Colleton County vacation rentals

4.97 out of 5 average rating, 124 reviews

Cottage in Beaufort

Bright Dreamy Cottage w/ Fenced Yard & Beach Pass

Experience the best of Beaufort in this charming, newly built 3 bedroom, 2 bathroom home in the heart of the Historic District! This is the perfect space to call home during your Beaufort trip. You will love both the front and back porches and stylish indoor spaces, soaked in natural light. Only 4 blocks from the water and under a mile to Bay Street shopping/dining district, and waterfront park, this is the ideal spot to get away and enjoy some sun, rest, and relaxation. 20 mins to Parris Island

Top guest favorite

Condo in Saint Helena Island

5 out of 5 average rating, 43 reviews

The Pink Pelican

Thank you so much for choosing The Pink Pelican, a coastal villa, located on Harbor Island and steps from the ocean. This private beach and community provide a family friendly and peaceful low country vibe. From the serene beaches, fresh seafood, and southern hospitality, it’s the perfect family vacation spot or romantic getaway. Also, the charming town of Beaufort is just minutes away where you can enjoy fine southern cuisine, shopping boutiques, and refreshing cocktails by the waters edge.

4.8 out of 5 average rating, 15 reviews

Home in Edisto Island

Modern Edisto Beach Cottage

This stylish, modern 1BR, 2-story condo is just a 5-min drive / 15-min walk to the beach and located on a resort & golf club! Sleeps 4 with a queen bed + pullout couch. Enjoy a kitchen, fast Wi-Fi, & smart TV. Guests can purchase resort amenity passes separately for access to pools, tennis courts, minigolf, gym, & more. Whether you’re here for a romantic getaway, a golf weekend, or a beach retreat, this condo is your home base for Lowcountry living. Per HOA rules, pets aren’t allowed.

A modern living area is presented with a grey sofa and two distinct striped armchairs, facing a round glass coffee table. Natural light illuminates the space, complemented by warm ceiling lights. A kitchen area is visible in the background, featuring stainless steel appliances.

5 out of 5 average rating, 3 reviews

"Four Oaks" 3/2 in Beaufort

Come SEA Mermaid Cottage's newest Vacation Rental! LOCATION, LOCATION, LOCATION! Nestled under the Oaks, this Cottage is sure to impress and provide comfort, rest and relaxation during your stay. Sleeps 6 comfortably. Nearby Spanish Moss Trail. Spend the day at Pigeon Point Park and don't forget to soak up the evening sky on the dock at Pigeon Point Boat Landing. Shopping and Fine Dining in Historic Downtown Beaufort is about a mile away and you are a short distance to MCRD Parris Island!

4.98 out of 5 average rating, 101 reviews

Home in Edisto Island

Marshfront Villa In The Trees - Near Beach & Bay

"The most unique and relaxing place to enjoy the tranquility and experience of Edisto. We did not want to leave" - Sambo Nestled atop 360-degree marsh views, you'll be immersed in the exotic natural beauty and wildlife of the Edisto sea island. Hear the waves crashing at the beach from the front porch and watch the marsh tides rise and fall from your choice of the many porches. "Nature with luxury.. our group loved floating from the house out to the inlet for private beach days" - JP

4.91 out of 5 average rating, 32 reviews

Charming Beaufort Home

Feel the warm South Carolina breeze and total relaxation wash over you at this classic home in Beaufort. This 3-bedroom, 2.5-bathroom vacation rental is the perfect place for friends and family to gather for a stress-free trip. Take the Spanish Moss Trail to downtown Beaufort where you can stroll along the waterfront, pop into quaint shops, or enjoy fresh seafood at one of the local restaurants. Just a day trip away, you’ll also find easy beach days waiting for you on the nearby islands.

Apartment in Edisto Island

The tranquil scene depicts a calm waterway surrounded by lush greenery and trees, reflecting the clear blue sky. A wooden structure is partially visible to the left, blending harmoniously with the natural landscape.

4.81 out of 5 average rating, 26 reviews

Sea Cloud Serenity

Charming first-floor condo in the gated Wyndham Ocean Ridge. Well-equipped kitchen for preparing quick snacks or evening meals. The back deck is perfect for starting your day with a cup of coffee or ending it with a glass of wine. With the beach less than a mile away, you'll have easy access to breathtaking coastal beauty. Indulge in delicious seafood or Southern cuisine at the local restaurants in the area. Book your stay today for a peaceful and relaxing vacation and lasting memories.

4.96 out of 5 average rating, 178 reviews

A serene outdoor setting features a cozy fire pit with firewood arranged inside. Two turquoise Adirondack chairs are positioned nearby, inviting relaxation. A winding stone path leads to a charming house with a spacious porch, surrounded by lush greenery and Spanish moss-draped trees.

Cottage in Beaufort

Peaceful River Retreat Near Historic District

This tranquil, private, river retreat has incredible views of the marsh and the Beaufort River. Located in popular Pigeon Point, you are just a short bike ride or a 20 minute walk to the historic district and downtown Beaufort. I also have another more glamorous and exotic property next door see it at: airbnb.com/h/motm Enjoy fishing and crabbing right in your back yard at high tide or take a short walk down to the boat landing where you can watch people hand cast nets for shrimp!

A welcoming living area features pastel green walls and a mix of modern and cozy furnishings. A large, colorful upholstered ottoman is situated at the center, surrounded by a curved sofa and accent chairs in soft tones. Ample natural light streams in through multiple windows.

5 out of 5 average rating, 8 reviews

Midnight Moon Retreat

Featured on Happy to Be Home with the Benkos on the Magnolia Network, this 2BR, 2.5BA retreat sleeps 6 guests and blends historic charm with artistic design. Custom reclaimed wood cabinets, painted floors, and handcrafted Talavera tiles add unique character. Perfectly situated in the historic district of Beaufort, making this home centrally located to all main attractions. Hunting Island Park pass included! Enjoy a fresh exterior and a welcoming front porch. Book your stay today!

4.9 out of 5 average rating, 157 reviews

A wooden sign with the phrase 'KEEP CALM & BEACH ON' is placed on a white surface. A clear lamp and a potted plant are seen in the background, adding a touch of greenery to the room's decor.

Condo in Edisto Island

A Room With a View. Recently Renovated Condo!

If you are looking for a comfortable, easy to access, quiet getaway, then you have found it. This pristine, recently refurbished studio condo has everything you need. Huge 12x12 deck offer additional outdoor space for relaxing. On the 9th green of the Plantation Course. Short walk or bike ride to the beach. You will love the location and the space. Very close to The Waters Edge coffee shop, Ella & Ollies, bike rentals. Sister property to All Inn on Edisto and Cozy Edisto Condo.

4.91 out of 5 average rating, 164 reviews

An outdoor deck area features two wicker chairs with light-colored cushions and a small matching table. The surrounding greenery includes tall palm trees and a well-maintained lawn, creating a serene outdoor space for relaxation.

Condo in Edisto Island

422 Oristo Lodge

This Newly Renovated 1BR/ 1BA Efficiency Is Perfect For Escaping The Mainland Hustle And Bustle. Located Inside Ocean Ridge Resort On Edisto Beach, SC This Villa Has Many Features To Make Your Stay Relaxing And Comfortable. Queen Size Bed, Full Kitchen( Stove/Oven, Refrigerator, Microwave), Full Bath, Washer/Dryer, Cable Tv, Large Sundeck. Bed and Bath Linens Are Provided As Well As Departure Cleaning For Your convenience.

An open living area features a cozy seating arrangement with a television and two lamps illuminating the space. Large windows allow natural light to fill the room. A dining table is positioned near the kitchen, which showcases a countertop and storage cabinets.