Vacation rentals in Saint Charles

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Saint Charles

Guests agree: these stays are highly rated for location, cleanliness, and more.

Private room near Historic Main Street
SUPERHOST
Private room · 2 guests · 1 bed · 1 shared bath

Private room near Historic Main Street

From $27 / night
Private Luxury Suite 2 Blocks From Main Street
SUPERHOST
Entire apartment · 2 guests · 2 beds · 1 bath

Private Luxury Suite 2 Blocks From Main StreetWelcome to the Bella Starr Suite in Old Town Saint Charles! Just two blocks from Historic Main Street and minutes from Lindenwood University, Streets of Saint Charles, Ameristar Casino and Frenchtown. STL International Airport is 12 minutes away. Come home and relax with plush linens, a 55" TV with HBO, sound system & board games. There is one queen bed and a single-sized pull-out sofa available for a guest. Laundry service for stays 7+ days. Stays 28+ days include weekly cleaning service.

From $84 / night
Katy Trail/St.Charles/PowerPlex/Tree View/Casino
Entire apartment · 6 guests · 2 beds · 2 baths

Katy Trail/St.Charles/PowerPlex/Tree View/CasinoSoak up the vibes of both St. Louis and St. Charles County. You'll have 2 comfy queen size beds and a king air mattress for additional guests. There is also dog park on site.

From $120 / night

Vacation rentals for every style

Get the amount of space that is right for you

  • Homes
  • Hotels
  • Unique stays

Popular amenities for Saint Charles vacation rentals

  • Kitchen
  • Wifi
  • Pool
  • Free parking on premises
  • Air conditioning

Other great vacation rentals in Saint Charles

SUPERHOST
  1. Entire cottage
  2. Saint Charles
The Rose Cottage -a short walk to Historic Main St
$110 per night
SUPERHOST
  1. Entire apartment
  2. Saint Charles
Brand New 2 Bedroom, 1 Bath near Main Street!
$95 per night
SUPERHOST
  1. Entire guest suite
  2. St. Louis
Entire Guest Suite With Private Entrance
$64 per night
  1. Private room
  2. University City
Delmar Loop, CWE, & Wide Street Parking
$25 per night
  1. Entire bungalow
  2. Saint Charles
Patio House, secluded in heartbeat of Main Street
$122 per night
SUPERHOST
  1. Entire house
  2. St. Louis
Sunny South City Guest House
$69 per night
SUPERHOST
  1. Entire guest suite
  2. St. Louis
Private Contactless Guest Suite
$63 per night
SUPERHOST
  1. Entire guesthouse
  2. St. Louis
1-of-a-Kind Tiny House in Heart of STL!
$56 per night
SUPERHOST
  1. Entire house
  2. Saint Charles
La Maison Charbonneau Near Old Town
$133 per night
SUPERHOST
  1. Private room
  2. O'Fallon
Treehouse Day Spas Penthouse in the Trees
$70 per night
SUPERHOST
  1. Entire apartment
  2. Saint Charles
Pop Luck's Guest Suite in Historic St. Charles ♥️
$93 per night
SUPERHOST
  1. Entire house
  2. Saint Charles
301GuestHouse Saveto 7nights!Retail storeDiscounts
$126 per night
Show all

Nearby destinations