
Hotel vacation rentals in Downtown
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Top-rated hotel rentals in Downtown
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Downtown hotel rentals
Family-friendly hotel rentals

Downtown San Diego Stay Near Gaslamp Quarter

Stylish South Bay Home

Perched right on the sand in Pacific Beach

Budget-Friendly Stay w/ Easy Access to SeaWorld

Walkable Little Italy + Rooftop Dining. Free Bikes

MCRD Grad Hotel Room - Breakfast

Hit the Trails in La Mesa + Free Breakfast & Pool

Standard King, Ground Floor - Sea Harbor Hotel
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Iconic Resort in San Diego

2 Pet-friendly Rooms—Minutes to Mission Bay Beach

Pet-friendly Hotel with Free Breakfast and Pool!

Beachfront Stay | 1 Unit | Near La Jolla Cove

Playful escape near games & concerts at Petco Park

Downtown Delight: Pets Allowed, Parking, Pool!

Comic-Con 2026 in San Diego @ Marriott Pulse Suite
Hotel rentals with a patio

Spacious 1 BR@ Mission Valley Worldmark

Coronado Beach Resort

Modern King Room | Luxe Stay in Little Italy

Club Wyndham Harbour Lights

Bamboo Garden Event (40 cap) 2 TVs. 2 BBQ. Chairs.

Comic-Con 2026: Spacious King Suite + Sofa Bed

2 bd/2 bth Resort Style Hotel

Worldmark Studio Sleeps 4
Quick stats about hotel rentals in Downtown
Total rentals
290 properties
Nightly prices starting at
$20 before taxes and fees
Total number of reviews
4.6K reviews
Family-friendly rentals
90 properties are a good fit for families
Pet-friendly rentals
150 properties allow pets
Rentals with a pool
120 properties have a pool
Destinations to explore
- Fitness-friendly rentals Downtown San Diego
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- Rentals with a sauna Downtown San Diego
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- Rentals with a home theater Downtown San Diego
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- Family-friendly rentals Downtown San Diego
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- Hostel rentals Downtown San Diego
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- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Tijuana Beach
- Pacific Beach
- SeaWorld San Diego
- University of California San Diego
- LEGOLAND California
- Coronado Beach
- San Diego Zoo Safari Park
- Balboa Park
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Belmont Park
- Liberty Station
- Black's Beach
- Moonlight Beach
- Sesame Place San Diego
- Law Street Beach
- Torrey Pines Golf Course
- Mission Beach
- Santa Monica Beach
- USS Midway Museum
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