Vacation rentals in Cairo

O’s Barn Cabin - Small Town Livin'!

O’s Barn Cabin offers a simple and unique way of relaxing in rustic fashion! Our pet friendly tiny home is 532 sq. ft of open space and country character. The location is out of the city, yet just a couple miles from all of the stores you need. The little cabin is nestled down our shared private and peaceful driveway, with views of cattle grazing in the pasture right off the front porch at the right time of year. Our big screen projector and fire pit are two amenities you'll be sure to enjoy!

Eagle’s Crib, a chic studio in Fayette | CMU

Charming Industrial-Chic Bungalow Studio in Historic Fayette Welcome to your cozy home away from home! This newly restored bungalow studio features a stylish industrial-chic design and is perfectly located in Fayette’s historic district. Brand-new interior, just steps from Central Methodist University and downtown Fayette. Quick drive to Katy Trail and Columbia. Whether you’re here for a college visit, a weekend getaway, or just passing through—this inviting studio has everything you need!

Rural farm house in country setting

Take it easy at this unique and tranquil getaway. Home sits next to a barn, pond, old oak tree and surrounded by nature. Unplug and enjoy the many outdoor experiences with an old four-room farm house. The one bedroom has a full bed, full futon, 3/4 bathroom, tv, and dresser. The family room has a rocker, queen sofa sleeper, tv, wii, DVD player and antenna TV. A full kitchen is off family room with a 3-seasons room and deck overlooking back of property. Day and night wildlife experiences.

Briggs Convenience Haven

Enjoy this modern newly updated 3bed 2 bathroom home in picturesque Macon. With 3 soothing queen beds, 2 terrific bathrooms with bathtubs, and a cozy living room with 2 pull out sofas. This property is perfect for a relaxing getaway. Guest can enjoy amenities like AC, Wifi, and washer and drying machine during their stay. Property is also located close to 2 grocery stores and Wal mart. As well as many other restaurants. We hope you enjoy what our place and Macon has to offer.

Woodland Fox Retreat

Why not hide away at Woodland Fox? Fall is the best season to get away at our peaceful 20 acres just 3 miles off hwy 63. Guest suite is ideal for multiple guests with 4 beds & 2 full baths. To offset “no cleaning fee” $10 per guest per night is added for 4th guest and more. In any case, you’ll have the entire lower-level to yourselves —-to enjoy the comforts of home. Sleep deep with comfy covers—oh, so clean—breakfast ingredients are supplied in fridge. NO Cleaning fee!

New Relaxing 3 bdm house in Quiet Small Town

The fully furnished newly construted in 2025 house provides a quiet & charming space to unwind & relax after a busy day of work or play. Featuring an open-concept layout providing guests the ability to cook a meal & have conversations with others in the adjoining living room. Located in town are 3 restaurants, Casey's & Dollar General. Amish Community is a short drive of 14 miles Mark Twain Lake 32 miles Moberly 12 miles Centralia 22 miles Columbia 45 miles Hannibal 55

Home away from home Loft "B"

We welcome you into this beautiful, spacious loft with a gorgeous kitchen. This loft is a huge 1 bedroom guest suite that is able to sleep 4. It offers a king bed and a trundle bed that includes 2 twin beds. You will also find a rooftop deck that gives fantastic views of downtown Moberly. This loft has all the comforts of home. Across the hall from this loft, you will find our other loft that has 2 bedrooms and sleeps 6. If you have a large group ask about both.

Rissa's Rustic Retreat

We are a Guest House/Mother In Law Suite built in 2023. Situated in a quaint rural town, that is family friendly and situated across from the city park. Well known for fishing, whitetail deer and Turkey hunting, and located just a few miles from Atlanta Conservation Area, Hidden Hollow CA, Long Branch Lake, and many amazing outdoor destinations. We are located just a short drive from a variety of coffee shops, grocery stores and antique shops for your pleasure.

Charming Loft in Downtown Salisbury

You’ll love the NYC studio feel but in central, rural Missouri. Here at the Broadway Lofts we have 400 sq ft of space to host you. Sleep in the comfort of a King sized Sealy mattress, which feels like home away from home. Also, available is a full sized futon for an extra guest (or two if they're small) ;). Walk-in shower with luxury towels and stocked toiletries. Within walking distance of local restaurants, parks, and shopping!