
Vacation rentals in La Mesa
Book unique vacation rentals, houses, and more on Airbnb
Top-rated vacation rentals in La Mesa
Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa vacation rentals
Other great vacation rentals in La Mesa

921 Beach Cottage-Hottest location in San Diego
This was such a cute little house in a great location. There are restaurants, bars, shops, and the best part is the beach that are all a very easy, short walk away. Can’t beat this location! And they have tons of recommendations for places close by. Would definitely stay here again in the future.

Swanky Casa Ocean Beach 1 Blk to Beach w A/C
Absolutely loved stay at Joshua’s bungalow! It is cute & beautiful, clean, perfect location, patios are lush. It was great for our group! Notes- know youre in the war zone, it’s not that bad to us, and worth it, quiets down at like 10. Know this is a jack & jill arrangement with pocket doors- be sure youre close with your bunk mates, if you know what im saying! Also note youre in San Diego beachside- it can be rainy/misty in the mornings- the patio furniture can get wet- dont forget to wipe down! Plenty of towels. The beach is a block or so, the main drag is also a block or so- all the restaurants and shopping you can imagine! So nice to be right in the middle of it all. We had an absolute blast! Definitely will be returning soon (:

Charming Coastal Cottage Windansea Beach Walkable
We had a great three-night stay at this home with our toddler and infant. The house was very clean and well-equipped with thoughtful amenities for kids, including a high chair, pack-and-play, and even beach toys, which came in handy. The backyard was a relaxing spot to unwind, and the location was convenient to everything we wanted to do. The hosts were friendly and very responsive, which we really appreciated. We’d definitely recommend this place to other families.

Mission Beach Family Paradise. Beach & Bay fun
We had such a great time at this beach rental in Mission Bay! Mark was an incredibly kind and accommodating host—quick to respond whenever we needed anything. The space was clean, well-stocked, and perfect for families. Our three-year-old was in heaven with all the toys and beach gear available—it made our stay so much more relaxing. The location couldn’t have been better—just a few steps from Mission Bay, which made entertaining the kids super easy. We spent our days going back and forth from the sand to the rental with zero hassle. Another big plus was the checkout process. Unlike other Airbnbs with long, detailed lists of things to do, Mark’s checkout instructions were short, simple, and easy to follow. All in all, it was a fantastic stay. We’re already hoping to come back next year!

NEW Steps to Sand Cozy 2 Bdrm for 6 w/office area
My husband and I had a great stay! It’s steps from the beach and super walkable. Cute & clean place. Pay attention to the host’s parking instructions! Parking in mission beach is tricky, but they do their best to accommodate their guests.

Pippi's Paradise cottage 1 block to the beach w/AC
Perfect little hidden gem. Easy one block walk to the beach. Not far from downtown OB and all the restaurants. Rental unit was amazing and included a garage. Unit had every amenity needed. I was very happy with my stay and would definitely rent again.

Beach Shag * Footsteps from the Sand + Bikes
Great place and great host. Would definitely stay here again. It’s small and cozy just like description says. Just a block away from the beach and plenty of restaurants around. The host was very responsive and accommodating.

Updated TownHome, Great Location, Fantastic Views
Jeff’s place was in a great location in the middle of San Diego. The place was immaculate. He obviously is serious about the upkeep of his property and the happiness of his guests. I contacted him that we would be arriving pretty late on our first night so he made sure to leave the light on for us. Entry was always easy with the electronic locking system. Water pressure in the showers was awesome and we wanted for nothing. Thanks Jeff!
Quick stats about vacation rentals in La Mesa
Total rentals
540 properties
Total number of reviews
27K reviews
Family-friendly rentals
250 properties are a good fit for families
Pet-friendly rentals
170 properties allow pets
Rentals with a pool
140 properties have a pool
Rentals with dedicated workspaces
310 properties have a dedicated workspace
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in La Mesa?
Yes! Work meets play with ease at over 310 vacation rentals in La Mesa featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there pet-friendly vacation rentals in La Mesa?
Four-legged friends are welcome in La Mesa. Choose from more than 170 vacation rentals for guests traveling with pets.
How much does it cost to stay in villa rentals in La Mesa?
Experience the best of La Mesa with our villa rentals, starting at about $50 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there La Mesa vacation rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 140 vacation homes with pools in La Mesa, available on Airbnb. Make a splash and soak up the sun in style!
Do house rentals in La Mesa have a bbq area?
Absolutely! We offer over 50 house rentals with a bbq area in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in La Mesa have a gym?
Absolutely! We offer over 30 house rentals with a gym in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in La Mesa have self check-in?
Absolutely! We offer over 50 house rentals with self check-in in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Do condo rentals in La Mesa have wifi?
Absolutely! We offer over 10 condo rentals with wifi in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly house rentals in La Mesa?
La Mesa has more than 180 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
What are the most popular amenities for House Rentals in La Mesa?
Enhance your stay in our House Rentals with the most popular amenities: over 30 homes with a gym, over 50 homes with self check-in, over 50 homes with a bbq area, over 290 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.
Destinations to explore
- San Diego Vacation rentals
- La Joya Vacation rentals
- Palm Springs Vacation rentals
- Anaheim Vacation rentals
- Stanton Vacation rentals
- Los Angeles Vacation rentals
- San Fernando Valley Vacation rentals
- Channel Islands of California Vacation rentals
- Southern California Vacation rentals
- Las Vegas Strip Vacation rentals
- Henderson Vacation rentals
- Las Vegas Vacation rentals
- Rentals with a beach view La Mesa
- Rentals with a washer and dryer La Mesa
- Rentals with an EV charger La Mesa
- Rentals with a fireplace La Mesa
- Smoking-friendly rentals La Mesa
- Rentals with beach access La Mesa
- Rentals with breakfast La Mesa
- Kid-friendly rentals La Mesa
- House rentals La Mesa
- Apartment rentals La Mesa
- Fitness-friendly rentals La Mesa
- Rentals with a hot tub La Mesa
- Private suite rentals La Mesa
- Guesthouse rentals La Mesa
- Rentals with a fire pit La Mesa
- Rentals with outdoor seating La Mesa
- Pet-friendly rentals La Mesa
- Family-friendly rentals La Mesa
- Rentals with a patio La Mesa
- Rentals with pools La Mesa
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Rosarito Beach
- Oceanside City Beach
- Tijuana Beach
- Torrey Pines State Beach
- Pacific Beach
- Coronado Beach
- La Misión Beach
- Coronado Shores Beach
- Oceanside Harbor
- SeaWorld San Diego
- South Coronado Beach
- Black's Beach
- University of California San Diego
- LEGOLAND California
- San Diego Zoo Safari Park
- Balboa Park
- Belmont Park
- Pechanga Resort Casino
- Playas Los Buenos
- Liberty Station
- Moonlight Beach
- Sesame Place San Diego
- Playa Popotla
- USS Midway Museum
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes