
Vacation rentals in O'Brien
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in O'Brien
Guests agree: these stays are highly rated for location, cleanliness, and more.
0 of 0 items showing
1 of 3 pages
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for O'Brien vacation rentals
Other great vacation rentals in O'Brien
Top guest favorite

Home in High Springs
4.9 out of 5 average rating, 62 reviewsThe Great Outdoors House | Experience High Springs
AndreaRating, 5 stars2 weeks ago
Had a wonderful weekend, the resturants were great, the downtown square was so darling we really enjoyed actually getting to get out and enjoy everything around us, everyone was super friendly and thw house was exactly as described and very well kept. we couldnt of asked for more!
Superhost

Home in Chiefland
4.85 out of 5 average rating, 27 reviewsSunsethilltopfarm
KimRating, 5 stars4 months ago
We had a wonderful stay at this Airbnb! The host was excellent, with fantastic communication from start to finish. The house was in the perfect location for our needs, making everything so convenient. One of the highlights of our stay was the host’s farm! They gave us a tour, and we got to see adorable goats, ducks, and a beautiful vineyard —it was such a unique and delightful experience. The thoughtful touches really stood out: they left us farm-fresh eggs, a pizza, a snack basket, a bottle of wine, and even a birthday balloon, which made our stay feel extra special and welcoming. The only downside was the master bedroom shower, where the water pressure was low due to some older hardware that could use an update. Overall, it was a very enjoyable and memorable experience, and we would happily recommend this Airbnb to others!
Superhost

Home in Fort White
4.88 out of 5 average rating, 17 reviewsGolden Girls Spring Retreat 2
ThomasRating, 5 stars1 month ago
Host had a few condiments in refrigerator and even eggs! She was very friendly and I’d stay there again.
Top guest favorite

Camper/RV in Old Town
4.92 out of 5 average rating, 62 reviews*Nature Lovers, Springs, River, Gulf- 5Guests-LUX!
RachelRating, 5 stars6 days ago
When we arrived, there was music playing, flameess candles, and a sound machine going in the room . It was a very lovely touch. We had a great night sleep and my partner woke up to stepping outside and he saw deer which was a magical experience.. would definitely come back if we were to be in the area.
Superhost

Home in Jasper
4.83 out of 5 average rating, 6 reviewsSweet Retreat
GaryRating, 5 stars5 months ago
Very secluded, quiet and peaceful. If you do not mind deer and turkeys wandering around the property, this is the place for you. It's a simple life kind of place. We love it!
Guest favorite

Home in Live Oak
4.92 out of 5 average rating, 74 reviewsNorthern Florida Country Home
AaciniRating, 5 stars5 days ago
lo recomiendo 👍 mucho 100xciento
Top guest favorite

Home in Gainesville
5 out of 5 average rating, 21 reviewsPool, 10 guests, near stadium, family-friendly
LoriRating, 5 stars5 days ago
My family had an AMAZING stay at this lovely home! It’s in a perfect location inside of a quiet neighborhood. The home is exactly as pictured, and the backyard is stunning! The host went above and beyond to answer any questions we had and to help us with any thing we needed. Highly recommend this property and we will definitely be back! Thank you so much for hosting us!
Guest favorite

Home in High Springs
4.92 out of 5 average rating, 71 reviewsGinnie Springs Hidden Paradise (16+ guests)
KatieRating, 5 stars1 week ago
This property was absolutely beautiful! Very spacious and comfortable. I will definitely be booking this property again and will recommend this listing to my friends looking to have a peaceful getaway. Thank you!
Destinations to explore
- Saint Johns River Vacation rentals
- Orlando Vacation rentals
- Four Corners Vacation rentals
- Tampa Vacation rentals
- Central Florida Vacation rentals
- Kissimmee Vacation rentals
- Seminole Vacation rentals
- St Petersburg Vacation rentals
- Tampa Bay Vacation rentals
- Panama City Beach Vacation rentals
- Destin Vacation rentals
- Florida Panhandle Vacation rentals
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Ginnie Springs
- Manatee Springs State Park
- Gilchrist Blue Springs State Park
- Madison Blue Spring State Park
- Ichetucknee Springs State Park
- Florida Museum of Natural History
- Keaton Beach
- Shired Island Trail Beach
- Depot Park
- Adams Beach, Florida
- Horseshoe Beach Park
- Suwannee River State Park
- Fanning Springs State Park
- Ironwood Golf Course
- Suwannee Country Club
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes