Vacation rentals in Seneca

4.99 out of 5 average rating, 106 reviews

A spacious outdoor dining area is visible through a large hinge window. The wooden table is surrounded by four folding chairs, with a scenic view of the lake and trees in the background. Sunlight filters through, enhancing the seamless indoor-outdoor connection.

Cottage in Seneca

Destination Keowee

A rustic industrial style Lake Keowee lakefront escape that places you right on a panoramic point in a private cove. Welcome the outdoors in with the 6ft kitchen hinge bar window to the upper deck or enjoy the 6-seat hot tub on lower deck. Deep water dock tie off space is available. Guests enjoy the use of 2 standup paddle boards, and lakeside fire pit (guest provide firewood). Great cove sunsets! 15 minutes to Clemson and 1 min Lighthouse Restaurant. Please read all details prior to booking!

4.99 out of 5 average rating, 162 reviews

The cottage exterior displays warm wood siding with large windows allowing natural light. A welcoming front porch features two chairs and a small plant, while a grill stands nearby. Surrounding landscaping creates a serene atmosphere in a private setting.

Cottage in Central

The Wildflower

Enjoy a relaxing experience at this centrally-located spot, away from the hustle and bustle but only 6 min from Clemson (10 min from Clemson University), nestled in the country in a peaceful, safe neighborhood with lots of privacy surrounding. The cottage has a front porch with 2 chairs, a 2 person hammock, grill, and a fire pit (wood is provided) with three lawn chairs. There’s a queen bed and also a CordaRoy beanbag (*bed #2) that opens up to a soft bed that sleeps 1 adult or two children.

4.95 out of 5 average rating, 169 reviews

A cozy bedroom is highlighted by a spacious bed with a patterned blanket. Two bedside lamps provide soft illumination on either side. A wooden dresser is positioned against the wall, and a window allows natural light to fill the space, complemented by cream-colored walls.

Apartment in Seneca

Clemson Mom Apartment

Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.

4.98 out of 5 average rating, 188 reviews

A charming cabin is nestled among tall trees, accessed by a stone path. Warm string lights adorn the porch area, creating a welcoming glow. Fallen leaves blanket the ground, complementing the natural surroundings and inviting a sense of tranquility.

Cabin in Pickens

The Romantic Greystone Cottage

Follow the enchanting stone path to a private getaway where romance and connection await. Enjoy the ambiance of the starlit sky while cuddled up on the hammock or around the fire. Cozy up on the king-size bed and relish every moment of your stay. Indulge in a bottle of wine and relax by soaking in the luxurious claw-foot tub. Wake up to the tranquil sounds of the forest, savoring the morning with coffee on the porch. Escape the everyday and embrace what matters most at The Greystone Cottage.

Superhost

A wooden dock extends across the calm water, leading toward a lush green shoreline. The surface of the lake reflects the blue sky, while gentle ripples are visible. Surrounding trees contribute to a serene natural setting.

4.85 out of 5 average rating, 223 reviews

Cozy Lake House 5 miles from Clemson w Dock

Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

A charming home is presented in a serene neighborhood setting, featuring a well-maintained lawn and flowering shrubs. The exterior showcases a light-colored façade with a welcoming front porch and a spacious driveway leading to a two-car garage.

4.99 out of 5 average rating, 210 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

4.95 out of 5 average rating, 259 reviews

A charming exterior view of the Tiny Treehouse features a bright red roof and wooden siding with a sunflower design. A picnic table sits on the lawn, surrounded by green grass and trees. A lounging area with rocking chairs is nearby, providing a welcoming outdoor space.

Tiny home in West Union

Holliday's Inn Tiny Tree-house

Tiny Treehouse is a ‘container’ house set in a private wooded locale at the foothills of the mountains. Find yourself hiking at Oconee State park or Caesar's Head mountain along with a multitude of waterfalls within our county. 5 minutes from downtown historic Walhalla, 10 minutes to city of Seneca, and 20 minutes from Clemson University where tailgaters unite before the big football game! Explore the artistic venues and cultural scenes of Greenville just an hour away!

4.97 out of 5 average rating, 170 reviews

A modern cottage features a spacious covered porch with string lights, surrounded by a lush green lawn. Large glass doors invite natural light into the interior, while tall trees provide shade in the background against a colorful sunset sky.

Cottage in Anderson

Lakefront dock *hot tub* Anderson Clemson King bed

Relax & enjoy the beautiful views of lake Hartwell from the front porch daybed swing, hot tub, or private dock. Sleep in a king size bed wrapped in cool cotton linens, a towel warmer, soaking tub with TV, & a breville espresso maker. Located w/i 10 minutes of many restaurants. Less than 20 min. to downtown Anderson Pendleton or Clemson. This prime location on lake Hartwell is a 10 minute boat ride to Portman Shoals Marina, the Galley restaurant, & Green Pond Landing.

4.96 out of 5 average rating, 112 reviews

Two individuals sit on a dock overlooking the calm lake, draped in colorful beach towels. Adirondack chairs provide comfortable seating, positioned to enjoy the serene water views and surrounding greenery. A potted plant adds a touch of color to the peaceful scene.

Guest suite in Seneca

Hartwell Escape 6 mi to Clemson Beautiful views

We recently purchased this gorgeous home on Lake Hartwell, in a secluded cul-de-sac in a quiet neighborhood (6 miles to Clemson..ALL BACKROADS) You will have the entire bottom floor with separate entrance . Enjoy beautiful lake views on the covered porch or from our dock. A Private Neighborhood Boat ramp is 25 feet from our home. Bring your boat, use our dock, space for multiple trailers. Driveway parking. Dogs Welcome! ($25 pet fee/entire stay)

4.97 out of 5 average rating, 564 reviews

The exterior of a modern tiny house is depicted, featuring a dark blue façade and large windows allowing natural light to fill the interior. The covered porch is accessible from the gravel pathway, and greenery surrounds the property, enhancing the wooded setting.

Cottage in Westminster

Tiny house

BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.

4.96 out of 5 average rating, 211 reviews

A charming tiny house is set amidst wooded surroundings, featuring a welcoming entrance with a white door and a light-colored roof. Two white chairs and a small table are positioned on a wooden porch, complemented by a grill nearby. Lush greenery enhances the tranquil setting.

Tiny home in Seneca

Windmill Cottage

You’ll treasure your time at this cute little cottage. It is 295 sq feet and was built in 2023 at the edge of the woods on our property. It has a full kitchen, bedroom with a queen bed, bathroom and living room. It is perfect for one or two people, for either a quiet get-away in the country or for someone who is in town for work and is looking for a more extended stay. We offer discounts for weekly/monthly stays!

4.9 out of 5 average rating, 128 reviews

A travel trailer is parked on a gravel area surrounded by trees. The exterior features light colors with dark accents, while a picnic table is positioned nearby on a partially rocky ground.

Guesthouse in Six Mile

Camper at Hickory Lodge and Guesthouse

Simple, relaxed atmosphere on a nicely wooded property less than 10 minutes from public launch and Sunset Marina on Lake Keowee. Boat parking is available. Only 19 minutes from Memorial Stadium, 15 minutes from Seneca, Pickens, Clemson. LESS THAN A MILE FROM DUKE OCONEE PLANT Need another bedroom? Please see our other listings

Vacation rentals for every style

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Cabins

Kick off your hiking boots at these rustic lodgings

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Stylish accommodations and amenities

Popular amenities for Seneca vacation rentals

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Air conditioning

Other great vacation rentals in Seneca

A bright and spacious kitchen features a central island with a granite countertop, surrounded by blue upholstered chairs. A dining table with wicker chairs is located nearby, and natural light fills the room through sliding glass doors leading to the outdoor area.

4.96 out of 5 average rating, 99 reviews

Cozy Clemson Hideaway • 5 min to Campus • Wi-Fi

5 out of 5 average rating, 14 reviews

A serene lakeside view is presented, featuring a gently sloping lawn leading towards the water. Trees provide natural shade, while a private dock and boat lift are visible near the shoreline. A pathway guides toward the dock area, creating a seamless transition from the house to the lake.

Guest suite in Seneca

Southern Scandinavian Lakehouse•13 mi to Clemson

A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.

4.92 out of 5 average rating, 38 reviews

Lakefront Mid-Century Dream Home / 3 mi to Clemson

5 out of 5 average rating, 16 reviews

A tiny house cabin is viewed from the front, showcasing its blue exterior and wooden porch. Four outdoor chairs are positioned on a gravel area, with steps leading up to the entrance. Large windows provide natural light, framed by a canopy of trees.

Tiny home in Seneca

Cozy Clemson Tiny House Cabin

Shipping container in Walhalla

A vintage clawfoot tub is positioned next to large windows, offering sweeping views of the surrounding mountains and forest. Natural light filters in, illuminating the space adorned with a potted plant and a small decorative vase. Glass shower fixtures are mounted nearby.

4.97 out of 5 average rating, 30 reviews

Valhalla Sky Suite at Hisaw Gap Romantic Retreat

4.98 out of 5 average rating, 91 reviews

A vintage camper is positioned under a canopy, offering protection from the elements. An outdoor seating area features a table with a small grill nearby. A stack of firewood is neatly organized beside a fire pit, surrounded by comfortable chairs on a textured surface.

Camper/RV in West Union

Nordic Highlands Retreat, 30' Vintage Camper

An open living and dining area is filled with natural light, highlighted by large windows. A television sits on a media console, while a cozy couch invites relaxation. A dining table for six is visible in the background, complemented by bright seating arrangements.

5 out of 5 average rating, 26 reviews

Tween 2 Cats the perfect spot