Vacation rentals in Cairo

Gi-Gi’s lake house

Tucked against a wooded background is this peaceful and cozy one bedroom home. Relax on the covered back porch for early morning coffee, spend an evening around the fire pit, or walk to the covered fishing dock to try your hand at fishing. Home has one bedroom with a full sized bed, and two sleeper sofas in the living room. Host family lives in the main house on property. There is ample parking, including space for your boat. Nestled on a lake with public boat ramp but just 15 minutes from town.

Location · Family · Comfort

Moberly's Chic Loft Retreat "A"

This Loft Apartment is the best of all worlds. It is cozy & trendy with plenty of space to stretch your legs! It also boasts fast internet (250Mbs+), an open living area, beautiful kitchen with oversized island for eating or cooking, and huge private bedrooms. A king bed, a queen bed and 2 hideway beds give plenty of sleeping options. If you've got a large group or need more space check out our HUGE 1 bedroom loft right across the hallway! Check us out on FB @TheBiermanSmallEventCenter&Lofts

Location · Family · Outdoor spaces

The Ardmore Lodge & Cabin (Pool/Poker Table & Bar)

The Ardmore Lodge is a 2 building property, nestled within the historic old mining community of Ardmore. The cabin has 2 bedrooms & 1 bathroom. The lodge has an open entertainment space with a half bathroom. You can play pool, cards, darts, poker, or just stream on the big screen. There is also an RV site with water and electric available. The property is located just 5 minutes from Highway 63 on about 3/4 of a mile of gravel. There is ample parking for trailers, boats, and many vehicles.

Family · Location · Condition

3 bed, Fiber, self check-in, laundry, kitchen

Hotel cost, full family house! PACKED with amenities. Only 12 miles from Thomas Hill Power Plant. New construction 3BR/1BA apartment with 1 Gig fiber internet. King bed in master, queen beds in two rooms—each with closets. Fully stocked with towels, linens & essentials. Kitchen includes air fryer, Crockpot, Keurig, coffee maker, microwave & full fridge w/ ice maker. LG washer (15-min wash) & dryer. 1-car garage, covered porch & patio, smart keypad entry, charging outlets, couch & recliner.

Comfort · Access · Long stay

Lost Cousins Loft - A Handcrafted Downtown Retreat

Step into a piece of history in this renovated one-of-a-kind retreat blending character, comfort, and artisanal charm. Countless hours of detailed craftsmanship, custom woodwork, and a deep respect for authenticity create an atmosphere with warmth and soul that cannot be manufactured. Perfect for a weekend escape, creative reset, or private gathering. Guests also enjoy a rooftop terrace in a heartwarming downtown—steps from a winery, coffee shop, professional live theatre, shopping, and more!

Family · Location · Quiet

Beyond the Pines

Relax and bring the whole family to enjoy this spacious cabin home on 50 acres. Explore the outdoors and fish the 2 stocked ponds or stay in and play a game of pool. Not only does this house have plenty of room to accommodate the entire family, but the outdoor amenities will also be loved by all. Included for you to enjoy is a propane BBQ grill for cookouts and a firepit for those late night smores and quality family time. If you are looking to get away this property will not disappoint.

Location · Family · Checkout

New Relaxing 3 bdm house in Quiet Small Town

The fully furnished newly constructed in 2025 house provides a quiet & charming space to unwind & relax after a busy day of work or play. Featuring an open-concept layout providing guests the ability to cook a meal & have conversations with others in the adjoining living room. Located in town are 3 restaurants, Casey's & Dollar General. Amish Community is a short drive of 14 miles Mark Twain Lake 32 miles Moberly 12 miles Centralia 22 miles Columbia 45 miles Hannibal 55

Family · Value · Sleep quality

Briggs Convenience Haven

Newly updated 3-bedroom, 2-bath home in Macon Perfect for families, groups, or extended stays Sleeping 3 bedrooms with queen beds Living room with 2 pull-out sofas Amenities High-speed Wi-Fi Central AC Washer & dryer Location Minutes from Walmart Close to grocery stores, shopping, and restaurants Enjoy a clean, comfortable stay with flexible sleeping options and easy access to everything Macon has to offer. We look forward to hosting you.

Family · Location · Cleanliness

The Scott house in the country.

This cute house is on a working alternative farm that raises grass-fed beef and lamb. If you want to get away from the busy life, come sit on the porch and watch the sunset. A state park is close for kayaking and canoeing. There are some very nice restaurants and wineries close by or you can cook in the large kitchen. There are some great biking trails and horse back riding in the conservation area that's 2 miles away.

Family · Value · Wifi

O's Cozy Cabin at Shelbina Lake

Enjoy the Shelbina Lake with a little extra space! Our cabin offers a place for families and friends to stay without needing a camper and wanting the comforts of a home. Whether planning to hunt and fish, golf, or simply enjoy the lake, this is a prime location here in Shelby County, Missouri! We have a basketball and tennis/pickleball rackets to use as we are directly across the street from the courts.

Location · Family · Pets

Quiet and Relaxing Lake Retreat with Boat Dock

Forget your worries in this peaceful and spacious water front house. Enjoy the beautiful views of Thomas Hill Lake outside the back door. This is the perfect couples retreat or family getaway! Even a great place for hunters & fishermen. Private boat dock with three boat slips and swimming area. Thomas Hill is home to excellent fishing year round.

Value · Location · Cleanliness

Highway BB Pit Stop

Experience the excitement of motocross racing on a weekend with events or choose to relax and enjoy the quiet country setting not to far away from town. This unique tiny home offers the necessities for a night's stay or longer.

Location · Comfort · Hospitality