Apartment vacation rentals in Rochester

Penthouse Suite—Steps from Mayo Clinic Hospital

This luxury suite is a private wing on the 3rd floor of a newly renovated 3-story mansion. Conveniently located in one of the trendiest neighborhoods in Rochester. Steps from the Mayo Clinic St. Mary's hospital, Starbucks & Caribou coffee, restaurants, grocery stores, nightlife & downtown. FEATURES High speed internet 75” HD LED TV Workspace High-end interior King size beds Washer/dryer Fully stocked kitchen Free garage parking Keyless entry Super convenient for short-term or long-term stays.

Woodland Retreat, Full private walkout lower level

Peaceful retreat down gravel driveway 15 min from Mayo Clinic. Enjoy your own apartment with private backyard walkout entrance to the lower level of our home. You will have a bedroom, living area, kitchenette with mini fridge, microwave and toaster oven (no conventional stove/oven), bathroom w/ tub & shower, pingpong table, laundry, and patio with fire ring. You may hear piano music weekday afternoons, since I give lessons (usually 3-6 pm; a bit earlier in summer) NEW HEATED FLOORS w/thermostat

Fresh space near Mayo Clinic and downtown

Minutes away from downtown shops, restaurants, and Mayo Clinic, this main-level apartment is newly-renovated, cheerful, and ready for your arrival. The open living/dining area feels spacious and bright, with two picture windows letting in lots of natural light. Enjoy two private bedrooms, each with a queen-sized bed. Fully-equipped kitchen makes for efficient cooking and baking. Bus stop less than a block away. Trails nearby. From May-Oct, visit the local Farmer's Market at Graham Park.

Relaxing, main floor apartment in 4plex, #2.

This is a quiet main floor apartment (491 sq. ft.) in a 4-plex located 1 mile from Mayo. It has a all of the cooking necessities needed to make your own meals. There is a full size bed in the bedroom. This unit is in an older house with radiator heat and a big front porch. The floors are squeaky in a few places. Since it is a 4plex you will hear some sounds from other guests but it is generally quiet. There is parking behind the house and a washer and dryer in the basement available to guests.

Lux 1 BR I 1 Block to Mayo Skyway I Parking I Pets

Welcome to your luxury refined home base in the heart of downtown Rochester. Located at The Maven on Broadway, this upscale one-bedroom apartment offers the perfect blend of comfort, convenience, and elevated living—just a short walk to the skyway connecting you in minutes to the Mayo Clinic System. Whether you’re here for medical care, professional work, or supporting a loved one, this thoughtfully designed space provides a calm, stylish space with all the amenities needed during your stay.

Spring Special!| Rochester South East Airbnb

We welcome you to our cozy home base Airbnb unit in the heart of Rochester, Minnesota where comfort meets unbeatable charm and convenience! What can you expect? Very clean and modified unit that meets all your expectations, perfectly located less than a mile from the Mayo Clinic! This amazing place is just a quick 5-min drive (or an easy 20-minute walk) to the Mayo Clinic, making it an ideal stay for medical travelers, medical professionals, or a day out and about near the HEART of Rochester!

Charming 2 Bedroom Close to Mayo Summer Discount!

Peaceful and centrally located cottage. This home is a beautifully furnished main-level triplex just 5 minutes from Mayo Clinic. Bus stop on property and multiple restaurants 3 minutes away. This 2-bedroom, 1-bath unit has everything you might need to recover from a surgery, to feel at home while seeking treatment or to enjoy beautiful Rochester. The house is child friendly with a nice selection of toys and books to keep the little ones occupied. Pets welcome at a charge of $50/pet/month.

Restful sanctuary close to Mayo Clinic

This cozy space has private, self-entrance with off-street parking at no cost...a mere 2.5 miles or 10 minute drive to the Mayo Clinic downtown. Located in a quiet neighborhood in northwest Rochester. Easy access to highways, grocery store, coffee shop, Target, restaurants and biking/walking trail. Completely furnished with linens, hair-dryer, Netflix and Hulu, Smart TV and Wi-fi....and a Keurig Coffee maker with enough coffee pods to get you started. Truly, a home away from home!

SALE: Remodeled retreat near Mayo Clinic

• Enhanced cleaning protocols due to COVID • Fully renovated apartment in summer 2018 • Brand new kitchen in March 2026 • 650 square feet • Upstairs apartment in quiet 4plex • Free off-street parking • 5 blocks north of Mayo Clinic • Walk-in tiled shower • Queen bed • Oversized power recline La-Z-Boy chair • Reclining leather loveseat • 43" Smart TV with DirecTV/cable • High-speed WiFI — 300 MBPS • Shared laundry in the basement • Huge windows for tons of natural light

Peaceful Riverside 2Bed/2Bath w/balcony near Mayo

Welcome to The Lofts at Mayo Park, a river-view apartment nestled along the scenic Zumbro River in Rochester, MN. Offering the perfect blend of modern elegance and tranquility, this upscale stay is just minutes from downtown and the Mayo Clinic yet tucked away in a peaceful, private setting. Tenants may be seen lounging on the front porch, listening to drifting notes from the piano, and visiting the surrounding parks, riverside trails, and community facilities!

St. Mary's Classic

This special place is close to everything, making it easy to plan your visit. Relax in this well-appointed and carefully curated one-bedroom apartment located one block from Mayo Clinic's St. Mary's Hospital. It is located on the third floor (no elevator) of the classic, early 20th century brick apartment building, Leland. The owner/host is a life-long Rochester resident. Quality, cleanliness and comfort are our motivation.

Beautiful Duplex home 5 minute walk to Mayo Clinic

This home is located in the heart of the historic Rochester, MN. Just a stones throw from the Mayo Clinic. This downtown area is packed with shops and eating establishments, all interconnected via the walking subway system, for those cold winter days. When the weather warms, beautiful parks and paths abound in an endless display of green natural space. I hope your travels are safe and look forward to meeting you.