
Villa vacation rentals in Panama
Find and book unique villas on Airbnb
Top-rated villa rentals in Panama
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama villa rentals
Private villa rentals

Charming & Quiet villa

Casa Laguna - luxury beach front house with pool

Beachfront Property is Your Own Piece of Paradise

Casa Almendra

On the Beach Villa in Boca Chica!

The Golf Oasis Villa by AcoModo

Villa Helena 2 Bedrooms Cerro Azul

Mountain villa with breathtaking views of Boquete
Luxury villa rentals

Privatization Villa 17 people | Vacation - Events

Beach House Where Emy

Bocas Overwater Luxury Villa & Lodge

Beachfront Villa with Pool at the Heart of Venao

Cozy Villa in Playa Escondida

Casa Caracola. Luxury villa. 200 mts from beach

Breathtaking Views Mansion w/King Beds

@Villa SharonBeach House in Playa Blanca, Farallon
Villa rentals with a pool

Villa Playa Caracol, 3 Bedrooms, Pet Friendly

Villa La Vista-Panama's majestic mountain hideaway

Caribbean Beach House with Pool

Stunning Oceanfront 4-Bdrm Villa w/ Infinity Pool

Rare Luxury Villa & Casitas, Pool, Bocas del Toro.

Casa Helechos, in a beach community with a swimming pool

Beach house in Punta Chame, Villa frente al mar

Unique beachfront property w/pool & amazing views
Destinations to explore
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Family-friendly rentals Panama
- Rentals with beach access Panama
- Hotel rentals Panama
- Nature eco lodge rentals Panama
- Pet-friendly rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Rentals with a sauna Panama
- Treehouse rentals Panama
- Boat rentals Panama
- Bungalow rentals Panama
- Beach house rentals Panama
- Dome rentals Panama
- Smoking-friendly rentals Panama
- Chalet rentals Panama
- Cottage rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Island rentals Panama
- Rentals with a hot tub Panama
- Fitness-friendly rentals Panama
- Rentals with breakfast Panama
- Rentals with an accessible height bed Panama
- Waterfront rentals Panama
- Rentals with a fireplace Panama
- Shipping container rentals Panama
- Townhouse rentals Panama
- Farmstay rentals Panama
- House rentals Panama
- Condo rentals Panama
- Tiny house rentals Panama
- Lakehouse rentals Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Apartment rentals Panama
- Rentals with lake access Panama
- Rentals with a fire pit Panama
- Loft rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Boutique hotel rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Rentals with a home theater Panama
- Rentals with pools Panama
- Bed and breakfasts Panama
- Rentals with a patio Panama
- Family travel hub Tips and inspiration
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- Outdoor adventure Explore nature with the family
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- Kid-friendly state parks Check out these family-friendly hikes