Vacation rentals in Florence

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Top-rated vacation rentals in Florence

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Private room · Florence
Welcome to the Big House!
Centrally located home in Florence SC. This is my private home with studio apartments/mother-in-law suites. Each unit is rented individually which includes private bathroom, kitchenette area, parking, and entrance to the unit. The units are not shared spaces you will be given full privacy to the unit during your stay.
Mar 13 – 20
$43 per night
Guest suite · Florence
Cozy One-Bedroom Suite with Private Entrance
Come relax and unwind in this inviting one-bedroom suite with a queen sized bed. Enjoy the dining area with complimentary coffee bar or kickback with a good book on the new couch. It also includes a spacious closet, TV with streaming services, and private bathroom with walk-in shower.
Mar 3 – 10
$49 per night
Home · Florence
Pineapple House: Historic. Southern Charm. Walk Downtown.
Welcome to the Pineapple House! Experience southern hospitality in this newly renovated historic charmer perfect for professionals. Morning coffee on the front porch. Off street parking, laundry room, 2 Roku TV's, queen sleeper sofa, large fenced backyard w/ fire pit. Great location in quaint, quiet downtown Florence neighborhood. Walkable to restaurants. 3 min to FMU Performing Arts Center. 5 min to McLeod. 10 min to FMU & MUSC Medical Center. Extended stays welcome!
Nov 30 – Dec 7
$93 per night
Superhost

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Stay near Florence's top sights

Photo of Red Bone Alley Restaurant
Red Bone Alley Restaurant9 locals recommend
Photo of Tubb's Shrimp and Fish Co.
Tubb's Shrimp and Fish Co.7 locals recommend
Photo of Julia 4
Julia 44 locals recommend
Photo of Wholly Smokin' Downtown
Wholly Smokin' Downtown7 locals recommend
Photo of Harris Teeter
Harris Teeter5 locals recommend
Photo of Timrod Park
Timrod Park4 locals recommend

Other great vacation rentals in Florence

Private room · Florence
Craft house Apt B
Oct 28 – Nov 4
$41 per night
Superhost
Apartment · Florence
Upstairs vaulted studio B downtown
Oct 7 – 14
$74 per night
Superhost
Guest suite · Florence
Private Apartment 5 Min Away From I-95 & McLeod
Dec 31 – Jan 7
$162 per night
Superhost
Guesthouse · Florence
*No Cleaning Fee* Downtown Boho - Near I95/I20
Nov 28 – Dec 5
$72 per night
Superhost
Private room · Florence
The Craft House
Nov 22 – 29
$45 per night
Superhost
Home · Effingham
3B/2B w/Garage Welcome to Your Home Away From Home
Dec 10 – 17
$99 per night
Superhost
Farm stay · Timmonsville
The Cottage at Dream Acres & Petting Zoo I-95/I-20
Mar 16 – 23
$110 per night
Superhost
Private room · Florence
Bobby & Ethan’s Crystal Home Stay, SC
May 5 – 12
$48 per night
Superhost
Guesthouse · Florence
Hide Away Studio Guesthouse
Feb 12 – 19
$48 per night
Superhost
Home · Florence
Kuker Cottage Downtown Florence-Near I95 & I20
Mar 11 – 18
$105 per night
Superhost
Guesthouse · Florence
Midtown Retreat - Guest House in heart of Florence
Nov 11 – 18
$86 per night
Superhost
Cottage · Timmonsville
*Relax and Refresh Cottage-Near I-95 and Florence*
Jan 7 – 14
$143 per night
Superhost