House vacation rentals in Saint Charles

Find and book unique houses on Airbnb

Top-rated house rentals in Saint Charles

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Top guest favorite

A vibrant living room showcases an orange sectional sofa, colorful rug, and playful wall art. Shelves with decorative items are visible, along with a console table featuring a neon sign. Light streams in through windows, illuminating the contemporary design elements.

Home in Beaverdale

4.96 out of 5 average rating, 183 reviews

MidCentury, technicolor Ranch w/yard, w+d, parking

- Ranch home in Des Moines' friendly Beaverdale neighborhood - Steps from grocery store, ice cream shop+dining - Blocks to more dining+shops - Less than 5 minutes from Drake University - Around 10 minutes from downtown, Des Moines, Arts Center, parks - Easy access within 15 minutes to suburbs - 1000+ feet with open living, dining and kitchen, 2 beds, 1 bath, laundry and on-site parking - Outdoor front porch, back patio+fire pit - Perfect for a family or two couples ***Send your special requests!

Top guest favorite

A view into the living and dining area reveals a wooden dining table surrounded by white chairs, with a cozy seating arrangement featuring a patterned couch across the room. Natural light fills the space, highlighting the wooden flooring and built-in shelves.

Home in Des Moines

4.99 out of 5 average rating, 159 reviews

Remodeled Brick Home close to everything

Your family will be close to everything when you stay at this centrally located home. Located one mile from the Des Moines Airport (stay and Park possible) next to a main street just three short miles to downtown. Multiple restaurants and grocery stores within walking distance. Near Des Moines Water Works Park and Grays Lake recreational area. Newly renovated top to bottom. Includes two spacious bedrooms on the main floor and two bedroom areas in the basement, and a full bathroom on each level.

Top guest favorite

An open-concept living area features natural wood beams and polished concrete floors. A spacious sectional sofa with patterned cushions offers seating, while a grand piano is visible in the background. A glass dining table is situated nearby, creating a welcoming space for gatherings.

Home in Urbandale

4.92 out of 5 average rating, 140 reviews

RARE Mid-Mod Home. Spacious inside-and-out.

Don't miss your chance at this unique mid-century modern home located in the heart of Des Moines where you'll be just minutes from many local restaurants, bars and area attractions. Entertain your guests with 3,600sf of open-concept mid-century living while enjoying all the amenities this house has to offer! Relish in billiards indoors or escape outdoors for yard games, grilling or an evening bonfire. This newly remodeled 4 bed, 2.5 bath property has everything you need on your next vacation.

Guest favorite

The living space features a modern gray sectional sofa complemented by a green armchair. A coffee table rests on a patterned rug. Two floral artworks adorn the wall, while warm lighting is provided by standing lamps. Natural light enters through multiple windows.

Home in Des Moines

4.94 out of 5 average rating, 279 reviews

Cozy Historic Escape

This comfortable bungalow is stylish with historic charm. The front porch is perfect for morning coffee. The main living space has original hardwood floors and classic brick fireplace with craftsman style built-ins. The house also has fenced in backyard with patio for enjoying temperate days. It is centrally and conveniently located close to Des Moines Playhouse, ~6 minutes from Wells Fargo Arena and Downtown Des Moines, ~13 minutes to Jordan Creek Town Center, and ~15 minutes to DSM Airport.

Top guest favorite

The exterior of the house features a welcoming front porch, surrounded by a well-kept garden and lush green grass. A mix of architectural styles is visible, with a combination of siding colors and textures, inviting guests to relax in the serene outdoor space.

Home in Des Moines

4.99 out of 5 average rating, 184 reviews

Peaceful Setting & Modern Style

Escape the hustle and bustle of the city and retreat to your own private oasis with this charming 2 Bedroom Airbnb. The house provides present-day amenities while still honoring the original 1930s character. You’ll enjoy a new and sparkling clean kitchen, complete with all the appliances and utensils you need. The bathroom, laundry, dining room, reading nook and living room have all been beautifully updated as well, ensuring that you'll feel right at home from the moment you arrive.

Top guest favorite

A balcony view reveals a vibrant sunset casting shades of pink and orange across the sky. Silhouetted trees frame the scene, with distant buildings emerging in the background. A round glass table with colorful cushions offers a place to enjoy the view.

Home in Des Moines

4.97 out of 5 average rating, 142 reviews

Woodland Heights hist. district house on the hill.

Beautiful historic duplex house in the heart of woodland heights. Walking distance to downtown and next to Ingersoll avenue which is full of shops, bars, restaurants and more. Our place allows 2 parking spots on site with a side entrance to your upstairs Airbnb. The 800+ sq ft space includes a private kitchen, bathroom, bedroom, living room, and balcony with views of downtown. Picnic table and grassy area below balcony can be used on those nice Iowa days.

Top guest favorite

A single-story home is surrounded by a lush green lawn, featuring a prominent tree and well-maintained landscaping. The attached two-car garage is visible, and the driveway provides ample parking space. The house's exterior combines light siding with a brick accent, creating a welcoming appearance.

Home in Perry

4.94 out of 5 average rating, 165 reviews

Sunset View Ranch 5-Bedroom House

This mind blowing Sunset View Ranch has just what any family would want for a weekend to relax! There are 5 bedrooms to sleep 10 people comfortably or 6 singles. Fully equipped kitchen. 2 acres of open space for the kids, including a small basketball court to play on. We have made it our mission to make sure our guests stay in a healthy environment. The interior of the house is cleaned and disinfected on each Monday or after our guests leave.

Top guest favorite

A vibrant sitting area features a plush pink couch adorned with decorative pillows. Framed floral artwork decorates the walls, complemented by a lamp and a wooden table. A glimpse of a desk and additional seating can be seen in the background, enhancing the eclectic decor.

Home in Des Moines

4.99 out of 5 average rating, 100 reviews

White Oak Hillside Oasis

Our 3 bedroom hilltop 1950’s home with wonderful views of the capital and city of Des Moines is the perfect place for your stay. Nestled just south of downtown in a quiet historic Italian neighborhood, you are within walking distance from a world class brewery, bars, restaurants and miles of walking and biking trails surrounding Gray’s Lake. We are within a few miles of everything else that the downtown area of Des Moines has to offer!

Guest favorite

The exterior of a single-story house is visible, featuring a well-maintained lawn and a paved driveway leading to an attached garage. The front porch is adorned with a railing, and a mix of trees and shrubs frames the property, creating a pleasant neighborhood ambiance.

Home in Creston

4.83 out of 5 average rating, 125 reviews

House in Creston

Relax with the whole family in this cute cozy house. The house sits on a large corner lot in a quiet neighborhood. 3 bedrooms, 1 king and 3 single beds. Even a toy room for the little ones. Relax in one of the 4 recliners and watch a movie on the big screen tv. Plenty of room to park the boats, electric for charging available and a fish cleaning table is available. Perfect place for your hunting or fishing trip. Pets welcome

Top guest favorite

A well-furnished living area features two sofas and an accent chair arranged around a central coffee table. Natural light floods in through large windows, highlighting a cozy fireplace and elegant decor on the shelves. Wood flooring adds warmth to the inviting space.

Home in Urbandale

4.96 out of 5 average rating, 111 reviews

Suburban Oasis with Hot Tub

Sleeping 12 people, 4 bedrooms, 7 beds, 3.5 bathrooms, this comfortable suburban home offers a new hot tub with Bluetooth speakers, and fenced in yard. Walk out basement includes an air hockey table, day bed, recliners, and separate kitchen area with new mini fridge to relax day to night with the family. Fiber WiFi available and smart TVs in the living areas to enjoy any entertainment. This home is the ideal place to gather.

Top guest favorite

A living area presents a mix of brown leather accent chairs and a gray fabric sofa, adorned with decorative cushions. A wooden coffee table sits centrally on a light area rug, while plants are displayed on a wall-mounted rack. Natural light filters through the window, covered by dark curtains.

Home in Creston

4.99 out of 5 average rating, 110 reviews

Uptown BnB - Creston, IA

Located in uptown Creston, your family will be close to everything when you stay at Uptown Bnb! -Sleeps 8 guests -Walk to uptown Creston -4 Total beds with 1 pullout couch -3 Bedrooms & 2 full baths -Fully Equipped Kitchen -Gas Grill -High-Speed Wifi -Live TV streaming with Hulu -Keyless Entry -Private parking for 1 car + free street parking

Superhost

Home in Des Moines

4.85 out of 5 average rating, 110 reviews

6 Bedroom/3 Bath/10 beds @ Waterbury White House!

The White House is a newly updated home in the heart of Des Moines with trendy decor and comfortable furnishings! Perfectly situated off I-235, your only minutes to where you need to be. Conveniently located next to White Willow Event Center, along with several bars and restaurants within walking distance. Note: no more than 2 pets