
House vacation rentals in Isle of Palms
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Top-rated house rentals in Isle of Palms
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Isle of Palms house rentals
House rentals with a pool

54 Grand Pavilion Wild Dunes, IOP, SC Beach Views

Spacious Island Home with Private Pool & Spa!

Beautiful 2BD/2BA Seabrook Island Villa

Hammock Haus -cozy firetable- 10 min to downtown

SALTWATER OASIS AT THE BEACH, Isle of Palms, SC

IoP - Luxury 5BR w/ Beach Views and Beach Access

Exclusive Home & Yard, Beach 1 Block, Heated Pool*

Renovated House w/ Pool, Sauna,Gym,Outdoor shower!
Weekly house rentals

Mt Pleasant Cottage-Downtown, Shem Creek & Beaches

Easy Beach Access across street! IOP 2BR Condo!

Updated home private pool & 3 mi to beach!!

Santorini Cottage

Casa Zoë | Historic Garden Carriage House CHS

Panoramic Marsh View, Private retreat - 33 Marsh

Sandwedge 7 by Wild Dunes, Luxury Home

Edisto Dream - Walk to Beach, Bikes, Kayaks, Golf!
Private house rentals

Architecture* La Cabaña * Beach 8 min * 2 Bdrm

Wild Dunes Home Steps from Beach

Welcome to Ohana House!

Little Bit O' Heaven

Lee's Beach House

4BR home near beach with deck, outdoor shower, W/D

Stunning Waterfront

Walk to Beach 3BR Dog Friendly | Deck | W/D
Quick stats about house rentals in Isle of Palms
Total rentals
760 properties
Nightly prices starting at
$30 before taxes and fees
Total number of reviews
11K reviews
Family-friendly rentals
740 properties are a good fit for families
Pet-friendly rentals
230 properties allow pets
Rentals with a pool
560 properties have a pool
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- Rentals with a hot tub Isle of Palms
- Rentals with an EV charger Isle of Palms
- Rentals with outdoor seating Isle of Palms
- Luxury rentals Isle of Palms
- Rentals with pools Isle of Palms
- Family-friendly rentals Isle of Palms
- Pet-friendly rentals Isle of Palms
- Rentals with a fire pit Isle of Palms
- Rentals with a kayak Isle of Palms
- Beach house rentals Isle of Palms
- Apartment rentals Isle of Palms
- Rentals with a washer and dryer Isle of Palms
- Condo rentals Isle of Palms
- Rentals with a fireplace Isle of Palms
- Villa rentals Isle of Palms
- Rentals with a patio Isle of Palms
- Fitness-friendly rentals Isle of Palms
- Waterfront rentals Isle of Palms
- Rentals with beach access Isle of Palms
- Beachfront rentals Isle of Palms
- House rentals Charleston County
- House rentals South Carolina
- House rentals United States
- Park Circle
- Hunting Island State Park Beach
- Sullivan's Island Beach
- Bulls Island
- Middleton Place
- The Golf Club at Wescott Plantation
- James Island County Park
- Waterfront Park
- Shem Creek Park
- Harbor Island Beach
- Hampton Park
- The Charleston Museum
- Angel Oak Tree
- Driftwood Beach
- Isle of Palms Beach
- Morris Island Lighthouse
- Seabrook Island Beach
- The Beach Club
- Charleston Aqua Park
- White Point Garden
- Seabrook Beach
- Gibbes Museum of Art
- Whirlin' Waters Adventure Waterpark
- Splash Zone Waterpark At James Island County Park
- Family travel hub Tips and inspiration
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- Kid-friendly state parks Check out these family-friendly hikes