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Vacation rentals in Lake City

Book unique homes, vacation rentals, and more on Airbnb

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Popular amenities for Lake City vacation rentals

Lake side house rentals in Lake City

Superhost
Home in Fort McCoy
4.88 out of 5 average rating, 151 reviews

Relaxing Lakefront Getaway on Private Lake in FL

MarfaRating, 5 stars2 months ago
We always have a great time at the lake house! We have made beautiful memories and will continue to do so. Thank you Jennifer for allowing us to make all these great memories at your lake house these last several years! We always feel right at home. The lake is amazing, my husband loves that he is able to put the boat in the water right from the yard. He and the kids love the bass they catch out there! We love kayaking around the lake too! The water is always so clear. Wonderful and friendly neighbors. The house is also perfect for us. No matter the weather we always have an amazing time!
Top guest favorite
Home in Lake Park
5 out of 5 average rating, 197 reviews

Lakefront guesthouse by I-75 and the FL/GA line

MorganRating, 5 stars1 week ago
We really enjoyed our 2 night stay here. The inside was very clean and comfortable and the backyard was great for our 2 year old. He loved playing in the sand and we had a great view of the lake. Was also a short drive to several restaurants, groceries, etc. Hosts provided plenty of extras and all the info we needed during our stay.
Top guest favorite
Home in Lake Park
4.99 out of 5 average rating, 157 reviews

Lakefront home. sleeps 4- 1 bedroom 1 bath

MichaelRating, 5 stars5 days ago
The lakefront home was amazing. It was exactly what we were looking for with our two little Yorkies. The backyard was completely fenced in, the landscaping was so beautiful, the home was fully stocked in the kitchen and bathroom, and the lake was so peaceful. We stayed for two nights, next time we will definitely stay longer. Thank you so much William!
Top guest favorite
Home in Melrose
4.97 out of 5 average rating, 100 reviews

Sante Fe Lakehouse with Canal for your Boat

DanielRating, 5 stars1 month ago
Beautiful home on a perfect lake - I rented both houses for a shared bachelor week, and every was amazing. Our hosts were friendly and helpful, including setting us up with 7 kayaks. The houses were both better than they looked in the pictures, with large modern kitchens and nice furniture. The beds were comfortable and the bathrooms were nice. Lastly, the docks are great, and there are lots of birds and fish around. Sunsets and sunrises were beautiful, and the property was largely shaded so it was pretty cool throughout the day. There was a bunch of parking.
Top guest favorite
Home in Lake Park
4.98 out of 5 average rating, 165 reviews

Enjoy beautiful sunsets at "Turtle Cove"!

Taylor RaeRating, 5 stars1 week ago
Absolutely serene. The perfect place to get away and relax!!
Top guest favorite
Home in Live Oak
4.97 out of 5 average rating, 189 reviews

The Blue House

JohnnyRating, 5 stars2 weeks ago
We stayed here on our way to South Florida and loved it! My wife fell in love with the white duck that was very friendly. She actually is making a 12x10 photo of him/her and putting the sweet little fella on our wall. A nice reminder of a very quiet and peaceful place along our travels. We will definitely stay here again on our next trip when passing through!!
Guest favorite
Home in Melrose
4.91 out of 5 average rating, 106 reviews

Three Bedroom House on Private Scenic Lake Mable

CarrieRating, 5 stars1 week ago
Great place. Nice area. We didn’t spend much time at the house due to us visiting family but it was great for what we needed!
Guest favorite
Home in Keystone Heights
4.9 out of 5 average rating, 156 reviews

Lake house - Kayaks and Fishing Poles

TamikaRating, 5 stars1 week ago
We had such a wonderful stay at this beautiful lakefront Airbnb! The house itself is absolutely lovely—tastefully decorated, cozy, and incredibly welcoming. It immediately felt like a home away from home, which made our time in Florida all the more special. The hosts were fantastic—very responsive, kind, and genuinely friendly. They made sure everything went smoothly from start to finish, and their attention to detail really showed. This rental was the perfect spot for us while we wrapped up a few final things before our move from Ohio to Florida. Peaceful, comfortable, and well cared for—we couldn’t have asked for a better place to stay. Highly recommend!

House rentals in Lake City

Superhost
Home in Duckpond
4.94 out of 5 average rating, 178 reviews

Charming Studio Apt Near Downtown

ElizabethRating, 5 stars6 months ago
We came down for the Fla LSU football game. We had a great time, and everything was conveniently located from the home. The price was a little higher than we would of liked to of paid for but we know on football weekends any place is going to be a little pricier. We had a wonderful time and Glani's place was what we needed. Simple no fuss. Just a great place to rest our heads after a long day of being at the game. Thank you for your hospitality.
Top guest favorite
Home in Live Oak
4.97 out of 5 average rating, 109 reviews

Your home when ur gone from urs

CeciliaRating, 5 stars4 weeks ago
Traveling through to Atlanta we stayed overnight at this charming home. The place was clean and comfortable and in a quaint and quiet neighborhood. Anita is a considerate host and made sure we had everything we needed for our short visit, even confirming our arrival time so the porch lights would already be on for us since we checked in late. Would recommend and gladly book again.
Guest favorite
Home in Gainesville
4.8 out of 5 average rating, 191 reviews

Very Spacious house 6 miles from U of FL VA/Shands

JamesRating, 5 stars2 weeks ago
Great place for a family group attending a wedding at very close by Kanapaha Botanical Gardens! Spacious and met our needs. Not only is it close to the wedding venue, it was close to everything we needed. Seemed like being out in the country but Publix, Sam's Club, Walmart, Target - anything needed was just minutes away. Our bed was incredibly comfortable. Very much as advertised. Hostess was kind and responsive and would highly recommend.
Superhost
Home in Jacksonville
5 out of 5 average rating, 8 reviews

3bdrms 4bds 2 bthrm Modern home

NikaaRating, 5 stars1 week ago
My stay at April’s property was thoroughly enjoyable. The space was exceptionally clean, the beds were remarkably comfortable, and the home was well-equipped with everything I needed to cook for my family. Thank you for providing such a welcoming and restful home away from home.
Guest favorite
Home in Gainesville
4.79 out of 5 average rating, 138 reviews

Beautiful Family home located downtown & VA, UF🏈

KristiRating, 5 stars1 day ago
We stayed one night for a concert and this was an ideal location for a short walk to Heartwood Sound Stage and local nightlife! The place is exactly as described and everyone commented in the morning on how comfortable the beds and linens were! We will certainly stay again for our next trip to the area! There was a fan in the closet that came in handy for white noise to sleep and cool off after our walking expeditions.
Guest favorite
Home in Perry
4.83 out of 5 average rating, 24 reviews

Cozy & peaceful house in Perry Florida

KatriceRating, 5 stars3 months ago
Great home and hosts! Looked just like the pictures! We would stay here again!
Superhost
Home in Alachua
4.83 out of 5 average rating, 225 reviews

Gated Golf Getaway close to Springs and UF

AshleyRating, 5 stars1 month ago
Very peaceful neighborhood. Room to cook, relax, enjoy the backyard and more. We had six guests stay and had plenty of room without feeling cramped! Would book again.
Superhost
Home in Gainesville
4.79 out of 5 average rating, 28 reviews

The Gainesville Rock House

CodyRating, 5 stars1 month ago
The house is conveniently located to downtown Gainesville and perfect for a small group! The house is clean, plenty of bath towels. We enjoyed our stay!

Lake City fishing vacation rentals

Guest favorite
Cabin in Interlachen
4.87 out of 5 average rating, 101 reviews

Cabin • Cabana • Bunkhouse • Dock • Nr Gainesville

SarahRating, 5 stars5 months ago
We really enjoyed our stay- the kids and teens loved the canoes and kayaks as well as the ping pong table. The dock was a great place to relax! The buildings have some wear as described by the host but we were impressed with the cleanliness and we didn’t see even one bug inside, which was greatly appreciated. We would stay again!
Guest favorite
Camper/RV in Hawthorne
4.95 out of 5 average rating, 106 reviews

Private Lake Camper with dock/kayaks and patio

ChristyRating, 5 stars1 week ago
Consistently great! Great people, great location!
Guest favorite
Apartment in Melrose
4.87 out of 5 average rating, 199 reviews

The Orchid of Lake Santa Fe

JaneRating, 5 stars2 weeks ago
Lesley was very accommodating, friendly and helpful if a need presented itself... made extra room for our Boat trailer and two cars and her husband Steve even found a Fuse for our boast when the Bilge Pump went out. The couple made an effort to make certain you enjoyed your stay. We look forward to coming back to say at the 2 bedroom cottage on the water in early Fall. Thanks, Jane
Top guest favorite
Cottage in Keystone Heights
4.98 out of 5 average rating, 59 reviews

Crystal Lake Retreat

Alexandra StricklandRating, 5 stars1 month ago
Dawn is amazing! This was our second time staying here, and we have already booked it again. Her family also took the time to take us for a boat ride, and took my kids tubing, genuinely kind people. The lake could not be more beautiful. The house has a wonderful beach(this is not very common in Keystone Lakes), and my girls spent hours fishing and swimming. Highly recommend!
Top guest favorite
Cabin in Hawthorne
4.96 out of 5 average rating, 154 reviews

Charming Lakefront Log Home

KristinRating, 5 stars3 weeks ago
We enjoyed our stay for my daughter's 21st birthday, with family. Our stay was absolutely perfect. I broke my patella 2 weeks before our trip. Although I couldn't join in the water activities, I was extremely relaxed on that back porch under the beautiful oaks and feeling the gentle breezes. I would fully recommend this for people who want a nice, peaceful, vacation with a beautiful view. Thank you! And the log house is so comfortable, too.
Guest favorite
Cottage in Keystone Heights
4.88 out of 5 average rating, 144 reviews

Charming lake front cottage

KristiRating, 5 stars1 day ago
Cute little place for a lay over to break up the drive.
Guest favorite
Cottage in Hawthorne
4.93 out of 5 average rating, 73 reviews

Cheerful 2 bedroom Cottage on serene Lake McMeekin

Jonathan And RebeccaRating, 5 stars2 months ago
We had a wonderful time enjoying the cottage and its lakefront and peaceful surroundings. The house was very clean and had all we would need. While there was a new Wi-Fi and starlink with good internet, It really was a good time to disconnect and enjoy the wildlife and sunrise on the lake with nearby state parks, bike and hiking trails. So much to do. We hope to come back. Thanks for hosting us!
Top guest favorite
Cottage in Lake Park
4.98 out of 5 average rating, 169 reviews

Perfect Cottage on the Lake

KyleRating, 5 stars1 month ago
Beautiful home, Beautiful lake, great swimming spot to stay cool and we caught so much fish!! We will be planning for another stay! ☺️

Quick stats about vacation rentals in Lake City

  • Total rentals

    40 properties

  • Nightly prices starting at

    $40 before taxes and fees

  • Total number of reviews

    1.2K reviews

  • Family-friendly rentals

    30 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

Your guide to Lake City

All About Lake City

Lake City is a small town regarded as the Gateway to Florida, thanks to its northern location midway between Jacksonville and Tallahassee. Although its name might imply there’s only one lake in the community, you’ll find several bodies of water fed by clear freshwater springs here, making the town a popular spot for all sorts of water and lakeside activities. Anglers come to try their luck in the local pools and streams, which are home to white bass, sunfish, and pickerel. Kayakers launch into the wetlands near Alligator Park or picnic on the shores. The town also makes a great starting point for exploring Columbia County and Northern Florida, where you’ll discover state and local parks threaded with hiking and biking trails and abundant freshwater sources like Ichetucknee Springs, famous for its warm-water tubing.

Downtown Lake City centers on Marion Street, featuring shops, eateries, and several renovated historic buildings, including a famous hotel that has hosted numerous musicians and other celebrities. The town’s sense of community revolves around a creative atmosphere, with live music, art exhibitions, and a growing brewery scene.


The best time to stay in a vacation rental in Lake City

Like the rest of Florida, Lake City has a humid, subtropical climate. It can be hot in summer, with strong sunshine. Sun-worshippers may choose to visit between June and September, while spring temperatures are comfortably warm. If you plan to visit during this time of year, you may want to consider reserving your Lake City vacation rental for Memorial Weekend. Each May, the Florida Folk Festival takes place in White Springs, just over 10 miles from Lake City, and features live music, traditional craft demonstrations, and a children’s music and play area.

Visiting in mid-October will allow you to take in the Alligator Warrior Festival, a celebration of the Seminole commander, Alligator Warrior, who lived in the area, with music, living history displays and demonstrations, and food and crafts.


Top things to do in Lake City

Gateway Art Gallery

Gateway Art Gallery is a nonprofit community arts organization and a creative hub featuring works by local artists inspired by the Lake City region. The gallery showcases paintings, photography, carvings, and stained glass. You can also learn new artistic techniques at one of the regular workshops.

Ichetucknee Springs

Less than 20 miles from Lake City, Ichetucknee Springs has crystal-clear water ripe for exploring. You can try canoeing, kayaking, paddleboarding, or even tubing here. Fed by nine springs, the river is as clean as the turquoise waters would suggest, and the current will guide you past woodlands of oaks, pines, and maples. Plenty of wildlife species call the springs home, including wading birds, turtles, otters, and deer.

Columbia County Historical Museum

Located in an original 1870s house, Columbia County Historical Museum features a quirky collection of artifacts and memorabilia. Each room represents a different era in local history, with relics, heirlooms, and exhibitions telling stories of times past. You can book a guided visit, or take part in historical scavenger hunts, storytelling events, and even craft workshops.

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Lake City?

    Yes! Work meets play with ease at over 20 vacation rentals in Lake City featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Lake City?

    Four-legged friends are welcome in Lake City. Choose from more than 10 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Lake City?

    Experience the best of Lake City with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there family-friendly vacation rentals in Lake City?

    Lake City has more than 30 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

Destinations to explore

  1. Airbnb
  2. United States
  3. Florida
  4. Columbia County
  5. Lake City