Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Guest suite in Nogales

4.94 out of 5 average rating, 121 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, sofa, picture window,french doors, electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.Also great for hunters, hikers.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Golf Course, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Guest favorite

A private deck offers relaxing sun loungers with colorful towels, overlooking a hot tub and views of the expansive high desert landscape. The distant mountains create a serene backdrop, complemented by a clear sky with scattered clouds.

Cottage in Patagonia

4.96 out of 5 average rating, 108 reviews

Kestrel Cottage at Birdsong Retreat

Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being. Experience nature's embrace, modern comforts, and endless adventure. >>MORE INFO AT BIRDSONGAZ dot com. Experience the tranquil silence, broken only by the distant howls of coyotes and the soft chirping of crickets. Lose

Top guest favorite

A stone pathway leads through a metal gate, surrounded by lush greenery and low shrubs. A mature tree provides shade, while various plants add color to the landscape, creating a welcoming entry to the outdoor space.

Guest suite in Tubac

4.95 out of 5 average rating, 229 reviews

Private Tubac Retreat under The Milky Way

A tranquil, spacious, and beautiful Casita. Comfortable King bed with a gel memory foam mattress, additional pillows and blankets for your convenience, private bathroom, microwave, small fridge, toaster, coffee maker, and teas and coffee for a quick bite. Private entrance and a small patio with seating area, which leads to the staircase to the roof where you can enjoy the view during the day and the Milky Way at night. Large screen TV with Netflix and Hulu (bring your own passwords), and Wi-Fi.

Guest favorite

Guesthouse in Patagonia

4.93 out of 5 average rating, 46 reviews

Cosy House: One bedroom - great WiFi and RO water

Welcome to Cosy House! Relax and recharge in this well equipped, comfortable home - or work remotely in comfort. Enjoy fast, reliable wifi (rare here) and an in-unit reverse osmosis (RO) water dispenser - also a treat here - in the full kitchen. Other features include a comfy queen size bed, 100% cotton sheets and towels, well-equipped kitchen (including French press coffee maker), and desk Explore photos/captions and additional descriptions for full details, and feel free to ask questions!

Guest favorite

Guest suite in Patagonia

4.95 out of 5 average rating, 111 reviews

Box T Studio

The Studio is a moderate sized living quarters set up purposely for lounging, relaxing, personal entertainment and rest. Set within the compound of a historical property (The Box T Ranch built in 1902), the studio is the perfect home plate for all your Southern Arizona adventures. It includes an amazing king size bed, comfortable furnishings, a 57" Sony TV, mini fridge, microwave, Keurig, 2 person walk in shower and an AC unit. We are within 5 minute walking distance into town. Perfect getaway!

Guest favorite

A vibrant sunset casts a spectrum of purples and oranges across the sky, with silhouetted mountain peaks in the distance. The scene is set against a tranquil landscape dotted with sparse trees, showcasing the natural beauty of the surroundings.

Guesthouse in Elgin

4.96 out of 5 average rating, 239 reviews

Cozy Thunder Mountain Ranch bunkhouse experience

The perfect "getaway" that's still "near" it all! Our stand alone southwestern bunkhouse offers comfortable accommodations in a very unique setting, surrounded by thousands of acres of the Coronado National forest. Located in the desirable Sonoita/Elgin area of Southern Arizona. Near Parker Canyon Lake! From just soaking up the quiet serenity for a day or two, to an adventure filled longer stay, we can help tailor your experience to enjoy the many different things to see and do in the area.

Top guest favorite

Apartment in Tubac

4.99 out of 5 average rating, 201 reviews

Coolest AirBnB in Tubac-Private Unique Free Charge

Located in the historic district of the village; a Tubac icon. Drive for free ... charge with my Level 2 solar while you're here; house is 100%, solar. Private, secure, best location, warm weather, fast Internet, new and comfy bed, complete kitchen, high quality AC, quaint, free easy parking, washer/dryer, walled courtyard with a fountain, walk-in shower, light blocking shades. Eight excellent restaurants within 1 mile. An exceptional value, best price, no deposit or cleaning fees

Top guest favorite

Home in Tubac

5 out of 5 average rating, 120 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favorite

A serene nature scene features a clear stream gently flowing over smooth stones. Lush green grasses and foliage frame the water, creating a peaceful environment. The surrounding area showcases natural textures and colors, suggesting a tranquil retreat for wildlife and bird enthusiasts.

Guesthouse in Patagonia

5 out of 5 average rating, 12 reviews

Bird Lover’s Casita

Modern, renovated 1BR (Queen hybrid mattress), 1bath, open floor plan kitchen - LR, 43" Smart TV. Quiet nature setting, great for bird lovers. Pond with 80ft stream a few steps away. Starlink high speed internet, suitable for remote work. Fully equipped office with 2 monitors, printer, web conf. setup available in sep. building few steps away (extra charge). 1 month or longer preferred. Owner lives across the courtyard. Guest must be comfortable with two dogs roaming around

Top guest favorite

Cottage in Patagonia

4.97 out of 5 average rating, 100 reviews

Country house with spectacular views

Disconnect from your worries in this spacious and serene private space, where you can enjoy natural light, contact with nature and beautiful natural views. It has a fully equipped kitchen, dining room, living room, living room with TV and reclining armchairs, 3 large bedrooms, a game room, laundry room and a beautiful porch where you can rest in the living room or in the outdoor dining room as well as enjoy beautiful sunsets. It also has a kiosk with lighting.

Guest favorite

Guesthouse in Rio Rico

4.87 out of 5 average rating, 348 reviews

Cozy Rio Rico guesthouse with a view

This spacious guesthouse is in an ideal rural setting. Located near the Mexican border, the art community at Tubac, and the old Spanish mission of Tumacacori, there is lots to see and do. (Not to mention many good golf courses.) I am looking forward to your visit! To make your stay both pleasant and sanitary I steam clean floors, sani-wash all linens and towels, and wipe counters, sinks and toilet with sanitizer spray. Rest easy here!

Top guest favorite

A charming guesthouse, surrounded by natural landscaping, features a welcoming door framed by a small porch. Large windows provide views of the outdoors, and a stone pathway leads to the entrance, adding to the inviting atmosphere.

Guesthouse in Patagonia

4.92 out of 5 average rating, 116 reviews

Mesquite Cottage

A guesthouse, nestled in a grove of mesquite trees, located just a block away from the local shops downtown awaits your arrival. A full kitchen, supplied with the basic conveniences, bedroom with queen size bed and twin sofa bed, and bathroom with shower, make this space a perfect fit for a couple or small family. The front living room has a futon couch and smart TV.