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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The living area features a comfortable couch positioned near a large window, allowing natural light to fill the space. A flat-screen television is mounted on a wood-paneled wall, and a small round table is visible nearby. The view showcases the city skyline and nearby greenery.
Condo in Santa Cruz de la Sierra
5 out of 5 average rating, 22 reviews

Luxury, comfort, ideal location

Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Guest favorite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Apartment in Santa Cruz de la Sierra
4.9 out of 5 average rating, 126 reviews

Studio 518 - Luxury near Everything

Acceso automático, 2 Aires Acondicionados, Lavadora, Cocina, Sofa y TV perfecto para trabajar todo el día con una vista verde de un 8 piso desde el barrio más cotizado de la ciudad, Equipetrol. Si te aburres puedes usar la piscina sin costo, áreas sociales, asado BBQ. Si te aburres más estarás a 2 minutos de Supermercados, Farmacias a cuadras de la principal de Equipetrol con Restaurantes renombrados, a 5 min de la Plaza Central o a 5 min del shopping más grande de Bolivia, Ventura Mall.

Top guest favorite
An expansive rooftop pool is illuminated by soft lighting, reflecting the city skyline at night. Lounge chairs are neatly arranged along the pool's edge, and the sleek wooden deck complements the modern aesthetic of the space.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 108 reviews

Luxurious and modern apartment. Equipetrol Sky Elite

This luxurious studio is located in the Equipetrol neighborhood, Sky Elite Building, one block from the Los Tajibos Hotel; it represents the perfect combination of exclusivity and first-class amenities in the city of Santa Cruz de la Sierra, surrounded by restaurants, shops, cafes, pharmacies and supermarkets. The building offers more than 3,000 square meters of social areas including a modern gym, extensive swimming pool, barbecue, coworking, private movie theater, sauna and whirlpool.

Top guest favorite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 35 reviews

Green Tower 26th Floor, Luxury, Panoramic Views

Enjoy your stay in the highest Airbnb in Santa Cruz, and in the best building in the city. In the facilities you can enjoy a swimming pool, steam sauna, spectacular views from the 26th floor towards the beautiful Manzana 40 building, the nature of the ecological cordon and the urubo. A few steps from supermarket, restaurants, mall, business center, banks, spa. The tallest and most beautiful restaurants in Santa Cruz, Cielo Skay Bar and Jardin de Asia, are in the same building.

Top guest favorite
A modern interior is presented, featuring a cozy seating area with a dark sofa, complemented by a circular coffee table. A wooden divider offers separation from the sleeping area, where a spacious bed with neutral bedding is visible. Natural light fills the space from the nearby window.
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 31 reviews

SkyLuxia New Equipetrol Apartment - Safe & Luxurious

Enjoy and relax in this new, quiet and elegant space for two people. Located in Equipetrol, the best area of Santa Cruz, close to restaurants and shopping centers. It offers comfort, convenience and safety. You'll find: WiFi, 55” Smart TV, Cable TV, Air Conditioning, Washer + Dryer. ✔ Large swimming pool and sauna ✔ Gym ✔ Meeting room ✔ 24/7 Reception Fully equipped with towels, shampoo, conditioner, soap, toilet paper, tea, coffee, sugar, salt and oil.

Top guest favorite
A well-appointed living space features a modern kitchen with wooden cabinetry and stainless steel appliances, including a refrigerator. A cozy seating area with a light gray sofa is arranged beside a spacious bed, while natural light filters through large windows.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 46 reviews

Smart Studio in Equipetrol

Welcome to this great Smart Apartment in the best residential and business area of Equipetrol. You're half a block from Av. San Martin and a short walk from restaurants, shops, bars, and more. The apartment is fully furnished with everything you need for a comfortable stay, including a fully equipped kitchen, air conditioning, Wi-Fi, and a large flat-screen TV. It has a swimming pool, barbecue, co-work rooms and washing machines on the terrace and common areas

Top guest favorite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 17 reviews

GREEN TOWER SC Luxury Apartment 22nd Floor

Luxury Suite in Green Tower – Santa Cruz 22nd Floor. Live in the tallest and most exclusive building in the city, on the 22nd floor, with panoramic views of Manzana 40, the ecological cordon and the Urubó. Enjoy world-class cuisine in the same building, at Jardines de Asia, Caudilla, and the impressive Sky bar, plus free access to the pool, sauna, steakhouse and Sport Motion gym. A new apartment! Furnished with high-end pieces, including a large sofa bed.

Top guest favorite
A comfortable living area features a spacious sofa paired with a chair, offering a view of the city through large windows. A modern flat-screen TV is mounted on the wall, and a small plant decorates the table, enhancing the room's inviting ambiance.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 55 reviews

Modern Apt WiFi, AC, Kitchen, Pool, Washer, Parkng

✨ A space designed for your comfort and relaxation. Located in a safe and quiet area, this modern apartment combines style, convenience, and technology to offer you a unique experience. Perfect for business travelers, couples, or small families, this accommodation features high-speed WiFi, air conditioning, and premium entertainment, along with access to a pool, gym, and free parking. 📌 Enjoy an unforgettable stay with all the amenities you deserve!

Guest favorite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Modern Elegance Equipetrol - Perfect Location

Vive una experiencia única en este elegante y moderno departamento ubicado en la mejor zona (Equipetrol). A solo unos pasos del centro comercial más grande del país (Ventura) disfrutarás de un espacio sofisticado, totalmente equipado y con todas las comodidades: Piscina, gimnasio y seguridad 24 h. Perfecto para viajes de trabajo o descanso, el departamento es comodo y acogedor. La ubicación es inmejorable, rodeada de restaurantes, cafés y mucho mas.

Guest favorite
An outdoor terrace features sleek wooden decking, complemented by low seating arrangements and lush greenery. A tranquil water feature runs along one side, reflecting the surrounding cityscape. Modern buildings rise in the background under a clear, blue sky.
Apartment in Santa Cruz de la Sierra
4.95 out of 5 average rating, 44 reviews

Elegant family apartment in Equipetrol

Have fun with the family in this new, central, and stylish accommodation. Beautiful and modern apartment located in the best area of Santa Cruz. Just a few steps away from the city's best restaurants, pharmacies, supermarkets, cafes, nightclubs, and shopping malls. Ideal for families, a group of friends, or two couples. You can have all the comforts of a luxury apartment for a cozy and pleasant stay. The building's common areas are a dream!

Top guest favorite
A spacious bed is positioned against a large window, offering a view of the cityscape. Soft pillows and a neatly arranged blanket enhance the comfort of the sleeping area. A small rug lies on the floor, complementing the modern decor.
Apartment in Santa Cruz de la Sierra
4.88 out of 5 average rating, 133 reviews

Comfortable/modern studio apartment beautiful view 300Mbps

Bienvenidos a la zona más activa de Santa Cruz! El precio ya incluye todas las comisiones no pagarás nada adicional en la app. El apartamento es un monoambiente totalmente equipado, moderno y cómodo. Cuenta con una cama de 2 plazas y un sofá cama además del baño privado, lavadora/secadora, cocina y todos los electrodomésticos necesarios. Internet Wi-Fi, tv cable y NETFLIX. Cerca de supermercados, los mejores restaurantes de la ciudad y malls.

Guest favorite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 119 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Bolivia
  3. Santa Cruz