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Vacation rentals in Santa Isabel District

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in La Guaira
5 out of 5 average rating, 7 reviews

Apt near sea+Parking+TV+AC+Kitchen+WiFi@La Guaira

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐 Wifi 📺 TV 🍳 Cocina ❄️ A/C 🌊 Cercano a la playa 🚗 Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque
4.87 out of 5 average rating, 92 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

Home in Playa Chiquita
5 out of 5 average rating, 7 reviews

Caribbean Jungle Beach House

Secluded loft beach house on 7 hectares of jungle with pristine beach. Enjoy the peaceful tranquility of coconut palm tree covered golden sand beach with shallow warm water great for swimming and body surfing. Lounge chairs, barbecue, kayaks, snorkel masks, boogie boards, hammocks and a fire pit for beach bonfires under the starry night sky all available. Great for families, couples or groups of friends. Delicious Panamanian food made to order on site. Tent camping (glamping) also available.

Guest favorite
Home in La Guaira
4.8 out of 5 average rating, 35 reviews

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)

Hermosa Casa de Playa, frente al mar caribe, para descansar y relajarse al 100%. La Casa cuenta con una ubicación privilegiada, mantiene 4 habitaciones (una de ellas cuenta con una mampara para dividir de la sala y ampliar esa área en caso que se desee), sala, comedor, terraza privada, frente a Isla Grande. 4 habitaciones. 3 tienen TV con cable y una TV extra en la sala. Todas con con Aire Acondicionado. Cuenta con 2 baños completos. Cocina equipada y lista para disfrutar y Wifi

An aerial view shows a property situated by the water, featuring red-roofed cottages and a grassy yard. Kayaks are visible in the water, along with seating areas under palm trees. A smooth pathway leads down to the water's edge, offering direct access for guests.
Home in Viento Frío
5 out of 5 average rating, 8 reviews

Casa Canalú

Enjoy the sounds of the sea when you stay at this unique place. The sea in front of the property is like a natural pool. The property is located six meters from the sea so you can always enjoy the sea breeze from a hammock. Those who like to cook will have a fully equipped kitchen. The 3 comfortable rooms, which are separated from each other, have air conditioning, fans and WiFi. Parking for several cars. Pedal boat, Kayak, Canoe

Home in Palenque
4.5 out of 5 average rating, 4 reviews

Palenque Beach House · Pool & BBQ

Escape to this stunning beachfront home in Palenque! With 5 spacious bedrooms and 16 beds, it’s perfect for families, retreats, or group getaways. Enjoy a private pool, BBQ area, and direct beach access. The two-story layout offers ocean views, a full kitchen, and open living spaces for comfort and connection. Relax, recharge, and make unforgettable memories by the sea in this tropical gem!

Guest favorite
The two-story house is positioned just steps from the water's edge, surrounded by lush greenery and palm trees. A spacious terrace extends from the upper floor, providing a view of the serene landscape. The natural stone shoreline complements the tranquil setting.
Apartment in Colón
4.93 out of 5 average rating, 103 reviews

KasaKai garden floor - amazing views over the sea

Caribbean downstairs apartment with amazing sea view. Surrounded by wildlife. This property has a private access to the Caribbean Sea. The house is situated over a 2 miles long reef. Amazing snorkeling, there are many naturals pools into the reef where you can snorkel. Ideal for kids! There is a jungle behind the house which makes that you will hear the monkey from the house.

Guest favorite
An aerial view showcases the property nestled between two natural beaches, surrounded by lush greenery. Calm waters and rocky formations are visible nearby, alongside beachside features that highlight the area's tropical environment.
Villa in Palenque
5 out of 5 average rating, 10 reviews

Beach Front House Surrounded by 2 Private Beaches

La propiedad esta rodeada de dos playas naturales. Preserva una selva primaria con múltiples clases de arboles endémicos del área que sirven de alimento a los aulladores, titis, perezosos y muchas aves en especial tucanes que vienen a comer uvitas tropicales. Tenemos un camino interno para observar la selva. Entre Marzo-Mayo y Agosto-Oct se observa la migración de aves.

Chalet in Viento Frío
5 out of 5 average rating, 4 reviews

Spacious seaside villa

Duplex home. Great for events or groups for short stays. Equipped for families on long stays. Beach without sea urchins or stones. Waves and sea breeze on one side; and on the other side, the town center, the park and a century-old church. Village with annual celebrations such as "Race Day". I can give you an offer for 4 people, for a single night or for less.

A welcoming entrance to Casa Guaymar is framed by lush greenery and vibrant plants. The structure features a spacious porch, highlighted by the colorful sign overhead. Large glass doors allow for a view of the inviting interior and surrounding landscape.
Home in Juan Gallego
4.57 out of 5 average rating, 21 reviews

House facing Isla Grande

Discover the Caribbean paradise at Casa Guaymar, an oceanfront house with a pool, bar, hammocks, and a spectacular view of Isla Grande. Perfect for groups of up to 16 people, with spacious spaces, 4 bedrooms with king beds and 8 single mattresses. Experience crossing to the island from the very shore of the house. Ideal to disconnect and enjoy.

A view of the house, set against a backdrop of palm trees, showcases its two-story structure with large windows and a red-tiled roof. The property overlooks a calm lagoon, with a stone pathway leading down to the water's edge.
Home in Palenque
5 out of 5 average rating, 9 reviews

Beach Front Caribbean Paradise at Palenque

Amazing beach front view will make you feel in touch with the ocean and its creation. A perfect place to relax and meditate . Located 2 hours and a half from Panama City is a place to enjoy the beach while listening to the sound of the waves and swim in shallow waters with sand button. You wilo feel the beauty and power of its creator!

Guest favorite
Home in Palenque
4.83 out of 5 average rating, 6 reviews

Casa Palenque Panama

Enjoy a spectacular oceanfront house, ideal for groups and families of up to 14 people. Relax with direct beach views, spacious indoor and outdoor spaces, and all the comforts for an unforgettable stay. Perfect for resting, living and creating unique memories with the sound of the sea in the background. We are pet friendly.

Popular amenities for Santa Isabel District vacation rentals