House vacation rentals in Los Santos Province

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Top-rated house rentals in Los Santos Province

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Pedasi

4.83 out of 5 average rating, 29 reviews

Beautiful home near the beaches in Pedasi, Panama.

Escape to paradise in this beautiful 2 bedroom 2 bath villa with full kitchen. A 5 minute walk to soak in the culture of the fishing village of Pedasi, where you will find unique dining experiences and exciting night life. A 10 minute drive will find you at clean, quiet beaches. Take a siesta in a provided hammock. Take a day trip to Playa Venao or Isla Iguana. We can also arrange for you to go deep sea fishing for mahi-mahi, tuna, sierra, rooster fish, sailfish or wahoo. Pet friendly (2 max).

Guest favorite

Home in Pedasí

4.95 out of 5 average rating, 148 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Guest favorite

Home in Chitré

4.88 out of 5 average rating, 50 reviews

Country House Like in the City / La Casita

Villa Oregon les ofrece una casa, fresca rodeada de árboles y naturaleza. Cuenta con áreas amplias para descansar. Ubicación céntrica, cerca de Centros comerciales, restaurantes, estación de autobuses y acceso directo a una ciclovía en Chitré. Tenemos facilidades como entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, aire acondicionado, agua caliente y WiFi. Los huéspedes contarán con fruta de bienvenida! ENG, POR, FRE and ITA Spoken!

Guest favorite

Home in Playa Venao

4.94 out of 5 average rating, 18 reviews

Next to Beach Club: Blue 2 Bedroom Family Villa

Villa 42, one of the closest to the beach in Blue! Kick back, relax in this calm, stylish Villa offering 2 restful bedrooms with comfy Queen beds. Fully equipped kitchen. Spacious lounging terrace. Perfect for couples, families, surfers or digital nomads. Complete amenities. Modern furnishings. WiFi, A/C and Laundry. Only steps away from Blue Venao ocean front beach club and restaurant with infinity pool, the magnificent Pacific Ocean, surfing, dining, activities and nightlife.

Guest favorite

Home in Pedasí

4.92 out of 5 average rating, 12 reviews

Ocean View From The Jungle!

Welcome! This home is located in a very private and serene location far from neighbors. It has 4 well-appointed bedrooms, each boasting its own private bathroom and adorned with luxurious 100% Egyptian cotton bed linens. The kitchen is fully equipped with all the essentials, from cooking basics to a large variety of pots and pans, allowing you to prepare meals for all with ease. The view from the pool is spectacular, offering a refreshing oasis for relaxation and enjoyment.

Superhost

Home in Playa Venao

4.83 out of 5 average rating, 12 reviews

Modern Beach Home with pool and hot tub

Welcome to our tropical modern 3 bedroom, 3 bathroom newly built home in Playa Venao. This house is made for indoor/ outdoor living with huge glass sliding doors connecting the living spaces to outdoor spaces. The pool, hot tub, large covered patio with BBQ, and lush landscaping will make you feel like you are in a private resort. The house is on the beach side of the main road, just a short walk to a very private and tranquil part of the beach on Playa Venao.

Superhost

Home in Chitré

4.8 out of 5 average rating, 60 reviews

NINA HOUSE, spacious and cool house in Chitré.

House just for you, up to 7 p, spacious and in one of the best areas of Chitré, quiet and family, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and stop at Nina House and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with a fast internet. We now have air conditioning in the living room for your comfort.

Superhost

Home in Playa Los Destiladeros

5 out of 5 average rating, 3 reviews

Pedasí, Playa Los Destiladeros / Casa Serena

❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Guest favorite

Home in Playa Venao

4.97 out of 5 average rating, 32 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Superhost

Home in Búcaro

4.85 out of 5 average rating, 41 reviews

Casa Iguana 3 -Sleep 4-queen bed & 1 bunk bed

Enjoy our spacious house perfect for friends and families within the private grounds, lounging in a hammock or playing in our large pool while enjoying the beautiful views of Bucaro beach surrounded by flowering bougainvillea. We offer full kitchens, starlink internet. Situated steps away from the sandy beach Be warned there are active cantinas nearby which can be noisy on weekends. I also have another house, for 8 people, casa iguana 2, next door

Guest favorite

Home in Playa Venao

4.96 out of 5 average rating, 25 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Guest favorite

Home in La Villa de Los Santos

4.96 out of 5 average rating, 75 reviews

Spacious Casa Villa de los Santos

Your family will have everything just a step away in this accommodation, in La Villa de Los Santos. This cozy space offers living room, equipped kitchen, comfortable rooms, spacious portal, patio, Wi-Fi, A/C and parking .Located near squares and super markets. It's the perfect base to explore the natural beauty of the region. This place has Playas such as El Rompió y Monagre 15 min, Isla Iguana 45 min, Playa Venao 1 hour 30 min.