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Vacation rentals in Los Santos Province

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Top-rated vacation rentals in Los Santos Province

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost

Home in Pedasí

Ocean View From The Jungle!

Welcome! 20% off for March Madness!! This home has been recently updated & returned to its original glory. There are 4 well appointed bedrooms, each has its own private bathroom. All bed linens are 100% egyptian cotton. The kitchen is very well stocked and you can be sure that you will be able to cook amazing meals for the whole family. Enjoy your meals outside, overlooking the pool and the jungle or inside... as there are 2 dining areas . The pool is nothing short of spectacular!

Aug 20 – 27

$283 per night$2,030 total
Guest favorite

Home in Pedasí

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Aug 30 – Sep 6

$149 per night$1,267 total
Guest favorite

Tiny home in Playa Los Destiladeros

Casita Brisa del Mar

Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula. This is generally a quiet neighborhood. FULL DISCLOSURE, there is currently construction happening next door to this property. The lowered price reflects this.

Apr 22 – 29

$99 per night$844 total

Popular amenities for Los Santos Province vacation rentals

Other great vacation rentals in Los Santos Province

Guest favorite

Home in La Villa de Los Santos

Amplia casa Villa de los Santos

Apr 5 – 12

$85 per night$718 total
Guest favorite

Home in Playa Venao

Casa Samambaia - sea view tropical paradise w pool

May 14 – 21

$286 per night$2,051 total
Guest favorite

Villa in Playa Venao

Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao

May 13 – 20

$153 per night$1,279 total
Guest favorite

Guesthouse in Pedasi

A Remote Paradise in nature - Ocean View

May 4 – 11

$122 per night$1,010 total
Guest favorite

Guesthouse in Pedasi

Casa de la Amor Casita

Aug 13 – 20

$110 per night$913 total
Guest favorite

Vacation home in Playa Los Destiladeros

Curcu House: magical beach house & tropical forest

Jun 17 – 24

$137 per night$1,135 total
Superhost

Home in Cambutal

Casa Concha and Luna Negra

Sep 24 – Oct 1

$155 per night$1,283 total
Superhost

Villa in PA

Villa Estrella in Playa Venao

Apr 20 – 27

$167 per night$1,197 total
Guest favorite

Villa in PA

Playa Venao, Blue Venao Beach Resort Villa 30

Mar 25 – Apr 1

$399 per night$3,187 total
Guest favorite

Villa in Cañas

Residence Denter Tumas

Apr 20 – 27

$500 per night$3,500 total
Guest favorite

Vacation home in Las Escobas del Venado

3 BR Family Surf Villa - Benow in Playa Venao

Dec 26 – Jan 2

$520 per night$4,209 total
Guest favorite

Home in Playa Venao

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa

Jun 10 – 17

$314 per night$2,549 total

Destinations to explore