Skip to content

Cape Girardeau vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Private room in Cape Girardeau
230L - Civil War era home, by downtown
Private room with shared bath upstairs. This room is built for long term stay with large long term (7+ days) discounts, a mini fridge and full dresser. This Civil War era home was built in 1870 by a retired Union General. It is located on the highest point in the area and overlooks downtown Cape Girardeau. Your room is on the second floor with a shared second floor bathroom. There is a single cat living on the property. She is very friendly and will try to sleep with you if your door is open.
$57 per night
SUPERHOST
Private room in Cape Girardeau
Private entry walk-out basement to yourself!
Peaceful and quiet. 3 minutes to SEMO. 6 minutes to the Mississippi River. 13 minutes to the Cape Girardeau airport. Just minutes to drive to downtown Cape for awesome historical restaurants and more. New Farmhouse style with Private Entry Walkout Basement with self check-in, free WIFI, Netflix, HBO Max and free on-street parking. Beautiful and peaceful home with backyard wildlife: birds, bunnies, deer and squirrels and a waterfall for a serene environment. Home is powered by solar energy.
$59 per night
SUPERHOST
Home in Cape Girardeau
House Of Clubs- 2 Bed 1.5 Bath
The PERFECT hideway. The House of Clubs offers a quiet setting with a creek that wraps around the enitre property. Two bedrooms, each include a queen size bed. One Full bathroom. Full Laundry room that also offers a private cammode. The stylish living room offers a unique style that higlights Cape Girardeaus rich history. Enjoy your morning coffee in the four seasons room with breathtaking views of this hidden gem . Less than 5 minutes to downtown. Only 2 minutes to Cape Country Club.
$110 per night
SUPERHOST

Stay near Cape Girardeau's top sights

Photo of Capaha Park
Capaha Park4 locals recommend
Photo of Katy O'Ferrell's Publick House
Katy O'Ferrell's Publick House9 locals recommend
Photo of Dogwood Social House
Dogwood Social House3 locals recommend
Photo of Port Cape
Port Cape13 locals recommend
Photo of Mary Jane bourbon + smokehouse
Mary Jane bourbon + smokehouse7 locals recommend
Photo of Pilot House Restaurant & Catering
Pilot House Restaurant & Catering3 locals recommend

Weekly rentals in Cape Girardeau

Home in Cape Girardeau
Herman’s Cozy Corner
$61 per night
SUPERHOST
Home in Cape Girardeau
❤ of Cape Girardeau *5min→Hospitals & SEMO
$75 per night
SUPERHOST
Rental unit in Cape Girardeau
Williams Parkview Flat (lower)
$81 per night
Private room in Cape Girardeau
Sunshine Suite
$37 per night
Home in Cape Girardeau
Vintage & Charming 3-Bedroom Home
$82 per night
SUPERHOST
Loft in Cape Girardeau
Loft #4 Downtown Cape Girardeau , Music & Food
$160 per night
SUPERHOST
Guest suite in Cape Girardeau
Charming Master Suite w/ Private Entrance
$57 per night
SUPERHOST
Guest suite in Cape Girardeau
Cape Comfy! Close to SEMO! Private! CLEAN! 5 Star!
$61 per night
SUPERHOST
Guesthouse in Cape Girardeau
Downtown Guesthouse- Romantic Getaway
$102 per night
SUPERHOST
Home in Cape Girardeau
Cozy Cottage
$129 per night
SUPERHOST
Home in Cape Girardeau
Stay In DOWNTOWN Cape!
$113 per night
Guest suite in Cape Girardeau
MAINSTAY CAPE [downtown]
$76 per night
SUPERHOST