Vacation rentals in Defiance
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Top-rated vacation rentals in Defiance
Guests agree: these stays are highly rated for location, cleanliness, and more.
Entire home · Defiance
The Niederschulte House
BACKYARD OASIS! Cozy and charming 1960 brick ranch with updated open floor plan and relaxing gazebo overlooking pond. Located on 3 private acres in Defiance area, near award winning Missouri wineries, Katy Trail State Park for hiking and biking, Daniel Boone home, and Busch Wildlife. Must be 25 years or older to book.
$225 per night
Entire cabin · Defiance
Hillside Cabin on 43 Acres w/ Private Lake & View!
Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!
$166 per night
Entire cabin · Defiance
NEW! ‘The Reubling House’ - Modern-Rustic Cabin!
Brimming with scenic spots, vineyards, and St. Louis thrills, this sleek 1-bedroom + loft, 1-bath cabin offers a true choose-your-own-adventure retreat. Walk to the Katy Trail, kayak in the Missouri River, and explore the Missouri Wine Country. At day’s end, return to the vacation rental that features a full kitchen, Smart TV, vintage bar, shared fire pit, and historic touches from the Reubling House’s early days — once owned and operated by August Ruebling, founder of the town of Defiance!
$146 per night
