House vacation rentals in Seneca

Find and book unique houses on Airbnb

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Popular amenities for Seneca house rentals

House rentals with a pool

Top guest favorite
Home in Salem
4.98 out of 5 average rating, 130 reviews

Keowee Key Luxury Condo - Stunning Views!

BaileyRating, 5 stars2 weeks ago
Wonderful place, beautiful view, absolutely gorgeous apartment. I would definitely stay here again and again.
Top guest favorite
Home in Westminster
4.99 out of 5 average rating, 121 reviews

Lakefront Oasis, Dog-Friendly Fenced in Yard.

CharlotteRating, 5 stars2 days ago
I couldn't be more pleased with my first AirBnB stay. The place was clean, inviting, and well-stocked. I wasn't expecting spices, dog toys, dog bowls, dog cot, etc. The fully fenced in yard, lake access, available kayaks, and privacy are the only things I wanted and this place sure supplied! the hot tub, outdoor shower, and firepit were huge bonuses. Also, met and talked with the neighbor who is super friendly šŸ˜‰ I stayed alone the first half with my dogs and got my peace in. The second half a couple girl friends joined and we thoroughly enjoyed paddling out the this little island and throwing rocks, trying to fish, etc. Enjoying using the coloring supplies, games, and grill as well! It did storm most of the week, but even that was enjoyable! 10/10 experience for us all.
Guest favorite
Home in Greenville
4.92 out of 5 average rating, 63 reviews

10 minutes to downtown. Hot tub & billard room

KristenRating, 5 stars2 weeks ago
Couldn’t recommend this house enough for groups/families! We had the best time. Everyone had their own space, the living area was so spacious and accommodating and the pool/hottub/deck was amazing. Location is convenient to downtown Greenville, but so nice to be a little more tucked away with some peace and privacy. We thought it was even nicer than the photos! Hosts are very helpful and responsive. 10/10!
Guest favorite
Home in Martin
4.88 out of 5 average rating, 34 reviews

Lake Hartwell: Private Pool, Dock, Pets, Fire Pit

IvoryRating, 5 stars4 days ago
Such a beautiful home and place. We enjoyed the stay! The pool was by far our favorite just wish we had better weather to enjoy it further. Great customer service. We accidentally set the fire alarm off one night and she didn’t hesitate to message to make sure everything was okay.
Guest favorite
Home in West Union
4.95 out of 5 average rating, 151 reviews

Sunsets and Siestas -Lake Keowee home near Clemson

AmandaRating, 5 stars1 week ago
We loved this house. Plenty of room for everyone. Enjoyed the house so much, we didn't want to leave! Will be looking into future bookings!
Superhost
Home in Greenville
4.82 out of 5 average rating, 101 reviews

Pet + Family Friendly 4BR Pool House Near Furman

KamyRating, 5 stars1 week ago
We enjoyed this home. It was comfortable, roomy, and suited our needs perfectly. It looked like the pictures. Renee was a great host with checking in on us and making sure everything was good. We would definitely consider staying again!
Guest favorite
Home in Greenville
4.97 out of 5 average rating, 29 reviews

Pet-friendly, pool, Apt, firepit, 3 min to Furman

DaleRating, 5 stars1 month ago
Great place for a large family. Our family of 13 stayed here in April and had a great time. Weather was decent still a little chilly for the pool but the kids loved it anyways. The back yard is beautiful love the fire pit. The guest house was nice to have it was private but still attainable to the family. House was well stocked with towels and linens coffee and essentials like laundry soap. Would highly recommend.
Top guest favorite
Home in Highlands
4.95 out of 5 average rating, 103 reviews

Mountain Laurel Retreat

LynnRating, 5 stars3 weeks ago
Very pleased with the cleanliness & accommodations. Lovely home!

Weekly house rentals

Guest favorite
Home in Lavonia
4.97 out of 5 average rating, 125 reviews

The Skyline Way Lake House w/ Hot Tub & Dock!

BrookeRating, 5 stars5 days ago
We had a great quick trip to Lake Hartwell! The lake house we stayed at on Skyline Way was beautiful. Well kept and had enough amenities to keep everyone in our big family busy. Great view, beautiful dock, large hot tub, game room, paddle boards, kayak, multiple fire pits, theater room, and tons of seating throughout. The weather wasn't the greatest, but we got to spend quality time together. We will definitely book this house again!
Top guest favorite
Home in Anderson
4.97 out of 5 average rating, 111 reviews

Sunset Point-Best view on Broadway - HOT TUB!

CarolinaRating, 5 stars1 week ago
We had an absolutely wonderful stay at this Airbnb over Memorial Day weekend. The home was spotless, beautifully decorated, and equipped with everything we needed for a comfortable and relaxing getaway. What really made the experience special was how well-stocked the place was for fun and adventure—there was a jacuzzi for unwinding in the evenings, plus paddles and kayaks that made it easy to enjoy the water just steps away. The host was incredibly thoughtful and made the entire process seamless from check-in to check-out. With peaceful surroundings and all the amenities you could ask for, this place truly felt like a home away from home. We can’t wait to come back and highly recommend it to anyone looking for the perfect mix of relaxation and outdoor fun.
Superhost
Home in Anderson
4.85 out of 5 average rating, 205 reviews

Lake Living with Amazing Views of Lake Hartwell

TracyRating, 5 stars3 weeks ago
We had a lovely stay at Rhonda's place. She was very responsive to our needs. Easy drive to Clemson University. Place was clean and tidy. Went for some walks and checked out the surroundings, beautiful area. Even met some neighbors who were very nice. Highly recommend staying at Rhonda's home.
Guest favorite
Home in Anderson
4.96 out of 5 average rating, 113 reviews

Clemson ,Lake Hartwell, Waterfront, pontoon rental

ShefiekaRating, 5 stars2 weeks ago
10/10 definitely recommend! This home is perfect for your next family gathering! Tina is amazing definitely would book again should I come back to that area!
Guest favorite
Home in Hartwell
4.93 out of 5 average rating, 123 reviews

Lake house waterfront, 10 min to downtown w Kayaks

DanaRating, 5 stars2 weeks ago
We had a wonderful stay at Dan’s place. Very peaceful and everything was clean. I would highly recommend this stay!
Superhost
Home in Lavonia
4.87 out of 5 average rating, 126 reviews

Retreat on Lake Hartwell, THE BEST DOCK, Sleeps 8!

GrantRating, 5 stars1 month ago
The dock was 100% awesome! Even though the weather wasn’t great, we were still able to enjoy our time on the dock on the lake. The house was as described, and had all the things we needed for the weekend.
Guest favorite
Home in Easley
4.92 out of 5 average rating, 190 reviews

Spectacular Lakefront Retreat on the Saluda

NicolasRating, 5 stars1 week ago
Sherri' spot was a delight! She handled everything from check in to check out, and made us feel welcome. The spot is quiet and close to the lake, and it was beautiful at night. Highly recommend this location.
Top guest favorite
Home in Anderson
4.97 out of 5 average rating, 138 reviews

Westwind Retreat Lake House

DaisyRating, 5 stars5 days ago
It was our second time staying there. It was great!

Private house rentals

Superhost
Home in Highlands
4.88 out of 5 average rating, 8 reviews

Wildcat's Lair

BrettRating, 5 stars10 months ago
Wildcat's Lair was a great rental for my family of six. The kids really loved the bunk beds and TVs in all of the rooms and we really were happy with the kitchen and the supplies for cooking/grilling. It was very comfortable for our family, very nicely decorated and beautifully landscaped. The location was convenient, easy to get to Highlands and Cashiers and the communication with any needs was very quick. I would stay here again for sure!
Superhost
Home in Walhalla
4.9 out of 5 average rating, 41 reviews

aunt helen's house

MyraRating, 5 stars1 month ago
I’m thrilled we found Aunt Helen’s place in Walhalla, SC. Home is perfect for a long weekend with friends and family. You feel at home when you walk in and it’s a very comfortable stay. We spent a lot of time on the porch swing enjoying the perfect weather. Did some walking around Walhalla shopping and eating in local restaurants. Great place to visit we’ll be back. We’ll be back the host are wonderful!!
Superhost
Home in Cashiers
5 out of 5 average rating, 7 reviews

5 minutes to town! Emerald Ferns Cottage

HeatherRating, 5 stars3 weeks ago
This was the cutest cabin with modern amenities tucked just outside downtown Cashiers! It was a very cloudy and wet weekend, but this cozy space was perfect for relaxing! The host was great and even gave a recommendation for a nearby hike to a waterfall that was beautiful! 10/10 would stay here again!
Guest favorite
Home in Fair Play
4.86 out of 5 average rating, 22 reviews

Bobber Bungalow *level lot*fire pit*kayak*canoe

JuliaRating, 5 stars1 week ago
This was honestly the most relaxing stay we’ve had in a very long time. Everything was very easily accessible. The stay is great and the water was absolutely perfect. We used the paddle board and the water mat and had a great time on the lake. Highly recommended just don’t forget bug spray!
Superhost
Home in Six Mile
4.85 out of 5 average rating, 238 reviews

House on Lake Keowee swim beach in cove w/ Dock

ShaunRating, 5 stars2 weeks ago
Place was cozy and wonderful for the stay. Cove was quiet and fun to swim in.
Guest favorite
Home in Hartwell
4.94 out of 5 average rating, 31 reviews

Lake Hartwell Hideaway

BrentRating, 5 stars1 month ago
Worry free, quiet, serene, relaxing spot.
Superhost
Home in Hartwell
4.77 out of 5 average rating, 13 reviews

Private Waterfront Oasis - Lake Hartwell

EddyRating, 5 stars5 months ago
wonderful place, the house gorgeous, perfect place to share with your family and friends, highly recommend.
Guest favorite
Home in Martin
4.88 out of 5 average rating, 101 reviews

Lake-House Escape w/Dock, Kayaks, Paddleboards

IvanRating, 5 stars2 weeks ago
Brian was a great host and his place was perfect for a quick Lake House getaway. we enjoyed the spaciousness of the house and especially loved the dock and lake. We enjoyed hanging out lakeside and taking the provided kayaks on the water. perfect for friends or families. I would recommend and definitely stay here again.

Quick stats about house rentals in Seneca

  • Total rentals

    30 properties

  • Nightly prices starting at

    $40 before taxes and fees

  • Total number of reviews

    1.5K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

Destinations to explore

  1. Airbnb
  2. United States
  3. South Carolina
  4. Oconee County
  5. Seneca
  6. House rentals