
Santee vacation rentals
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Top-rated vacation rentals in Santee
Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for Santee vacation rentals
Santee house rentals

Cozy Col - home near downtown/ Fort Jackson/
Host was very reachable. Place was clean and maintained. Family of 4 with our pets fit and didn’t feel cramped. Worth the stay and easy to get to anywhere locally.

The Oasis
We stayed while visiting family in the area with our two boys. The space overall was perfect for our family of 4. It was close to all the places we were visiting and the hosts also provided great recommendations for restaurants. The neighborhood was very quiet as well! Only downside would be that the front room did not have black out curtains, otherwise a wonderful stay.

Charming Ranch House
The house is in a very nice location in a quiet neighborhood. It’s very well maintained and squeaky clean. The location is very good because you’re not far away from anything. We stayed at the house on a work trip so I didn’t cook much however I did fix my breakfast & the kitchen was equipped with everything I needed. Our host was very responsive and we will definitely stay there again. Highly recommended.

3/1.5 house in Cayce Close to USC, Ft Jackson, CAE
Joseph place was really comfortable and cozy. Joseph is a great host very responsive and accommodating. House has everything you need. Thanks Joseph!

2b/1.5bath brand NEW townhouse Closed to MUSC
This is the 2nd time I have stayed at this location in Florence. The place is very clean, comfortable beds, clean bathroom, and very easy to get into. The location was perfect for our needs, close to stores, food, and Francis Marion University. Wempy is a great host and very repsonsive. He answers mail within minutes and is always helpful. I would stay here again for sure. Thank you for a great stay!

LODGING @ OLD TOWNE LANDING SUITE A
Very nice house, quiet neighborhood. Also military friendly, would definitely stay again!!

Beautiful Home Away from Home Near Shaw AFB
Great location, we had no problems at all with this beautiful home and host!

Unit B: Whimsical 2-bedroom Home w/ Fast WiFi
5 Stars I stayed at Rayne and Palmer’s place for a full month, and the experience was excellent from start to finish. The space was clean, comfortable, and exactly as described. It felt like a true home away from home. Rayne was incredibly communicative and thoughtful throughout the stay—always available when needed but never intrusive. Check-in was smooth, the neighborhood was quiet and peaceful, and all the essentials were provided. I really appreciated the attention to detail and how everything was maintained—from trash and recycling to pest control and lawn care. It’s clear that they care about their guests having a great experience. If you’re considering a longer-term stay, I highly recommend this property. Thanks again for hosting us so graciously!
Other great vacation rentals in Santee

Welcome! a relaxing retreat...home away from home
Patricia home was lovely for my family and I. Really enjoyed the yard space and amenities provided

Beautiful lakefront condo overlooking Lake Marion.
Our stay was wonderful. Billie was always super responsive and accommodating. The place was exactly as posted. Plenty of room for me, my parents, and my two small kiddos. The location is great. Right on the lake. We caught some fish off the fishing dock. The walking bridge is super cool too. The pool was nice and clean. Would come back and stay here again.

Cheerful 3 bedroom home on the lake
Absolutely beautiful! The place was clean and inviting. The hosts had provided everything you could possibly imagine, even personal items if you forgot anything. There was so much to do for entertainment both inside and outside the home. We had a great time!

2 Beautiful Master Suites
Kathy’s place was very nice and comfortable. Close to Brecks where we got a 30 oz steak for $32.99 was not a fancy place, but it was worth it and the steak was awesome. Another place we ate on the way out was in Somerville. Shuckin shack oyster bar. They had a great menu low price for the best oysters, clams and mussels. Steamed or raw also a great fried cod sandwich. I am sure everything there was awesome!! Oh good Bloody Mary too! The proximity of Karen’s place to a lot of things to do was nice. She also left us much appreciated wine and a gift. Thank you Kathy for a great stay!

Lazy Days - Priv Dock,Kayaks,Arcades,Pet Friendly
Had a wonderful stay at this property! House was amazing! Very clean and great views on the lake. Nice screened in porch which was great to hang out on. Kitchen, living room, and bedrooms were all very comfortable. Scott and Lauren were both extremely helpful and checked in with us throughout the stay to make sure we had everything we needed. 5/5 would recommend and would stay again if in the area!

The Heron Lake House
The perfect stay! Beautiful lake, clean and gorgeous house, quiet neighborhood and amazing bang for your buck. We've stayed at a dozen Air B&B's and this was top 3! Plenty of space for our family of 5 (though could have EASILY fit another 3-5 guests). Never felt like we were falling over one another. Great fishing location (though we only caught one fish, haha), calm waters and breathtaking sunrise/sets. About an hour drive from the beach at Charleston (highly suggest Folly Beach). Morgan was responsive when we had questions and was always super kind.

Summerset The Heart of Lake Murray
We had a great weekend at this lovely lake house. Multiple outdoor areas to enjoy the water and the view! Loved the property and all it had to offer. Curt was a great host, as well!

Low Country Living by Low Country BNB
I can't say enough good things about Iris and this place! They were extremely kind and helpful. Would recommend staying with them anytime you are in the area! I know we will be!
Quick stats about vacation rentals in Santee
Total rentals
20 properties
Nightly prices starting at
$100 before taxes and fees
Total number of reviews
170 reviews
Family-friendly rentals
20 properties are a good fit for families
Rentals with a pool
20 properties have a pool
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Santee?
Yes! Work meets play with ease at over 10 vacation rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.
How much does it cost to stay in apartment rentals in Santee?
Experience the best of Santee with our apartment rentals, starting at about $190 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do apartment rentals in Santee have a gym?
Absolutely! We offer over 10 apartment rentals with a gym in Santee. Enjoy a tailored experience with all the comforts you desire.
Do apartment rentals in Santee have wifi?
Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.
Are there Santee apartment rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 10 apartment rentals with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!
Are there family-friendly apartment rentals in Santee?
Santee has more than 10 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
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