
Guesthouse vacation rentals in Charleston
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Charleston
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Charleston guesthouse rentals
Family-friendly guest house rentals

Guesthouse in James Island
4.91 out of 5 average rating, 690 reviewsIsland Oasis—Near Downtown

Guesthouse in West Ashley
4.93 out of 5 average rating, 745 reviewsCharleston's Coolest Neighborhood

Guesthouse in West Ashley
4.95 out of 5 average rating, 367 reviewsThe White House of Avondale

Guesthouse in Summerville
4.88 out of 5 average rating, 787 reviewsNew Loft in Historic Summerville

Guesthouse in Mount Pleasant
4.94 out of 5 average rating, 248 reviewsGreen Garden Studio @greengardenstudio2017

Guesthouse in Charleston
4.99 out of 5 average rating, 285 reviewsSpacious Daniel Island Apartment

Guesthouse in James Island
4.92 out of 5 average rating, 344 reviewsMother in Law in James Island Riverland Terrace

Guesthouse in James Island
4.84 out of 5 average rating, 116 reviewsRomantic Beach Style Cottage close to everything!
Guest house rentals with a patio

Guesthouse in Summerville
4.81 out of 5 average rating, 16 reviews3 Mins from downtown Summerville

Guesthouse in West Ashley
4.94 out of 5 average rating, 224 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)

Guesthouse in Summerville
4.99 out of 5 average rating, 68 reviewsHearts & Dreams Peaceful Family Retreat w/ pool

Guesthouse in James Island
4.79 out of 5 average rating, 143 reviewsGuest Suite by the Beach

Guesthouse in James Island
4.97 out of 5 average rating, 58 reviewsCountry in the City, "The Outback"

Guesthouse in Johns Island
4.98 out of 5 average rating, 102 reviewsDriftwood Cottage

Guesthouse in Park Circle
4.92 out of 5 average rating, 121 reviewsMy Happy Place

Guesthouse in James Island
4.99 out of 5 average rating, 131 reviewsThe James: “Tiny” Home b/w Downtown & Folly
Guest house rentals with a washer and dryer

Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 136 reviewsGroves Carriage House, near Shem Creek

Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 142 reviewsBeach, downtown, Alhambra Hall weddings so close!

Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 240 reviewsCozy Apartment in Mount Pleasant

Guesthouse in West Ashley
4.9 out of 5 average rating, 602 reviewsCute, Cozy Cottage | Bike Path | King Bed

Guesthouse in Mount Pleasant
4.94 out of 5 average rating, 107 reviewsPrivate Coastal Cottage-Near Beaches & Charleston!

Guesthouse in James Island
5 out of 5 average rating, 244 reviewsJames Island "La Casita" Nestled btw Beach & City

Guesthouse in Summerville
4.96 out of 5 average rating, 251 reviewsSummerville’s Tiny Oak Hideaway

Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 276 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Quick stats about guesthouse rentals in Charleston
Total rentals
220 properties
Total number of reviews
25K reviews
Family-friendly rentals
40 properties are a good fit for families
Pet-friendly rentals
50 properties allow pets
Rentals with a pool
10 properties have a pool
Rentals with dedicated workspaces
90 properties have a dedicated workspace
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- Family travel hub Tips and inspiration
- Family budget travel Get there for less
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- Kid-friendly state parks Check out these family-friendly hikes