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Guesthouse vacation rentals in Mississippi River

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mississippi River guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Richfield
4.94 out of 5 average rating, 254 reviews

Peaceful weekend or extended stay, full amenities

BrianRating, 5 stars3 months ago
I had a great experience with Matt & Laura. They did a great job communicating and their property is very nice!
Guest favorite
Guesthouse in Galveston
4.91 out of 5 average rating, 655 reviews

Del Boca Vista -King bed/5 blocks from Strand

Annie Rating, 5 stars1 month ago
We loved this airbnb. It was perfect for our needs and the location can't be beat! We were able to walk to everything we needed and hop on our cruise the next morning stress free. The beds were 10/10 comfortable and the outdoor area is amazing. I would highly recommend staying here especially if you're looking for proximity to the cruise port and don't want to rent a vehicle. Thank you, Adana!
Top guest favorite
Guesthouse in Fayetteville
4.99 out of 5 average rating, 797 reviews

Private guest house

CalebRating, 5 starstoday
Very clean place and was as advertised. My friend and I are very active, so we enjoyed having the tennis/basketball court to play on. We also enjoyed seeing the deer in the back yard. Very reasonably priced for what we needed. We definitely enjoyed our stay and would be glad to stay again.
Top guest favorite
Guesthouse in Galveston
4.95 out of 5 average rating, 272 reviews

Crashboat Camp Apartment on the Bay

EricaRating, 5 stars2 weeks ago
I really loved the location, still on the water but quiet and away from the hub bub. I would absolutely stay here again. The hosts were wonderful too!
Guest favorite
Guesthouse in Cape Girardeau
4.94 out of 5 average rating, 512 reviews

Downtown Guesthouse- Romantic Getaway

TiffanyRating, 5 stars2 weeks ago
Cozy BnB, as described and as shown in the photos. Great location, nearby to businesses for food, coffee, and boutique shopping; it's convenient and walkable although in the daytime you can hear cars and people (a normal tradeoff for the convenience). Very private, considering the location as well, with a lot of character and thoughtfulness that went into this guest house. Laurie as a host is very friendly and helpful, and very responsive. We enjoyed this cute little place for a one-night stopover during a road trip.
Top guest favorite
Guesthouse in Neodesha
5 out of 5 average rating, 279 reviews

Neodesha Guesthouse - Quaint, No cleaning fee

ChrisRating, 5 stars5 months ago
I stayed here before. I also stayed at one of Kim's other places. She showed me a new place as well. I appreciated the no cleaning charge. I sure hope people treat her places nice so she and her husband can keep offering the same. Good luck Kim!
Superhost
Guesthouse in Green Bay
4.73 out of 5 average rating, 180 reviews

Guest house near Lambeau field

DanRating, 5 stars1 week ago
Great place to stay for the NFL Draft. Easy Uber access, but far enough away to escape the intensity of the event as needed. Daniel was a great host, keeping me informed right up to check-in. Will definitely consider renting again when I’m in Green Bay again.
Top guest favorite
Guesthouse in Batavia
4.91 out of 5 average rating, 294 reviews

Quaint Batavia Coach House

DianRating, 5 stars6 days ago
MaryBeth's place was so quiet and peaceful. I appreciated the convenient parking, comfortable bed and cozy atmosphere. Would definitely stay again!

Guest house rentals with a patio

Guest favorite
Guesthouse in Avinger
4.92 out of 5 average rating, 38 reviews

Adorable 2-bedroom guesthouse with wifi.

TammyRating, 5 stars1 month ago
Very peaceful stay. We loved the view of the lake and loved watching the deer.
Top guest favorite
Guesthouse in Poplarville
5 out of 5 average rating, 53 reviews

Adorable cottage with pool and hot tub

JoRating, 5 stars1 week ago
The guest house is a true gem! It has a charming interior and is located in a peaceful setting. Cindy, the hostess, is friendly and responsive. She lives nearby, which I find comforting because I usually travel to Poplarville alone. However, she allows her guests privacy. This is a wonderful place to stay.
Guest favorite
Guesthouse in Eudora
4.88 out of 5 average rating, 172 reviews

Cozy cottage getaway in garden paradise

AlexanderRating, 5 stars1 week ago
It was a wonderful get away for me and my partner, the place is cozy, inviting, and well maintained. Kris was fantastic with communication and we felt very welcome.
Top guest favorite
Guesthouse in Tupelo
4.94 out of 5 average rating, 597 reviews

Adorable 1 room guest house for 1 or 2 people

Kaine & MalloryRating, 5 stars1 day ago
Nice place to stop at on our drive home. Had a slight issue with parking due to city construction but the host messaged us beforehand. Wasn't a fan of the skylight in the home as it woke us up very early. This did not affect our overall rating and we liked the space.
Top guest favorite
Guesthouse in Pawhuska
5 out of 5 average rating, 104 reviews

Bell C Ranch Cottage - Country Setting

KadenRating, 5 stars1 month ago
Wonderful place to stay. Perfect location for me while working in town.
Guest favorite
Guesthouse in Lufkin
4.9 out of 5 average rating, 40 reviews

Adorable private studio apartment/guesthouse.

JeremyRating, 5 stars2 weeks ago
Everything was excellent. I have stayed here before and had a great stay. This one was no different!
Guest favorite
Guesthouse in Lone Jack
4.92 out of 5 average rating, 290 reviews

Adorable cottage on Beautiful property w/ hot tub

RachelRating, 5 stars3 weeks ago
The cottage was closer to the house than we preferred, but my sister and I had privacy. The hot tub was also closer to the house than we realized. Host was friendly & place was cute! Perfect overnight getaway from the kids & hubbies!
Guest favorite
Guesthouse in Beaumont
4.97 out of 5 average rating, 32 reviews

Petite Maison Guest House with Pool Views

JennaRating, 5 stars4 weeks ago
We had an amazing stay in Beaumont! Danielle, our host, was incredibly welcoming and made sure I had everything I needed for a comfortable stay. The space itself was absolutely lovely—spotlessly clean, well-decorated, and had everything I could have possibly needed for a relaxing and enjoyable stay. It felt like a home away from home, with thoughtful touches. I would highly recommend this place to anyone looking for a comfortable and pleasant stay. Would absolutely stay again!

Guest house rentals with a washer and dryer

Top guest favorite
Guesthouse in Hughes County
5 out of 5 average rating, 19 reviews

Guesthouse

WandaRating, 5 stars1 month ago
Oh goodness what a precious place! And precious folks that rented to us! We watched the sunset with the deer 🦌 while sitting on the outside swing! This place is perfect for a nice romantic getaway! We truly enjoyed our night! Everything was clean, organized and so quaint! We absolutely loved it!
Top guest favorite
Guesthouse in Hot Springs
4.99 out of 5 average rating, 137 reviews

Entire King Suite • Private Lake Balboa Guesthouse

TheresaRating, 5 stars5 days ago
The location was close to the golf courses we like to play, and the dedicated parking was nice. We enjoyed having coffee by the beautiful lake in the mornings. The host even had snacks (which were very much appreciated since grocery stores were not close by). The bed was very comfortable. We will come back!
Guest favorite
Guesthouse in Hancock
4.79 out of 5 average rating, 33 reviews

Fisherman's Village Guesthouse

ThomasRating, 5 stars1 week ago
What a beautiful little place! The view across the canal is fantastic and it’s just a short drive to Houghton / Hancock. It’s easy to drive by in the road but the host gave excellent instructions in check in and I was able to find it no problem even though I arrived at night. Would stay here again! The bathroom is on the bottom floor, so if you have issues with stairs, that would be an issue. Luckily no problem for me at all.
Top guest favorite
Guesthouse in Houston
5 out of 5 average rating, 170 reviews

Modern Guesthouse in the Heart of the Heights

JuanitaRating, 5 stars2 weeks ago
We really enjoyed this place. It was very clean and well kept. The hosts are very responsive. We loved everything about it.
Guest favorite
Guesthouse in Owasso
4.88 out of 5 average rating, 261 reviews

French Woods Quarters

KatRating, 5 stars1 month ago
Very inviting stay as pictured and described. Helpful hosts. It was nice to have a garage to park in and washer/dryer available. We loved the outdoor living space. We would stay again.
Top guest favorite
Guesthouse in New Orleans
5 out of 5 average rating, 129 reviews

Contemporary guesthouse near St. Charles Avenue

JacquelineRating, 5 stars4 weeks ago
I was traveling for a medical conference and the Airbnb was a short drive from the convention center. The hosts were very helpful with the check in process and were very accommodating to me and my family. I definitely recommend the apartment to anyone wanting to be close to the Garden District.
Guest favorite
Guesthouse in Little Rock
4.96 out of 5 average rating, 269 reviews

Farm in the City

DannyRating, 5 stars4 weeks ago
I highly recommend Robert's place for anyone staying in Little Rock. This is a really unique setting...a very private backyard with some land and a horse and beautiful trees...nestled into a Little Rock neighborhood. Very cool. The place is a great size for one or two people, is fully equipped with everything you need, and was clean and neat and just felt nice. I thoroughly enjoyed the back porch and outside table and chairs. The neighborhood felt safe and downtown Little Rock was about a 5 mile straight shot either down the freeway or Markham Street. Robert himself couldn't have been more friendly and helpful. I ran into some personal complications during my visit...unrelated to the Airbnb...and Robert truly went above and beyond to help me out.
Superhost
Guesthouse in Memphis
4.83 out of 5 average rating, 103 reviews

Cozy guesthouse studio | soaking tub | rain shower

SummerRating, 5 stars1 month ago
Austin and Ashleigh were the most amazing hosts! They worked with us when we needed to extend our stay by a night and the place we had was just amazing! Do not hesitate to book with them, you’ll feel right at home.

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