
Guesthouse vacation rentals in Anderson County
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Top-rated guesthouse rentals in Anderson County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
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Popular amenities for Anderson County guesthouse rentals
Family-friendly guest house rentals

Guesthouse in Pendleton
4.89 out of 5 average rating, 253 reviewsLa Bella Farm
This place was exactly what we needed! We had a group of four come down for a Clemson game. We brought an air mattress but the place was plenty big for the four of us. The kitchen was stocked and the place was clean. The hosts were very friendly and prompt with any questions. Would definitely stay here again!

Guesthouse in Liberty
4.93 out of 5 average rating, 192 reviewsHolly Hideaway! 10 Highway miles to Clemson U!
Close to grocery stores and restaurants; less than half an hour from Table Rock, less than 20 minutes away from Clemson Host very friendly and responsive Nice walk in shower with a seat and plenty of hot water and good pressure very warm and cozy even though it was below freezing outside Very comfy bed! Pet friendly!

Private room in Pelzer
4.98 out of 5 average rating, 124 reviewsSouth Oaks Guesthouse
I love staying here. My second visit went just as well as the first. Feels like home. Great shower and comfortable bed. always love the cake and flowers. Peaceful and I love that there is no TV. Very relaxed setting can come and go with freedom and ease.

Guesthouse in Donalds
4.99 out of 5 average rating, 363 reviewsHome on the farm
Our time spent at the guest house was well worth it! We enjoyed the private and peaceful area! At night we watched the grazing deer in the morning we bird watched! The house is also only a short drive from Abbeville and Greenwood! Both are charming places to explore! Ruth and Bob are amazing hosts and we would definitely recommend them and stay again!

Guesthouse in Townville
4.86 out of 5 average rating, 249 reviewsLisa’s Lodge
Very cozy quaint spot! Perfect for our weekend getaway to catch a few Clemson events! Will definitely be back!
Guest house rentals with a patio

Guesthouse in Seneca
5 out of 5 average rating, 32 reviewsOne Particular Cove ... on Lake Hartwell
Genny and Sid's place was perfect. It was spotless, cozy, and had a great view. We felt like we were home and would love to go back. They were great hosts. They had snacks and water ready for us and when we left a coat in their closet made sure it got in the hands of one of our friends coming through the area. I highly recommend this place!

Guesthouse in Pelzer
5 out of 5 average rating, 28 reviewsBirdsong Bungalow-$99 weeknights in Feb!
This was a great place for us to stay. Amy was a great host and we would definitely stay here again.

Guesthouse in Clemson
5 out of 5 average rating, 38 reviewsDowntown Clemson Guest Suite!
Fantastic place close to downtown but secluded. Well appointed. Nice features of snacks and drinks.

Guesthouse in Clemson
5 out of 5 average rating, 21 reviewsAdorable Cottage 2 mi. from Death Valley
We had a wonderful stay at Harold and Bonnie’s place. It was a home away from home while we attended a Clemson football game and visited our niece. Everything was spotless, comfortable and welcoming. It was so nice to meet and chat with Harold and Bonnie and we really appreciated the welcome muffins and available snacks that helped us survive our flight home! Would definitely recommend their place to anyone visiting Clemson and have already told our family to book it next time they visit.

Guesthouse in Central
5 out of 5 average rating, 14 reviewsVacation Home Clemson and Lakes
This home was just as described, and a comfortable place while we helped our daughter move into her apartment. Super close to Clemson, but quiet and private at the same time. Enjoyed our stay- will stay again! Thanks for having us!

Guesthouse in Seneca
5 out of 5 average rating, 15 reviewsQuin's Lake House, Keowee. Private bottom Floor.
Lawrence was very responsive and helpful enjoyed the stay

Guesthouse in Greenville
5 out of 5 average rating, 13 reviewsCasita Guest House- Country Feel- Great Location
Dans place was very clean and modern. Super spacious in a very quiet location with relaxing woods behind the property. Easy access to Greenville, restaurants and the interstate. Dan was very responsive and accommodating. Great stay!
Guest house rentals with a washer and dryer

Guesthouse in Greenville
4.8 out of 5 average rating, 64 reviewsTheArk
David was very accommodating on a last minute basis. Very nice place to stay while visiting the area.

Guesthouse in Clemson
4.93 out of 5 average rating, 15 reviewsClemson Carriage House - NEW!
A very comfortable, roomy and cute guest house that I would gladly return to! It is very well stocked and extremely neat and clean. Great location and nice quiet neighborhood. :)

Guesthouse in Anderson
4.94 out of 5 average rating, 183 reviewsPrivate-Lake getaway-7 mile view from dock
Here’s a draft for your review: Review Title: Fantastic Stay at Art’s Place – Highly Recommend! Review Body: I had an incredible stay at Art’s place on Lake Hartwell. Art was an excellent host—very communicative and always available to answer any questions. From the moment I booked, he provided detailed and helpful information that made the trip smooth and enjoyable. The property itself was clean, cozy, and exactly as described. The location on the lake was beautiful and peaceful, perfect for a relaxing getaway. The amenities were well thought out, and Art’s attention to detail really stood out. I highly recommend staying here if you’re visiting Lake Hartwell or the area. Art’s hospitality and the overall experience exceeded my expectations. I’ll definitely be returning!

Guesthouse in Pelzer
4.95 out of 5 average rating, 58 reviewsQuaint guest cottage in Upstate
We found the cottage very quant, comfortable and clean. It had everything you would need for a comfortable stay. We would definitely stay again if we are in the area.

Guesthouse in Townville
5 out of 5 average rating, 9 reviewsParadise Point on Lake Hartwell
Paradise point was wonderful! Easy check-in, kids loved the game room, and the dock made it easy for kayaking & docking our boat. We will be back for sure!

Guesthouse in Anderson
4.85 out of 5 average rating, 189 reviewsFarmhouse by the lake - Private guest house
If you are looking for a quiet rustic little get away, this is perfect. At first we were unsure what we were getting ourselves into because about 2 min away the neighborhood seemed to not match the pictures but then out pops this cute newer neighborhood that feels warm and welcoming. Things we loved: - The open woods behind us - quiet secluded neighborhoods - lots of room to play - the stuff inside was very kid/toddler friendly (no fancy glass I was worried about breaking) - EXTRA fuzzy warm blankets in each closet! Things to expect: - The entryway is unfinished with plywood which didn’t bother us and actually made us feel right at home. - kitchen was good but not a lot of serving bowls if you need them, bring your own. - the closes grocery store is about 10 min away - there was a variety of coffee which was perfect but no decaf so I would bring your own. - you need to go to the goat farm like 5 min down the street. Delicious cheese/milk. We will definitely be back here again

Guesthouse in Townville
4.67 out of 5 average rating, 6 reviewsBeautiful Luxury home on Lake Hartwell by Clemson
Great place & location for peace and sound. Would highly recommend to stay there again.

Guesthouse in Clemson
5 out of 5 average rating, 13 reviewsRiggs Drive Gameday Getaway
Jess and Celeste were great hosts. The apartment was clean, updated, and looked just like the pictures. The location was great and near downtown Clemson and the stadium. I highly recommend this property for anyone looking to stay in Clemson.
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