibrancy. The home's façade offers multiple windows and seating options nearby.

Home in La Mesa

4.99 out of 5 average rating, 163 reviews

Mid-Century Style Family House with Spa

Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas, Desert Inn 3/4 acre.Less than 20 minute drive to beaches/Zoo/Sea World/Downtown, 40 minutes to Legoland. With a swimming pool/hot tub, huge lawn surrounded by California Oak/orange/lemonpomegranate trees and herb garden, this home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. No loud parties please, this is a quite community.

Guest favorite

A spacious backyard is visible, featuring a large green lawn surrounded by low hedges. Comfortable seating areas are arranged around a fire pit, complemented by a shaded tree. A detached garage and a shed are seen in the background, against a clear blue sky.

Home in La Mesa

4.91 out of 5 average rating, 101 reviews

Fun Family Vibe Large Private Yard Free Parking

Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

Guest favorite

The property features a spacious backyard with a heated pool surrounded by lounge chairs. Palm trees line the perimeter, and soft lighting illuminates the outdoor area during sunset. The two-story house overlooks the pool, creating an inviting atmosphere for relaxation and gatherings.

Home in La Mesa

4.96 out of 5 average rating, 188 reviews

XTRA 10% OFF until June: Heated pool, outdoor fire

Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our warm pool year-round, roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can sleep 6. But we can provid

Superhost

The interior of the studio showcases a spacious layout, featuring a king size bed adorned with yellow and white pillows. A dark gray sofa complements the decor, facing a coffee table with a plant. Large glass doors provide a view of the garden and outdoor seating.

Home in La Mesa

4.9 out of 5 average rating, 244 reviews

Hidden King Suite with Garden, Parking - 4 Guest

Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Guest favorite

A spacious outdoor area features a clear blue pool surrounded by palm trees. Lounge chairs are positioned nearby, and a shaded table with chairs offers a spot for relaxation. The backyard showcases a privacy fence and ample sunlight.

Home in La Mesa

4.85 out of 5 average rating, 194 reviews

Sunny SD l Pool l BBQ l Pool Loungers l Sleeps 10

Escape to a fresh 4-bedroom retreat for family and friends (10 ppl max). Updated in January of 2024 with new furniture, and fixtures. Bask in the sun on the deck, take a dip in the pool. Enjoy the private and fenced backyard, BBQ, or the recently renovated and modern Kitchen. This home is perfect for vacations or remote work. Explore San Diego beaches and all the area has to offer, the most popular tourist destinations are all within a 20-30 minute drive. 20 minutes to the beach! Book with us!

Top guest favorite

An outdoor patio area features a round table with four chairs, all adorned with colorful cushions. A large red umbrella provides shade, and a decorative rug adds vibrancy to the stone surface. Surrounding greenery and blooming plants create a serene environment.

Home in La Mesa

4.98 out of 5 average rating, 310 reviews

Travel Writer's Pad

Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Superhost

The kitchen area features modern black cabinetry and stainless steel appliances, including a microwave and compact refrigerator. A smart TV is mounted on the wall, complementing the wooden counter workspace equipped with essential cooking utensils. A dining table with two chairs is positioned nearby.

Home in La Mesa

4.86 out of 5 average rating, 219 reviews

Newer "Manor Studio"

Centrally located in San Diego County this newer studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

Top guest favorite

A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.

Home in La Mesa

4.94 out of 5 average rating, 217 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Top guest favorite

A colorful studio space features turquoise walls and a ceiling fan. A comfortable sofa with decorative pillows is paired with a coffee table. A bed with a floral-patterned comforter sits against a window, while a TV and white refrigerator complete the modern setup.

Home in La Mesa

4.99 out of 5 average rating, 243 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Guest favorite

Home in La Mesa

4.92 out of 5 average rating, 126 reviews

(Relist!) Relax at a Stunning 1931 Historic Tudor!

Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.

Guest favorite

A light-filled living space features a white sofa adorned with colorful cushions and a patterned throw. A framed image of a cow's head hangs on a yellow and white accent wall. A small table sits nearby with a potted plant, complementing the minimalist design.

Home in Lemon Grove

4.95 out of 5 average rating, 190 reviews

NEW- King Bed: Very clean, Quiet, A/C, parking

Enjoy a stylish experience at this centrally-located place. Kick back and relax in this calm, stylish suburban feel home near major local attractions. 15 minutes from downtown 15 minutes from the party scene 17 minutes from San Diego zoo 18 minutes from beaches 20 minutes from sea world 20 mins from Coronado CA 23 mins from the Mexico port of entry 40 MIN TO SAFARI ZOO 40 minutes from Legoland 1 hr to the desert 1.5 hrs to LA Near everything yet far away from city chaos

Guest favorite

A bright living area features a cozy sofa centered on a light rug, complemented by large windows that invite natural light. Warm wooden accents are present, including a stylish bookshelf displaying decorative items. A retro-style lamp and simple furnishings create a relaxed atmosphere.

Home in La Mesa

4.9 out of 5 average rating, 105 reviews

Gorgeous Family Retreat | Games, FirePit & Parking

Located within the desirable Helix Hills neighborhood is this spacious family home with room for everyone to relax, unwind, and be entertained. The home features multiple living areas, a gourmet kitchen, a foosball table, 5 beautifully furnished bedrooms and an expansive outdoor area with a fire pit, an outdoor lounge and an elevated balcony with mountain views. You'll be only minutes from shopping centers and only 15 mins to the heart of San Diego and all its attractions.