Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

Guests agree: these stays are highly rated for location, cleanliness, and more.

Entire home · Defiance
The Niederschulte House
BACKYARD OASIS! Cozy and charming 1960 brick ranch with updated open floor plan and relaxing gazebo overlooking pond. Located on 3 private acres in Defiance area, near award winning Missouri wineries, Katy Trail State Park for hiking and biking, Daniel Boone home, and Busch Wildlife. Must be 25 years or older to book.
$225 per night
Entire cabin · Defiance
Hillside Cabin on 43 Acres w/ Private Lake & View!
Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!
$166 per night
Entire cabin · Defiance
NEW! ‘The Reubling House’ - Modern-Rustic Cabin!
Brimming with scenic spots, vineyards, and St. Louis thrills, this sleek 1-bedroom + loft, 1-bath cabin offers a true choose-your-own-adventure retreat. Walk to the Katy Trail, kayak in the Missouri River, and explore the Missouri Wine Country. At day’s end, return to the vacation rental that features a full kitchen, Smart TV, vintage bar, shared fire pit, and historic touches from the Reubling House’s early days — once owned and operated by August Ruebling, founder of the town of Defiance!
$146 per night

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Other great vacation rentals in Defiance

Entire rental unit · Defiance
'The Ruebling House' Historic Defiance Apartment!
$153 per night
Entire bungalow · Defiance
Wine Country Bungalow
$201 per night
SUPERHOST
Entire home · Augusta
Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!
$175 per night
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Tiny home · Pacific
Route 66 Cozy Cottage
$91 per night
SUPERHOST
Entire home · Augusta
Honey Ridge Hideaway- Historic Home with Vineyard
$549 per night
SUPERHOST
Entire home · Augusta
Quaint, Cozy & Quiet in Augusta
$156 per night
SUPERHOST
Entire home · Augusta
Cozy Augusta Home w/ Porch-Walk to Katy Trail
$140 per night
Entire guesthouse · Lake Saint Louis
Modern In-Laws Quarters with private entrance!
$149 per night
Treehouse · Dardenne Prairie
Treehouse Spa Suite
$75 per night
SUPERHOST
Private room · O'Fallon
Treehouse Day Spas Penthouse in the Trees
$75 per night
SUPERHOST
Tiny home · Pacific
Route 66 railroad shanty, a cozy artsy small space
$128 per night
SUPERHOST
Private room · Defiance
Katy Trail Bunkhouse2 at the Venue at Defiance
$70 per night
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