Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Top guest favorite

A spacious sleeping area features a large bed adorned with plush white pillows. Shelves display vintage cameras and decorative items, while ambient lighting is created by lamps on side tables. The walls are painted a soft blue, adding to the room's calm ambiance.

Tiny home in Pacific

4.96 out of 5 average rating, 262 reviews

Route 66 Railroad Shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Guest favorite

The living area features a unique ceiling with artificial greenery, complemented by rustic wooden walls. A white stone fireplace acts as a focal point, and a spiral staircase leads to the upper level. Decorative plants and bookshelves enhance the inviting ambiance.

Home in Pacific

4.93 out of 5 average rating, 149 reviews

Pacific Palace, super unique!

The Pacific Palace is unlike any other Airbnb! Located in the heart of downtown Pacific, Missouri - only 2 minutes from Highway 44 and 10 minutes from Purina. This house is an incredible one of a kind treasure with lots of unique features including: outdoor gazebo, fish pond, all original cedar interior design, two second story balconies, two large bat tubs (one located in the main bedroom) and so much more!!! Private parking and a gate for added privacy. Just minutes from Six Flags. Book today

Top guest favorite

A charming farmhouse is framed by lush green trees, displaying a welcoming front porch. The exterior showcases a muted gray siding with white accents, while a well-maintained lawn surrounds the home, enhancing the sense of tranquility in this rural setting.

Home in Augusta

4.98 out of 5 average rating, 253 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Top guest favorite

The exterior of a rustic log cabin is depicted at night, showcasing weathered wooden walls and large windows. A welcoming porch with a swing is adorned with a decorative red, white, and blue bunting. Lush greenery surrounds the cabin, illuminated gently by outdoor lighting.

Cabin in Saint Charles

4.98 out of 5 average rating, 350 reviews

Camp Mill Pond: Historic Cabin Near Main Street

*St. Louis Magazine A-List Winner!* ***PRESS: DESIGN STL, STL MAG, AND FOX2NEWS*** Camp Mill Pond is a throwback to the slow and easy rhythm of hot summer days. This circa 1835 cabin offers easy access to our historic area, including Main Street, Katy Trail for biking, and Frenchtown, without sacrificing modern comforts! This 180-year-old historic cabin sits on a beautiful lot, shared with our 1865 three-story home and a two-story carriage house. Ask about renting bikes and a golf cart!

Superhost

A modern bathroom features a vessel sink atop a wooden vanity with storage baskets below. Soft lighting illuminates the space, highlighting wood-paneled walls and slate-tiled flooring. A mirror above the sink reflects the tranquil atmosphere, with a glimpse of the living area visible through an open door.

Cabin in Defiance

4.95 out of 5 average rating, 128 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Top guest favorite

A vintage clawfoot tub is situated in a light-colored bathroom, accompanied by a simple shower curtain. A handheld showerhead is mounted above the tub, complemented by a metal shower caddy. Soft pink towels and a bath mat add a gentle touch to the space.

Home in Villa Ridge

4.93 out of 5 average rating, 116 reviews

Serenity Valley (No Cleaning Fee)

Discover serenity in this Studio 675 sq ft Airbnb amidst nature. Cozy space with 1 queen bed, optional inflatable queen bed for up to 4 guests. Amenities include WIFI, washer/dryer, full kitchen, DirecTV with parental controls. Vintage clawfoot tub, panoramic woods view. Family-friendly with a pack and play. Owners next door for quick resolutions. Relax on the deck. Just 60 mins from downtown STL, 15 mins from Washington, and 20 mins from Missouri wine country. Your tranquil escape awaits!

Guest favorite

A light-colored sofa is positioned in a living room, accompanied by a decorative lamp and a glass coffee table. A framed image of a Highland cow adorns the wall above the sofa. The space is bright and features doorways leading to other rooms.

Home in Villa Ridge

4.78 out of 5 average rating, 255 reviews

Sunny Modern Farmhouse - Pet Friendly Purina Farms

Our Coleman Road farm may look like a quaint older house from the outside, but inside you'll find a stylishly-updated modern farmhouse you'll be excited to spend time in. The rooms are filled with afternoon sunlight, and have been tastefully decorated to provide a tranquil and comfortable retreat. With a spacious living room, two bedrooms, a full bath, and separate kitchen and dining area, the space offers everything you need in a cozy and modern setting.

Guest favorite

Tiny home in Pacific

4.9 out of 5 average rating, 632 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- toys, books, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Top guest favorite

A modern bathroom is featured, showcasing a stylish blue vanity with gold fixtures. White towels are neatly arranged on a rack and a round mirror enhances the space. A glass shower enclosure displays white tiled walls, while a patterned floor adds visual interest.

Loft in Washington

4.99 out of 5 average rating, 383 reviews

2nd Street Loft - Riverview

Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Guest favorite

A wooden walkway leads to the entrance of the treehouse, flanked by lush greenery. The ramp features a sturdy railing, promoting accessibility to the inviting front porch area. Natural light filters through the trees, creating a serene atmosphere.

Guest suite in Dardenne Prairie

4.89 out of 5 average rating, 274 reviews

Treehouse Spa Suite

Treehouse Day Spa is nestled on 3 wooded acres in St.Charles County. Get away from it all while being close to it all at the same time. Augusta wineries, Main Street St. Charles and the Streets of Cottleville are all within minutes of the location! There are two rental units in the treehouse: The spa suite and the penthouse. They each have a separate entrance and are private spaces. Recharge your battery! Regroup Relax Refresh

Top guest favorite

The exterior of a restored early 1900s brick home is showcased, featuring a welcoming front porch with decorative planters. Large windows allow natural light to fill the interior. A well-maintained lawn surrounds the house, complemented by mature trees in the background.

Apartment in Washington

4.96 out of 5 average rating, 415 reviews

Elbert haus

The entire 2nd floor reserved to just one set of guest. Just three blocks from the Missouri Riverfront, historic downtown Washington, and near many fine restaurants. This early 1900s fully restored brick home offers a perfect place to lay your head after an exciting day. The house is located within walking distance of the Amtrak train station, close to the hospital and the trans Missouri Katy bicycle Trail.

Guest favorite

A tall wooden cabinet features intricate detailing and is topped with a decorative arrangement of colorful plants and a circular art piece. Natural light filters in through nearby windows, highlighting the rich textures of the exposed brick wall and wooden beams above.

Home in Augusta

5 out of 5 average rating, 124 reviews

Augusta Haus

This early 1850's Augusta home has been lovingly revitalized to help those who stay here capture the essence of Augusta. While we have highlighted the craftsmanship of the original builder, we have also incorporated our vision of a comfortable historic home in the very heart of Missouri wine country. Great for couples as well as those traveling with friends or children. Relax and enjoy our Augusta Haus!

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Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Other great vacation rentals in Defiance

A spacious bedroom features rustic wooden walls and a high ceiling with exposed beams. A king-sized bed with white linens is centered in the room. Two nightstands with lamps sit on either side, and a vintage rug adds warmth to the hardwood floor.

Cabin in Augusta

4.8 out of 5 average rating, 10 reviews

Rustic Augusta Cabin by StayLage

Guest favorite

Home in Boles Township

4.9 out of 5 average rating, 31 reviews

Serene 4BD/4BA Countryside +Hot Tub by Lake & Golf

The exterior of The Reserve Guest Cottage is displayed, featuring a welcoming green façade and decorative shutters. A sign is prominently positioned, indicating the cottage name and contact information. Steps leading up to the entrance are flanked by subtle landscaping, creating an inviting approach.

Cottage in Augusta

4.75 out of 5 average rating, 83 reviews

The Reserve Guest Cottage

Top guest favorite

A golden retriever stands on a gravel path, leading towards a stone gate. In the background, a red barn is visible against a vibrant sunset sky, with soft pink and purple hues illuminating the clouds. Lush green hills surround the area.

Barn in Gray Summit

5 out of 5 average rating, 5 reviews

Restoration Ranch Studio

A modern kitchen with a farmhouse style features light-colored cabinetry and open shelving. Stainless steel appliances are complemented by a spacious sink. A dining table surrounded by checkered chairs is positioned near large windows, allowing natural light to illuminate the rustic wood flooring.

Apartment in Defiance

4.83 out of 5 average rating, 24 reviews

'The Ruebling House' Historic Defiance Apartment!

Guest favorite

A cozy outdoor seating area features four cushioned chairs arranged around an ornate table. The patio overlooks a lush wooded landscape, offering a peaceful retreat. A spacious deck above provides additional outdoor space, enhancing the connection to nature.

Home in Labadie

5 out of 5 average rating, 6 reviews

Pointer Haus | Dog Friendly, near Purina Farms, Wa

Top guest favorite

An open-concept living area showcases rich wooden beams and rustic charm. A comfortable leather sofa and a coffee table sit on a patterned area rug, while a cozy sitting area is visible in the background. A staircase leads to the upper level, adding architectural interest.

Home in Wildwood

5 out of 5 average rating, 21 reviews

3 private acres, Koi fish pond, garage parking

Superhost

An inviting entrance is seen featuring a wooden door ajar, revealing a glimpse of the interior. Dark chairs are arranged on a stone patio, accompanied by a small side table. The rustic stone and wooden exterior reflects the historic charm of the cabin.

Guest suite in Washington

4.6 out of 5 average rating, 5 reviews

Moon Claw Suite @Raven'sViewRetreat in WashMO

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Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Nightly prices starting at
$70 before taxes and fees
Total number of reviews
340 reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
August A. Busch. Memorial Conservation Area, Weldon Spring Conservation Area, and Chandler Hill Vineyards

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Vacation rentals for every style

Popular amenities for Defiance vacation rentals

Other great vacation rentals in Defiance

Quick stats about vacation rentals in Defiance

Total rentals

Nightly prices starting at

Total number of reviews

Wifi availability

Popular amenities

Local attractions

Destinations to explore