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Guesthouse vacation rentals in Santo Domingo

Find and book unique guesthouse rentals on Airbnb

Quick stats about guesthouse rentals in Santo Domingo

  • Total vacation rentals

    Explore 70 vacation rentals in Santo Domingo

  • Nightly prices starting at

    Santo Domingo vacation rentals start at $10 per night before taxes and fees

  • Verified guest reviews

    Over 1,270 verified reviews to help you choose

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Santo Domingo vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santo Domingo rentals

Top-rated guesthouse rentals in Santo Domingo

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A single-story studio is presented with a warm orange exterior and two front windows, framed by black metal bars. A gated fence and small grassy area enhance the inviting entrance, while a paved driveway provides access to the space.
Guesthouse in El Millón
4.95 out of 5 average rating, 40 reviews

Private Cozy Apartment Studio

One bedroom studio, centrally located in the heart of El Millón, Santo Domingo, where comfort, convenience, and warm space offers the intimate feel of a family home, featuring: A private entrance for your complete privacy. Dedicated parking for your convenience and peace of mind. Whether you're visiting for leisure or business, our studio is thoughtfully designed to meet your needs. Remote workers will appreciate the high-speed internet, ensuring uninterrupted connectivity throughout your stay.

Guest favorite
A spacious room features a full bed with crisp white linens, flanked by two bedside lamps. Decorative artwork is displayed on the walls, while a wooden desk and a chair are positioned adjacent to the bed. The original hydraulic tile floor adds character to the space.
Guesthouse in Ciudad Universitaria
4.93 out of 5 average rating, 27 reviews

Centrally located and unique colonial-style studio

Unique space in a 1930s house, with rustic-industrial elements. Elegant room with original hydraulic floor. Large patio with perimeter fence and electric gate. Centrally located, less than 3 kilometers from the Colonial Zone, 2.5 kilometers from the Central Polygon. Hospital, Laundry, Pharmacy, Malecon 1-2 blocks away. 500-600 meters from 2 subway stations, close to museums and restaurants. Updated technology. Smart speaker. Wi-Fi. TV with YouTube, Netflix, Prime Video. Double bed (full size).

Guest favorite
Guesthouse in Santo Domingo
5 out of 5 average rating, 6 reviews

VillaMella Oasis 2bedroom2bathroom Patio Hot Water

Welcome to your Oasis in Villa Mella. Relax in comfort and luxury with a second-floor-level, 2 queen beds, 2 private baths, and a fold-out sofa. Enjoy A/C, hot water, fast WIFI, and 3 Roku TVs with Netflix. Secure smart lock entry and 24/7 on-site staff that will ensure peace of mind. Just a 5-minute walk from the Gregorio Gilbert Metro station. Bring the whole family to this great place with lots of room for fun. Need a driver? We've got you covered. Let us melt your stress away! Book now!

Superhost
A cozy bedroom is highlighted by a white bed with a bright yellow pillow. A small vase holds cheerful orange flowers, adding a touch of color to the space. Rich wooden cabinetry can be seen in the background, contributing to the room's inviting atmosphere.
Guesthouse in Santo Domingo Este
4.83 out of 5 average rating, 46 reviews

Cozy 2 BR with BBQ

This 2 bedroom apartment with BBQ private area is truly bright and cozy . It takes 25 minutes to arrive from the airport. The spacious master bedroom has a queen size bed and the very bright single room have two twins bed. You have discount with our car rental services with airport pick-up. The neighborhood is very safe, is private with access control and very clean, there are many restaurants nearby many bars, gyms, movie theaters, shopping malls . The neighbours are lovely and quiet.

Superhost
Guesthouse in Santo Domingo Este
4.67 out of 5 average rating, 30 reviews

Nido del patio, 40 min to Bocachica beach 5 center

You will have the entire apartment just for you. Enjoy the tranquility that the area offers, an ideal place to rest and work, and a strategic point to travel to places of interest You are responsible for cleaning the accommodation during your stay. It is delivered clean. If you need it, you can request cleaning service at an additional charge. The patio is rarely shared. Usually, only you will enjoy the patio. The host is in charge of cleaning the patio area.

Top guest favorite
A bright living area features a decorative wall with a warm brick design, complemented by a wooden ceiling. A television is positioned on a simple black console, while a round dining table is adorned with a vase of elegant flowers, adding a touch of nature.
Guesthouse in El Millón
4.96 out of 5 average rating, 82 reviews

Cozy apartment for work / holidays.

Comfortable apartment, on second level, with private parking, ideal for holiday trips, congresses, jobs and others. Close to shopping centers, Recreational park, clinics, universities; 25 minutes from the colonial area. Located in downtown area of the city, in the urbanization El Millón del Distrito Nacional. Peaceful, residential place with access to the main roads of the city.

Top guest favorite
The exterior of the property features a modern one-story structure with a terracotta roof. Steps lead down to a clear pool, surrounded by well-manicured hedges and lush greenery. Soft lighting highlights the entrance, offering a welcoming presence during twilight.
Guesthouse in Santo Domingo
5 out of 5 average rating, 16 reviews

Near U.S. Embassy – Visa Appointments – Guest House – Pool

You no longer need to leave the city to feel in the mountains, this is an independent 1 bed 1 bath Guest House in a closed residence with a 10-meter pool shared with the Hosts. With a Coway potable water filter. Supermarkets, Cinema, Shops, and Hair Salon nearby. A few minutes from the center of Santo Domingo and 1.8 km from the American Embassy.

Top guest favorite
Guesthouse in Las Caobas
4.91 out of 5 average rating, 22 reviews

Your little corner of peace in SDO

Kick back and relax in this calm, stylish space. “Tu rinconcito de Paz” is an oasis in the middle of the city rush, take some fresh air in our outdoor Gazebo area, enjoy the privacy and security of our small but cozy house. Commercial centers as Carrefour and numerous restaurants are located at 8 minutes away from our spot.

Guest favorite
Guesthouse in Santo Domingo
4.93 out of 5 average rating, 15 reviews

U.S. Embassy Suites

Have fun with the whole family at this stylish place while taking it easy at a unique and tranquil getaway. Perfect while on the go or for appointments at the U.S. embassy. Guesthouse comes included with access to an olympic style pool, outdoor patio and barbecue grill. Great for evening get togethers and celebrations.

Guest favorite
A lush backyard features a swimming pool surrounded by greenery and decorative elements. A barbecue grill is positioned on a stone patio, while comfortable seating arrangements invite relaxation. Colorful plants and well-maintained flower beds enhance the serene outdoor setting.
Guesthouse in Residencial Alameda
4.87 out of 5 average rating, 85 reviews

Oasis privado con piscina en residencial tranquilo

Private pool just for you. Independent attached house with large garden and terrace ideal to enjoy as a family. Located in a quiet and safe residential area, close to everything. Air-conditioned and comfortable spaces. Perfect for getaways, weekends and a break in the city.

Superhost
Guesthouse in Los Frailes
4.83 out of 5 average rating, 6 reviews

Mamuchi House, Zona Franca San Isidro, base aérea

2 bedroom apartment with A/C, private bathroom, 3rd floor. Ideal for you if you are looking for a comfortable space near the Free Trade Zone of San Isidro and Air Base, rest in a family atmosphere. Base rate valid for 2 people, one room.

Guest favorite
A spacious bed is positioned against a wooden headboard, featuring decorative pillows in shades of red and neutral tones. Nightstands with lamps are placed on either side, with a decorative throw lying across the foot of the bed. Soft lighting creates a cozy ambiance.
Guesthouse in Ensanche La Fé
4.87 out of 5 average rating, 62 reviews

Your cozy little guest house

Enjoy your stay! Comfortable and pleasant guest house on the ground floor (no stairs, no elevators) cool patio, in the city center, near the Quisquella Stadium, Plaza de la Salud, shopping malls, etc.

Popular amenities for Santo Domingo guesthouse rentals

When is the best time to visit Santo Domingo?

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