Guesthouse vacation rentals in Oconee County

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Top-rated guesthouse rentals in Oconee County

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Top guest favorite

Guesthouse in Six Mile

4.96 out of 5 average rating, 163 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Guest favorite

Guesthouse in Lavonia

4.88 out of 5 average rating, 24 reviews

Secluded Lake-House Get-Away: Sleeps 6

Escape to this spacious and cozy lakeside retreat on beautiful Lake Hartwell. Enjoy a 2 BR, 1 Bath open floorplan, fully equipped kitchen, Wi-Fi, Blackstone grill, and a boat dock in this tranquil cove. Relax in a hammock on the outdoor patios. A boat ramp is less than a mile away, ideal for boating or competition fishing. Explore the beautiful North Georgia foothills with hiking trails and waterfalls a short distance away. Whether for a short getaway or a longer stay, we cater to your needs.

Top guest favorite

Guesthouse in Seneca

5 out of 5 average rating, 40 reviews

Hartwell Hideway

Escape to this cozy 1-bedroom, 1-bath apartment perched above a private garage on Lake Hartwell. It's just 15 minutes from Clemson University and quaint downtown Seneca. With a full kitchen, cozy living space, on-site parking, keyless entry, and owners nearby, you’ll have everything you need for a relaxing visit. ✔ New build 2024 ✔ Boat access 5 minutes away ✔ Hiking & waterfalls nearby Whether you're here for a Clemson game, a lake adventure, or a quiet getaway, this is the perfect home base.

Top guest favorite

Guesthouse in Lavonia

5 out of 5 average rating, 64 reviews

High Hope Hideaway - Pool is Open!

Settle into northern Georgia’s High Hope Hideaway for a deep slice of peace and country tranquility. End your work day or kick off your long weekend with a cooling dip in the pool, just steps away from this poolside studio. Enjoy additional outdoor amenities including a gas fire pit, grill, and outdoor dining space. The close proximity to I-85, Atlanta, Greenville, SC; Helen, GA; Lake Hartwell; and Tugaloo State Park make High Hope Hideaway perfect for business travel or a leisurely escape.

Top guest favorite

Guesthouse in Mountain Rest

5 out of 5 average rating, 54 reviews

Coltsfoot Cottage

Come enjoy the South Carolina mountains of Oconee County. Coltsfoot Cottage, located at Coltsfoot Farm, is tucked away on a small horse farm in the quaint community of Mountain Rest, we are seated at just over 1800 feet of elevation within a mile and a half from the sparkling Chattooga River. Highlands, NC, Clayton, GA and Walhalla, SC are just a short drive of 30 minutes (or less) from this unique property. Relax in beautiful mountain scenery and see astonishing sunsets at Coltsfoot Cottage.

Guest favorite

Guesthouse in Westminster

4.85 out of 5 average rating, 34 reviews

Country Guest House

Experience a peaceful stay in a cabin /guest house surrounded by old oaks and pines. Off the beatin path but only 3 miles from restaurants and shopping. Lovely deck for sitting and watching the deer. Fire pit for evening fires and roasting marshmallows. A gravel road leads up to the main house and the guest house is behind the main house with convenient parking and easy access. 1/8th mile from the paved road, so drive slowly to the dead end of the road where it enters the access driveway.

Top guest favorite

Guesthouse in Seneca

5 out of 5 average rating, 8 reviews

The Cottage at Keowee Hollow

Welcome to the Cottage at Keowee Hollow! We are conveniently located minutes from downtown Seneca, 10 miles from Clemson and under an hour from downtown Greenville, Highlands or Cashiers. This cozy 1 bedroom, 1 bath cottage includes a small kitchen, living room and dining area. The back porch offers a small table and chairs where you can start your mornings with a cup of coffee and a beautiful sunrise over Lake Keowee! Cane Creek Landing and South Cove Park are just around the corner.

Top guest favorite

Guesthouse in Mountain Rest

5 out of 5 average rating, 105 reviews

The Guest House By The River

Our Guest House is a quaint little place perfect for couples getaway. It is located on Chauga River, with a great swimming hole and beach. Perfect location if you are interested in River rafting (Chattooga River rafting is near by). If you enjoy hiking, fishing or just enjoying outdoors this is the place for you. Guest House is located to the right of the main house, but it is private. We would love to have you!! Close to Clemson, Cashiers, Highlands, Chattooga Belle Farms.

Top guest favorite

Guesthouse in Six Mile

5 out of 5 average rating, 19 reviews

Lakeside Haven on Lake Keowee

Relax at this cozy lakefront studio on Lake Keowee with access to kayaks, paddleboards, a dock, fire pit, and pool. Perfect for unwinding or exploring, it's close to state parks with hiking trails and just a short drive to Clemson University-great for football weekends. The studio includes a full kitchen, private bath and in-unit washer/dryer providing all the comforts of home. Whether you're here for adventure or relaxation, this lakeside retreat has everything you need.

Top guest favorite

Guesthouse in Toccoa

5 out of 5 average rating, 204 reviews

Toccoa Guesthouse.

The main home was built in 1905. The Guesthouse was designed as a true ‘in-law’ suite and was constructed in 2010. We're in the historic downtown Toccoa neighborhood where folks still sit on their front porches and greet others as they amble by on the sidewalks. You are welcome to use the rear porch and breezeway during your visit with us. You’ll find the property convenient, quiet and private with the advertised essential amenities available to make your visit pleasurable.

Top guest favorite

Guesthouse in Toccoa

4.99 out of 5 average rating, 151 reviews

Cozy Rustic Lakefront Cabin

“on the edge” is a small, cozy, rustic, lakefront cabin with easy walk to a private dock on Lake Hartwell. Great for fishing and swimming. Public boat ramp 2 miles. Living/dining area, two bedrooms. Relax on the large porch with swing and rocking chairs or enjoy fire pit area. No kitchen but includes microwave, full fridge, toaster, Keurig, coffee maker and gas grill. Perfect getaway but also near charming downtown Toccoa, Toccoa Falls, Currahee Mountain, hiking…..

Guest favorite

Guesthouse in Salem

4.89 out of 5 average rating, 315 reviews

Mountain Edge Loft

Private loft apartment on 25 wooded acres, sits separate from main farm house. Private deck overlooking the woods. Everything you need for a cozy stay. Located on the edge of the Blue Ridge Escarpment with lakes Jocassee and Keowee just a few miles away. Numerous state parks, hiking, biking , waterfalls and kayaking or just peace and quiet. We are a sustainable homestead with an organic garden, chickens ,quail, dogs and cats. Our water comes from a natural spring.