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Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.
Guest suite in Nogales
4.94 out of 5 average rating, 136 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, picture window, sofa, french doors,electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.Also great for hunters, hikers.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Golf Course, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Top guest favorite
Guest suite in Patagonia
4.95 out of 5 average rating, 127 reviews

Box T Studio

The Studio is a moderate sized living quarters set up purposely for lounging, relaxing, personal entertainment and rest. Set within the compound of a historical property (The Box T Ranch built in 1902), the studio is the perfect home plate for all your Southern Arizona adventures. It includes an amazing king size bed, comfortable furnishings, a 57" Sony TV, mini fridge, microwave, Keurig, 2 person walk in shower and an AC unit. We are within 5 minute walking distance into town. Perfect getaway!

Top guest favorite
The bedroom features a king-size bed with a light blue quilt and two accent pillows. Soft yellow curtains frame the window, allowing natural light to fill the space. Two bedside lamps with red shades illuminate the room, and a framed artwork hangs above the headboard.
Guest suite in Tubac
4.96 out of 5 average rating, 146 reviews

Tubac Golf Resort Casita

The casita is located between the Golf Course and Tubac village. The casita has a private bedroom and bathroom with outside entrance. The private yard has a covered porch and outdoor kitchen. Inside is a king-size bed, table, chairs, refrigerator, microwave, coffee pot. Amenities include WIFI, local TV, Peacock. Weekly and long stay discounts. Early checkin/late checkout usually available... Please ignore the 13 photos at end. They are for my small house listing in case you are interested.

Guest favorite
A southwestern-style ranch home is nestled on expansive land, surrounded by rolling plains. The structure features a white exterior with traditional architectural elements. Majestic mountains are visible in the distance under a clear sky, enhancing the serene rural landscape.
Home in Elgin
4.94 out of 5 average rating, 158 reviews

Peaceful SW-style ranch home in wine country

Welcome to our southwestern style ranch home in Sonoita/Elgin, Arizona wine country! Our home is 2,600 square feet and sits on 40 acres with unobstructed views of the beautiful Santa Rita Mountains. Our entire home is available for a wine country getaway. With three bedrooms, two full bathrooms with dual vanities, a half bath, an amazing kitchen, dining, two living spaces, and high-speed Internet, our home is ideal for two or three couples, or a family getaway (crib available for use).

Top guest favorite
A round mirror framed in metal reflects a cozy sleeping area featuring a colorful blanket on the spacious bed. The rustic brick wall is enhanced by a small natural wood piece placed below the mirror, adding a touch of texture to the interior.
Tiny home in Elgin
4.97 out of 5 average rating, 122 reviews

Private casita on Thunder Mountain Ranch

It's the perfect "getaway" that's still "near" it all! Our stand alone southwestern fully equipped Casita offers comfortable accommodations in a very unique setting, surrounded by thousands of acres of the Coronado National forest. Located in the desirable Sonoita/Elgin area of Southern Arizona. From just soaking up the quiet serenity for a weekend, to an adventure filled longer stay, we can help tailor your experience to enjoy the many different things to see and do in the area.

Top guest favorite
A refreshing saltwater pool is framed by a spacious deck, lined with comfortable lounge chairs. The surrounding landscape features native plants and offers expansive views of the desert terrain and distant mountains under a dramatic sky.
Cottage in Patagonia
4.97 out of 5 average rating, 119 reviews

Kestrel Cottage at Birdsong Retreat

ATTENTION SUMMER BOOKINGS: Swamp cooler entire cottage and AC wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Cottage priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.

Top guest favorite
A clear night sky displays a stunning view of the Milky Way, illuminated by countless stars. The horizon is faintly lit, with distant mountain silhouettes visible against the serene backdrop.
Guesthouse in Elgin
4.99 out of 5 average rating, 146 reviews

Tiny House on Winery Row

Located on 15 acres in the heart of Elgin and Sonoita wine country on Winery Row. We have 4 dogs and chickens on property. You are welcome to our farm fresh chicken eggs for breakfast. Fire pit (local fire restrictions permitting). Great central location near Patagonia, Bisbee, Tubac, Tombstone etc. Green friendly outdoors. Queen sized bed is located in the loft, there is no full bedroom. Please inform us of pets. * This property is off grid and does not have WiFi.*

Top guest favorite
A single-story building constructed with natural stone and warm-toned stucco is set against a backdrop of grassy landscaping. A covered outdoor area is visible, along with a clear sky, creating a serene and peaceful setting.
Cottage in Patagonia
4.95 out of 5 average rating, 124 reviews

Country house with spectacular views

Disconnect from your worries in this spacious and serene private space, where you can enjoy natural light, contact with nature and beautiful natural views. It has a fully equipped kitchen, dining room, living room, living room with TV and reclining armchairs, 3 large bedrooms, a game room, laundry room and a beautiful porch where you can rest in the living room or in the outdoor dining room as well as enjoy beautiful sunsets. It also has a kiosk with lighting.

Top guest favorite
A large agave plant is positioned in the foreground, surrounded by decorative gravel. The casita's exterior features a combination of earthy tones with a garage door visible on the right. A glimpse of landscaped greenery and desert plants is seen in the background under a clear blue sky.
Guesthouse in Tubac
4.97 out of 5 average rating, 115 reviews

Cottage in the neighborhood

Your own casita with queen size bed and adjoining bathroom located 45 minutes south of the Tucson International Airport, a short 10-minute walk from the center of the charming and historic village of Tubac and steps away from the Anza trail for hiking and birding. With adjacent patio for your exclusive use and a private entrance, your casita will be the perfect “headquarters” for your visit to Southern Arizona or a great place to house your "overflow" guests!

Guest favorite
The exterior of the apartment features a vibrant yellow adobe wall, accented by a decorative horse motif. A wooden bench sits beneath a window with wrought iron detailing, while potted plants add greenery to the entrance. Rain-soaked surfaces reflect the surrounding colors.
Apartment in Nogales
4.94 out of 5 average rating, 223 reviews

Las Hacienditas Large Two-Bedroom Apartment

Located in the beautiful town of Rio Rico. Just a few minutes from the Mexican border and from the art community at Tubac. A few blocks from a beautiful walking trail, gymnasium and several churches. This private apartment has all the amenities you need for a short or long stay. We take all the necessary steps to make sure the space is sanitary by disinfecting all areas and washing all bedding and linens to protect you and your family or guests.

Superhost
Two spacious beds are arranged in the room, each dressed with soft grey blankets. A nightstand is positioned between the beds, and a light fixture above provides illumination. A small table is visible at the side, against a white brick wall.
Apartment in Nogales
4.86 out of 5 average rating, 123 reviews

Nice * Remodeled * Pool * Arizona 107

Welcome to the new Arroyo motel. The Arroyo is a part of Southern Arizona history, providing hospitality to guests for over 50 years. The entire property was upgraded with new tile and furnishings. All rooms come with free WI-Fi, cable TV, keyless access, microwaves, mini-fridges, access to our outdoor pool and free parking. The Pool closes at dusk. Pets are $5/day/pet, 1 pet per reservation.

Top guest favorite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 339 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines.

Popular amenities for Santa Cruz County vacation rentals