Guesthouse vacation rentals in La Mesa
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Top-rated guesthouse rentals in La Mesa
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa guesthouse rentals
Family-friendly guest house rentals
Guesthouse in San Diego
4.97 out of 5 average rating, 506 reviewsCentral & Serene Secret Garden Guesthouse
Oct 15 – 22
Guesthouse in San Diego
4.97 out of 5 average rating, 292 reviewsPrivate Guest House with a View
Aug 6 – 13
Guesthouse in San Diego
4.99 out of 5 average rating, 364 reviews*Private Canyon Retreat: Your Own Guesthouse*
Oct 7 – 14
Guesthouse in San Diego
4.96 out of 5 average rating, 251 reviewsYour Kensington Bungalow
Sep 27 – Oct 4
Guesthouse in Chula Vista
4.95 out of 5 average rating, 475 reviewsPrivate Casita in Great Eastlake Neighborhood
Oct 17 – 24
Guesthouse in San Diego
4.93 out of 5 average rating, 447 reviewsPrivate Cottage in Walkable North Park w/AC
May 31 – Jun 7
Guesthouse in San Diego
4.92 out of 5 average rating, 366 reviewsCozy 1-bdr apt in Normal Heights near Adams Ave
Jan 8 – 15
Guesthouse in San Diego
4.96 out of 5 average rating, 211 reviewsNorth Park, San Diego's Best At Your Doorstep
Jun 3 – 10
Guest house rentals with a patio
Guesthouse in San Diego
4.99 out of 5 average rating, 107 reviewsModern Guest House with Patio, Parking, & Laundry
Jun 5 – 12
Guesthouse in San Diego
4.99 out of 5 average rating, 151 reviewsAdorable cottage in Talmadge
Aug 4 – 11
Guesthouse in La Mesa
4.97 out of 5 average rating, 117 reviewsSan Diego Newly Built Private Guesthouse (Sleep 5)
Jul 7 – 14
Guesthouse in San Diego
4.93 out of 5 average rating, 122 reviewsModern Guest House with pool, steps to SDSU
Oct 7 – 14
Guesthouse in San Diego
4.85 out of 5 average rating, 124 reviewsPrivate, beautiful 1-bedroom 2 story guest house
Aug 15 – 22
Guesthouse in Spring Valley
4.97 out of 5 average rating, 111 reviewsLoft Cabin-Night Cinema+Hot Soaking Tub+Views!
Jun 8 – 15
Guesthouse in San Diego
4.93 out of 5 average rating, 147 reviewsCentral studio w/ private outdoor space & parking
Mar 23 – 30
Guesthouse in San Diego
4.98 out of 5 average rating, 123 reviewsPrivate Studio Cottage with Outdoor Patio
Dec 11 – 18
Guest house rentals with a washer and dryer
Guesthouse in San Diego
4.96 out of 5 average rating, 117 reviews1BR Casita in the Heart of Kensington!
Sep 3 – 10
Guesthouse in San Diego
4.95 out of 5 average rating, 107 reviewsRelax in a Centrally Located, Modern Guest House
Jan 12 – 19
Guesthouse in San Diego
4.98 out of 5 average rating, 185 reviewsNorth Park Garden Retreat Casita
Sep 8 – 15
Guesthouse in El Cajon
4.99 out of 5 average rating, 152 reviewsModern mountain guest house. Incredible views
Nov 20 – 27
Guesthouse in Lemon Grove
4.89 out of 5 average rating, 163 reviews"Glam Farmhouse dream cottage"🏠🌠
Aug 18 – 25
Guesthouse in El Cajon
4.96 out of 5 average rating, 131 reviewsMt Helix Studio Loft with Mountain Views
Oct 15 – 22
Guesthouse in San Diego
4.98 out of 5 average rating, 205 reviewsOur Garden Cottage: A home away from home.
Dec 22 – 29
Guesthouse in San Diego
4.84 out of 5 average rating, 213 reviewsCozy Cottage
Jun 8 – 15
Quick stats about guesthouse rentals in La Mesa
Total rentals
60 properties
Wifi availability
60 properties include access to wifi
Rentals with dedicated workspaces
30 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Total number of reviews
3.9K reviews
Nightly prices starting at
$50 before taxes and fees
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