Vacation rentals with lake access in Santee

Find and book unique lake access rentals on Airbnb

Top-rated lake access rentals in Santee

Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A charming yellow studio is nestled among trees, accessible via stairs on the left. The home features several windows that brighten the exterior. A well-maintained garden with a manicured lawn surrounds the property, creating a welcoming first impression.
Guesthouse in Columbia
5 out of 5 average rating, 159 reviews

Amazing Studio Guesthouse in COLA suburb.

Just 10 mins off of route 77, Fort Jackson & Downtown COLA only 20-30 min drive. Studio’s located in a beautiful family-friendly, suburban Lake community in Columbia SC with grocery stores & gas stations within minutes. Enjoy a night in equipped with movie screen & projector, then finish the night by melting your worries away into an incredibly soothing king size memory foam bed. Let our all-in-one washer/dryer do the work for you and wake up to a finished cycle and sounds of SC’s native birds.

Top guest favorite
A historic cottage is set amid tall trees, with a light-colored exterior and a sloped roof. Steps lead up to a welcoming porch, surrounded by green grass and shrubs, offering a sense of serenity within the private yard.
Cottage in Columbia
4.97 out of 5 average rating, 572 reviews

The Historic Selwood Cottage @theselwoodcottage

Private, historic cottage with screened in porch. Sleeps 5 in 2 bedrooms with full, furnished kitchen. PET FRIENDLY. Property owners on shared property available to help with any needs. Enjoy over an acre of private land in the heart of the city. Lake Murray within walking distance as well as Harbison shopping area 5 miles away and downtown Columbia 15 miles away. *NO PARTIES TOLERATED NO SMOKING INSIDE OR OUTSIDE* If your dates are unavailable ask about our other Airbnb “Otto the Airstream.”

Top guest favorite
A serene view from a screened porch is shown, featuring two wooden rockers facing the tranquil lake. Green grass and trees surround a private dock visible in the distance, creating a peaceful outdoor setting.
Cottage in Manning
4.98 out of 5 average rating, 125 reviews

Archie's Lake Daze Cottage No pets

Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Top guest favorite
The exterior of the duplex is shown, featuring a well-maintained lawn with fallen leaves and a pathway leading to the entrance. Large windows are visible, allowing natural light, while an American flag adorns the front. A mailbox marked '116' is positioned at the driveway.
Guest suite in Columbia
4.93 out of 5 average rating, 371 reviews

Comfy & Private Left Half of a Duplex

Lexington Permit #2500623 Listing is a private, cozy half duplex. Private entrance, parking in a quiet neighborhood. Bathroom has a new large shower, towels, shampoo/conditioner, lotion, soap, vanity. Bedroom has queen bed, walk-in closet, TV. Kitchenette has sofa lounger, microwave, mini fridge, TV, coffee makers (single cup/round pod or ground type), dishes, glasses, silverware. *1 mile from Saluda Shoals Park/ Lake Murray. *4 miles from Columbian Mall - tons of shopping and restaurants.

Guest favorite
A charming log home is set on a grassy lot, surrounded by trees. The façade showcases large windows that invite natural light inside. A wooden deck extends from the entrance, providing a space for outdoor seating. A paved pathway leads to the front steps.
Cabin in Vance
4.89 out of 5 average rating, 209 reviews

Log home on Lake Marion inlet w/private dock.

Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Superhost
A spacious bedroom features a large bed dressed in white linens, complemented by decorative pillows. Nightstands with soft lamps are placed on either side. Wooden walls provide a rustic backdrop, with two windows adorned by patterned curtains allowing gentle light to filter in.
Bungalow in Summerton
4.78 out of 5 average rating, 116 reviews

The Turtle's Nest

Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

Top guest favorite
The exterior of the Farmhouse is showcased, featuring a spacious covered porch with comfortable seating and a welcoming entrance. Large windows allow natural light to fill the interior, and the surrounding landscape offers a glimpse of the tranquil rural setting.
Tiny home in Elgin
5 out of 5 average rating, 134 reviews

The Farmhouse @ Goat Daddy's

Nestled on 66 acres with a gorgeous pond/farm view, you will find Goat Daddy's Farm and Animal Sanctuary. Our luxurious tiny house has everything you need to make your farm stay comfortable and relaxing. Guests will have access to the farm during specific hours, as well as over 2.5 miles of paths and two ponds to explore. With your feet in the sand, by a fire, in the hot tub, on the trails, or getting some goat/animal therapy, The Farmhouse and Sanctuary has something to offer for all.

Top guest favorite
A charming cottage is framed by lush greenery, featuring a white exterior and a welcoming front porch. An American flag hangs from the porch, and potted plants add a touch of color. The structure is surrounded by a well-maintained lawn, giving it a serene appearance.
Cottage in Kingstree
4.88 out of 5 average rating, 102 reviews

Lovely Lavender Cottage

Ready to unplug in a Victorian cottage on a working cattle farm? Turn back the clock for a true cowboy experience. Sip coffee on the back porch while overlooking the back 40 with cows grazing and calves frolicking. Cozy up and star gaze by the fire pit in the yard or have a cocoa by the fireplace while you relax on our 200 acre farm deep in the woods away from the hustle. This is your place. Walk down the holly trail and gather wildflowers, unplug! Chickens & goats range the yard.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 166 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favorite
An aerial view captures the lakeside property surrounded by lush greenery and mature trees. The mobile home sits adjacent to the water, featuring a landscaped yard and access to a private boat launch. Nearby structures and pathways are also visible.
Home in Cross
5 out of 5 average rating, 31 reviews

Fish Haven

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

Guest favorite
The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.
Home in Summerton
4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 121 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Popular amenities for Santee lake access rentals

Quick stats about vacation rentals with lake access in Santee

  • Total vacation rentals

    Explore 20 vacation rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at $100 per night before taxes and fees

  • Verified guest reviews

    Over 50 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    20 of Santee vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests—averaging 4.9 out of 5!