Private suite vacation rentals in South Carolina

Find and book unique private suite rentals on Airbnb

Top-rated private suite rentals in South Carolina

Guests agree: these private suite rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guest suite in Columbia

4.91 out of 5 average rating, 247 reviews

Comfy & Private Left Half of a Duplex

Listing is a private and cozy half of a duplex. Guests will have access to a private entrance and parking in a quiet neighborhood. The bathroom has a shower/tub provided with towels, shampoo/conditioner, lotion, soap. One bedroom has queen bed, walk-in closet, and TV. Kitchenette has a sofa lounger, microwave, mini fridge, TV, coffee maker (single cup/round pad inserts), dishes. *1 mile from Saluda Shoals park and Lake Murray. *4 miles from Columbian Mall - tons of shopping and restaurants .

Nov 5 – 12

$75 per night

Guest favorite

Guest suite in Charleston

4.94 out of 5 average rating, 948 reviews

Three-room suite with private entrance

Cozy three-room suite, for 2 guests, attached to my home, with keyless entry on James Island situated halfway between Folly Beach and Charleston. Easy driving distance, about 4 miles, to both. Close to James Island County Park, restaurants and other amenities. Parking available. Handicap Accessible. Dog Friendly (2 dog maximum). No cats. Includes one spacious bedroom, sitting room and private bath. Coffee, snacks and drinks provided. Dedicated to making all guests feel welcome and comfortable.

Aug 6 – 13

$120 per night

Guest favorite

Guest suite in Lexington

4.98 out of 5 average rating, 120 reviews

Quiet and secluded, with a lovely view

Whether you're here for an extended stay with work, visiting family, or taking a much needed break, you'll enjoy this quiet, comfortable retreat. Nestled on a pretty 2-acre lot with big trees and a beautiful view, you'll feel like you're in the middle of the country, when you're actually only a short distance to I-20 and I-26. Easy access to downtown Columbia and Lexington, Williams Brice Stadium, Lake Murray, area hospitals, and restaurants. Congaree National Park is a 35 minute drive away.

Oct 9 – 16

$80 per night

Guest favorite

Guest suite in Charleston

4.97 out of 5 average rating, 895 reviews

Lisa's Suite Serenity ~ no cleaning fee~

A safe place to land between downtown Charleston and Folly Beach on James Island. This charming attached guest suite is located in an eclectic neighborhood amid lots of oak trees and foliage. A private, tranquil place to re-center and relax in between exploring our beautiful city and beaches. I live adjacent and care for this safe, fragrance free cleaned retreat and look forward to welcoming you to the Lowcountry .. providing your private home away from home for wonderful memories.

Oct 27 – Nov 3

$106 per night

Guest favorite

Guest suite in Charleston

4.99 out of 5 average rating, 705 reviews

Private Riverland Loft

Listed as number 5 out of the TOP 15 BEST Airbnb’s in Charleston County!! Close to DOWNTOWN CHARLESTON, arts, culture, restaurants, dining, parks. Private room over garage of my home w/ a SEPARATE entrance. Large rm with a sitting area, KING size Bed and a full bath. Keurig coffee maker, microwave and refrigerator with a freezer provided. In the historic Riverland Terrace neighborhood. A short Uber ride to downtown Charleston ( less than 15 minutes ) and about 15 min to Folly Beach.

Nov 12 – 19

$99 per night

Guest favorite

Guest suite in Hilton Head Island

4.94 out of 5 average rating, 275 reviews

LOCATION! Harbour, Dining, Shops, Beach-1.4 mile

Location .. Location .. Location !!! Private guest suite with independent entrance from outside, total privacy, and complete amenities, queen bed and full bath (no kitchen). Just step outside - great water-front restaurants with live music, weekly fireworks during summer, bars, shops, outdoor pool and BBQ. Supermarkets and more restaurants in 10 minutes walking. Free shuttle from April till September, beach only 1.4 miles. Great golfing, biking, tennis, fishing and water sports.

Aug 19 – 26

$118 per night

Guest favorite

Guest suite in Mount Pleasant

4.87 out of 5 average rating, 393 reviews

Peaceful Studio Apartment/ Mt. Pleasant SC-

Bright studio in a beautiful safe neighborhood. This space is very comfortable for 2 people. 1 comfy queen bed. Private entrance with driveway parking for one car right in front. Wi-Fi, Roku TV with YouTube TV added. A Kitchenette and a large private full bathroom with a walk in shower. Only 3 miles to Sullivan's Island, 4 miles to Isle of Palms and 7 miles to downtown Charleston. No Pets allowed. Check in time is 2pm and check out time is 11am. STR Permit 230313 MP BL #2016474

Jul 21 – 28

$95 per night

Guest favorite

Guest suite in Ehrhardt

4.95 out of 5 average rating, 160 reviews

Lazy Dog Acres Bridal Suite!

Relax by one of the 2 ponds with water features or on the patio. Take a walk around the pond with Isaac or Isabella (Great Danes)as your guide on our 13 acres. Sorry no pets allowed! There is a a micro, fridge & coffee mkr in ur suite. Cook your meal in our shared kitchen. All linens are sanitized w/ high temp sanitizing wash. You have your own private entrance so come and go as you please! Airbnb designated parking. I live on the 2nd floor should u need assistance !

Jul 3 – 10

$117 per night

Guest favorite

Guest suite in Chapin

4.98 out of 5 average rating, 456 reviews

LAKE FRONT SWEET - Dog Friendly

In Chapin on beautiful Lake Murray near Dreher Island State Park. Enjoy the view from the patio, relax on our dock, or float in the lake! There's room for your boat and trailer. Lower level of the house is all yours- incl. bedrm, bathrm, living rm & patio. Kitchenette-No stove, but there's a small kitchen sink, gas grill, full size fridge, microwave, toaster, coffee maker & dishes. We provide linens, coffee, cream, sugar. Dog friendly -1 dog if you agree to our rules.

Dec 10 – 17

$108 per night

Guest favorite

Guest suite in Conway

4.97 out of 5 average rating, 126 reviews

Eclectic Home Near CCU - Private Guest Suite

This 100 year-old home is cozy, with modern rustic vibe. A homey space to spend time in if you want to just hang out and relax. We're only 15 minutes to the beach, 20 minutes to downtown Myrtle, 12 minutes to Coastal Carolina University, 15 minutes to the quaint Downtown Conway. A great location outside of Myrtle Beach with lots of birds and wild animals where you can escape from the hustle and bustle of the city streets and traffic after a long day.

Jul 29 – Aug 5

$85 per night

Guest favorite

Guest suite in Charleston

4.9 out of 5 average rating, 184 reviews

Surfer's Studio! Clean Tiny Apt 2 Miles from Beach

Modern, funky studio apartment located between Folly Beach and historic downtown Charleston. A private entrance & deck overlooking the neighborhood pond is perfect for your morning coffee or a sunset cocktail. Inside is a clean and quiet living space. The ocean, sand, surfers, and dolphins are just 2 miles away, where you can also find great restaurants, shops, music, and the Folly Beach pier. Perfect for couples or a solo traveler.

Sep 11 – 18

$111 per night

Guest favorite

Guest suite in Clinton

4.99 out of 5 average rating, 196 reviews

College View Cottage & Saltwater Pool

Spacious Private Apartment in Lovely Home. You will enjoy the entire lower level of the main house (apprx. 876 sq. ft.) that has a separate, private entrance. Just a block from the campus of Presbyterian College in a quiet, safe neighborhood. My home is also steps from the campus of the Thornwell Home for Children and Thornwell's Lush Acres Farm.

Nov 22 – 29

$89 per night