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House vacation rentals in Santa Cruz

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
An open living space features a light-colored sofa, coffee table, and accent chairs, complemented by an area rug. The dining area includes a table with high-backed chairs, while the kitchen is visible in the background, showcasing a well-lit and functional layout.
Home in Santa Cruz de la Sierra
4.95 out of 5 average rating, 85 reviews

Nice 2 bedroom house, the best rest.

Charming 2-bedroom house, equipped and decorated with timeless style. Located in a quiet and ultra-safe condominium, just 10 minutes from Viru Viru Airport and 30 minutes from downtown. Enjoy the condo's amenities: Swimming pool with slides Supermarket and ATM within walking distance Gym, saunas and jacuzzi to relax Walking circuits and tennis and soccer courts to stay active. Great for: Relaxing away from the hustle and bustle A stop after a flight Families and groups of friends.

Superhost
A tranquil area is featured, showcasing a large, shimmering lagoon with palm trees lining the shore. Colorful, casual seating is visible on the sandy ground, providing spots for relaxation. The clear blue sky is dotted with a few clouds, enhancing the serene environment.
Home in Santa Cruz de la Sierra
4.8 out of 5 average rating, 15 reviews

Davezies House, A Unique Experience, Inland Sea

Discover a unique and surprising place! A house with 2 suites, including an impressive Master Suite. Enjoy spacious and sophisticated spaces in the living room and a fully equipped American kitchen. Relax in the pool or barbecue, perfect for sharing unforgettable moments with family and friends. Air conditioning, LCD TV and WiFi throughout the house, you will have everything you need. Access to incredible facilities: beach, restaurant, tiki bar, children's playground and more.

Superhost
A bright living area is presented with two light-colored sofas adorned with colorful pillows. A wooden coffee table is centered between the sofas, while two stylish chairs are positioned nearby. Large windows allow natural light to fill the space, showcasing indoor plants.
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 4 reviews

Beautiful house, private condominium

Hermosa casa de 320 m² construidos, ubicada en la Av. Milton Parra, esquina prolongación Av. Beni. Ideal para familias, cuenta con 2 dormitorios, una oficina y 1.5 baños. Dispone de un comedor espacioso y confortable, así como una cocina grande y bien equipada. Esta propiedad se encuentra en un condominio privado que ofrece áreas verdes y zonas de entretenimiento, tales como: - Piscina - Gimnasio - Cancha de fútbol de césped sintético - Cancha de baloncesto - Salón de eventos

Guest favorite
A spacious living area features a large white sectional sofa adorned with decorative pillows. A dark coffee table sits at the center, surrounded by a plush area rug. A pendant light hangs above, illuminating the space, while a piece of wall art adds a touch of color.
Home in Santa Cruz de la Sierra
4.97 out of 5 average rating, 30 reviews

Centrally located and spacious house 50 meters from 2nd Ring

One-story house with an unbeatable location and well-lit spaces. It has 4 spacious bedrooms (2 en suite). Fully furnished and very well decorated to make you feel at home. Located 50 meters from the 2nd Ring between Av. Alemana and Beni avenues, a safe and easily accessible residential area. Assisted by supermarkets, restaurants, such as the traditional “Casa del Camba” and others. Spacious social areas, living room, dining room, and barbecue. A fully-equipped kitchen.

Superhost
The two-story house features a terracotta roof and a welcoming entrance. The patio area is paved and includes potted plants. A carport is visible on the right side, providing shelter for vehicles. Surrounding greenery adds a touch of nature to the space.
Home in Santa Cruz de la Sierra
4.92 out of 5 average rating, 13 reviews

Comfortable and safe house SC

The house is very nice, comfortable and safe. Located 12 minutes from historic downtown Santa Cruz. Within walking distance are the Military Engineering School (EMI), the Military Aviation College and the Center cinema. In the surroundings you can find food businesses, pharmacies, mini supermarkets, health centers, urban park, squares and availability of transportation to all latitudes. Excellent location to rest with total peace of mind and security.

Guest favorite
The serene pool area is highlighted by clear blue waters, surrounded by lush palm trees and tropical vegetation. Sunlight reflects off the water's surface, offering a calm and inviting atmosphere for relaxation. The space provides access to nearby facilities and is designed for leisure.
Home in Santa Cruz de la Sierra
4.96 out of 5 average rating, 23 reviews

Condominium house near Fexpocruz for 8

New house, cozy, ideal for a large family, one floor with four bedrooms and four bathrooms, garden, gallery and barbecue to enjoy the outdoors. Enjoy the security of a beautiful condominium with multi-functional courts, a children's playground, a large swimming pool, barbecues with a cabin, a micro market, and private streets with 24-hour security. Located very close to Fexpocruz, a few minutes from downtown and Equipetrol.

Top guest favorite
A spacious bed with a blue upholstered headboard is positioned in the foreground. In the background, a kitchenette features basic cooking appliances, and a small dining table with two chairs is visible. Light enters through a nearby window, illuminating the room.
Home in Santa Cruz de la Sierra
4.98 out of 5 average rating, 44 reviews

Comfortable studio apartment in the center

PLEASE read the listing carefully before booking. Spacious, comfortable and centrally located, newly renovated studio for a maximum of two people. It has air conditioning, a 32” smart TV, a kitchen equipped with the basics for cooking not very elaborate meals, a private bathroom and WiFi. Ideal for short stays for leisure or business trips. Many buses pass by the house's door, making it easy for you to get around the city

Guest favorite
A small house with a rustic exterior is situated near a calm, reflective artificial lake. Surrounded by trees and natural vegetation, the house features a rounded window and a clay-tiled roof, creating a tranquil and serene environment.
Home in Samaipata
5 out of 5 average rating, 15 reviews

"Casita Laguna" Fully equipped small house

Small 20 square meters house with queen bed, situated on the edge of a 20 meters across artificial lake, this house has its own kitchenette with stove, electric kettle and fridge, it has a private bathroom with hot water. This house has a front and back patio equipped with chairs and coffee tables. All this is part of Casa Samai Boutique, a small hotel situated on a 2.5 hectares peace of paradise.

Guest favorite
The image captures a relaxing jacuzzi surrounded by lush greenery. Sunlight filters through the trees, illuminating the bubbling water. A tranquil atmosphere is created by the natural setting, offering a peaceful retreat for guests.
Home in Buena Vista
4.88 out of 5 average rating, 8 reviews

Capibara House

Bienvenidos a tu Refugio en Buena Vista! Una encantadora casa céntrica a solo 3 cuadras de la plaza, con una vista impresionante al Parque Amboró. Relájate en el hidromasaje, descansa en la suite con baño privado o en el acogedor cuarto de 2 camas. También cuenta con la elegante sala con sofá cama, cocina equipada y parrillero hacen de este hogar único tu escapada perfecta.

Guest favorite
A serene outdoor area features a swing adorned with a fabric covering, surrounded by lush greenery. Decorative stone paths lead through a well-maintained lawn, complemented by minimalist landscaping elements, including potted plants and a grilling area built into the wall.
Home in Santa Cruz de la Sierra
4.94 out of 5 average rating, 17 reviews

Minimalista y vintage

Escápate a esta casa minimalista con toque vintage rodeada de naturaleza, dentro de un complejo completo con piscina, cancha polideportiva, tenis y sauna. Perfecto para disfrutar un fin de semana inolvidable en familia a solo 1 0 minutos del aeropuerto y 20 min de la ciudad. Cuenta con parrillero y jacuzzi dentro de la casa y totalmente automatizada

Guest favorite
A villa is shown with a tiled roof and a spacious outdoor patio. Lush greenery surrounds the area, complemented by palm trees. Glass doors provide natural light and an inviting connection to the exterior. Air conditioning units are visible on the exterior walls.
Home in Santa Cruz de la Sierra
4.86 out of 5 average rating, 14 reviews

House

This House is just 5 minutes from Viru Viru airport, and 10 minutes from the city center. It is 12 minutes from the Hotel los Tajibos. This Village has private access, Electric Gate, BBQ Steakhouse, Pool private, Wifi, Full Kitchen, air condition in All room and living room, Very much like being at home. You can receive visits 24 hours a day.

Guest favorite
A wooden-paneled hallway leads to a cozy sleeping area with a spacious bed visible in the background. A small round table with black stools occupies the foreground, accompanied by a decorative plant. A side table with ornamental items is positioned along the wall.
Home in Santa Cruz de la Sierra
4.91 out of 5 average rating, 131 reviews

Attached Apartment

Welcome to our cozy apartment in one of the most beautiful and secure areas in the downtown! Just 6 blocks away from Plaza 24 de Septiembre, our historic neighborhood offers a unique experience. Although the entrance is shared with the main house, we ensure your privacy and comfort. Enjoy your stay in our wonderful city!

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