Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

A panoramic view captures the surrounding mountains and lush landscapes, with a mix of greenery and water bodies visible below. La Piedra de Peñol is prominently featured on the right, overlooking the expansive reservoir and hills stretching into the distance under a bright blue sky.

Treehouse in El Peñón de Guatapé

4.94 out of 5 average rating, 121 reviews

Treehouse in El Peñol - 360° views of stone

Enjoy the sounds & privacy of nature at this unique cabin in the trees ATOP the closest mountain to Piedra de Peñol. *IMPORTANT NOTES!* Though nicely located in nature, IT'S A TREEHOUSE CABIN IN & ON TOP OF MOUNTAINS, not a resort downtown. *PRICES CHANGE DEPENDING ON NUMBER OF PEOPLE (AB&B's POLICY!) Located as high as La Piedra de Peñol with better views than from the rock as you're able to see it as well! The cabin's isolated away from roads, noises of civilization & surrounded by reserves.

Top guest favorite

The exterior of the house features a modern design, surrounded by lush greenery and trees. A wooden deck area is furnished with comfortable seating, framed by landscaped plants, inviting relaxation in a serene natural setting.

Cabin in San José

4.96 out of 5 average rating, 227 reviews

"Tierra Grata" House in Rionegro-Antioquia

This house has respected the environment in which it was created. With a forest around, you can see many kind of birds and squirrels, it is a space surrounded by nature, quiet, where you can rest. You have comfortable spaces. The cabin consists of 1 room with a double bed. 1 large bathroom, dining room and a teak deck. Totally equiped. From here, you can go visit Guatapé and Peñol stone (1 hour), the ceramics of Carmen de Viboral (45min), the Arvi park in Santa Elena (45 min) and Llanogrande.

Top guest favorite

An outdoor deck area features a hammock hanging beside a small jacuzzi, complemented by a dining table for four. Large sliding doors provide a view into the interior space, where a cozy atmosphere is highlighted by warm lighting and natural wood elements.

Villa in Rionegro

4.97 out of 5 average rating, 151 reviews

Sweet Helen Llanogarden

Sweet Helen Llanogarden situado en el Tablazo-Llanogrande, a tan solo 10 minutos del aeropuerto internacional José Maria Córdova de Rionegro Antioquia, cerca a restaurantes, centros de eventos y malls, en el cual ofrecemos servicios de alojamiento para familias, amigos, parejas y viajes de negocios. En Sweet Helen Llanogarden encontrarás el espacio para pasar una estancia segura, tranquila y divertida, esta vez, rodeada de naturaleza y confort en la zona más exclusiva del oriente antioqueño.

Guest favorite

A modern chalet is set against a lush green hillside, featuring large glass windows and a sleek design. A jacuzzi and a sunken fire pit are situated in a landscaped area, with stone paths leading to seating spaces. Scenic views of the surrounding nature are visible.

Cabin in La Ceja

4.98 out of 5 average rating, 137 reviews

Chalet Los Alpes

Chalet Los Alpes. We are located in La Ceja via La Unión with one of the most spectacular views in the region. With home automation system. You can enjoy green areas, a Jacuzzi, a built-in fire pit, a cinema, a VIP office, two living rooms, a kitchen, 2 bedrooms with private bathroom, 2 closets, fiber optic connection, WiFi area throughout the villa, laundry area, reading area, mobile connectivity, ample parking for 4 cars. Be amazed and visit Chalet Los Alpes, because “Life begins here”.

Guest favorite

An outdoor terrace is presented, featuring a jacuzzi, a barbecue grill, and lounge seating. The space contains several chairs arranged around a fire pit, along with a table for dining. The area is brightened by natural light and offers views of the surrounding environment.

Condo in El Carmen de Viboral

4.92 out of 5 average rating, 228 reviews

Modern and Cozy Condo El Cóndor -Carmen Viboral

Beautiful and cozy apartment in the center of Carmen de Viboral with 1 well-equipped master bedroom, a spacious and bright living room with sofa bed, access to terrace, fully equipped kitchen, bathroom and jacuzzi. This apartment has a beautiful view of the town and excellent areas to share as a couple or as a family. It is located 1 minute from the main park, close to pharmacies, ATMs, supermarkets, restaurants and others. This is the preferred place to rest and relax.

Guest favorite

Cabin in Rionegro

5 out of 5 average rating, 18 reviews

The Ultimate Group House w/ Hot Tub & Amazing View

About this space 🌟 2 bedrooms, each with a double bed & private bathroom 🛏️ Double sofa bed in the living room 🛋️ Bathrooms with hot water & fresh towels 🚿 Living room with Smart TV & WiFi 📺 Private jacuzzi for relaxation 💦 Fully equipped kitchen 👩‍🍳 Gas BBQ grill for cookouts 🍖 Catamaran net, dining table & spacious deck/terrace 🌞 Private parking space 🅿️ Portable heater available 🔥 Breakfast available upon request, prepared by our staff with extra cost 🍳

Top guest favorite

A wooden cabin is situated on a hillside, surrounded by lush greenery. Large windows provide views of the landscape, while a deck with a railing offers seating for outdoor enjoyment. The sky above is illuminated with soft pastel colors at dusk.

Cabin in La Unión

5 out of 5 average rating, 75 reviews

Wooden Mountain Cabin with lounge net, fast wifi

Enjoy a discount when you book more than one night! Relax in our wooden mountain cabin with stunning Andean views with total privacy for nature lovers. Equipped with a kitchen, fridge, water filter, hot shower, comfy bed, a working place with high speed internet and longe net for daytime relaxation and stargazing at night. The deck offers a perfect spot to enjoy the breeze and birdwatch. Explore nearby attractions like the Salto Del Buey waterfall and short hikes.

Top guest favorite

The exterior of a modern cabin is shown, featuring a sharply angled roof and large windows that invite natural light. Surrounding trees enhance the serene environment, while subtle outdoor lighting adds to the ambiance.

Cabin in Retiro

5 out of 5 average rating, 31 reviews

Camino del Ciprés Boutique Cabin

Camino del Ciprés is a completely private boutique cabin located in a nature reserve in El Retiro, Antioquia. Surrounded by the tranquility of a pine forest, rivers and birdsong. Ideal for rest and connection with nature that you can enjoy with family or friends. Enjoy a warm and cool environment, perfect for contemplating the forest or going hiking. We have hot water, a Jacuzzi, catamaran net, fireplace, kitchen, WiFi, TV, and a terrace for barbecues.

Top guest favorite

A modern structure emerges from lush greenery, framed by vibrant plants and a manicured lawn. Large glass doors lead to a spacious deck, offering a view of the mountains and a colorful sky. Pathway stones create a welcoming entrance.

Home in La Ceja

4.93 out of 5 average rating, 44 reviews

Country house, excellent location, beautiful view!

We invite you to enjoy a beautiful space surrounded by nature, with all the comforts so you can relax and rest. You will feel like you are right at home. Ideal place for telecommuting (digital nomads) and long stays. Just 10 minutes from La Ceja, 45 minutes from the international airport and about 1 hour from Medellin. Pets are welcome. Additionally we offer Yoga classes and Ayurvedic therapies (Abhyanga/Swedana). Perfect place for "slow" tourism!

Top guest favorite

The exterior of the house is illuminated with warm lighting, showcasing a modern structure situated amidst lush greenery. A spacious deck is visible, enhancing the inviting atmosphere as it blends with the natural surroundings under a twilight sky.

Home in Rionegro

4.96 out of 5 average rating, 225 reviews

A warm house with a Jacuzzi, 5 minutes from JMC airport

Welcome to our cozy loft house just 5 minutes from JMC Airport, it is perfect for a relaxing getaway close to everything. Space for 4 people, offers all the amenities you need for a comfortable stay, it is complete/equipped with all the kitchen implements so you can prepare your favorite meals. In addition, it has a parking lot, WiFi, jacuzzi , deck and catamaran mesh for a unique experience, smart TV. NO parties or loud music

Top guest favorite

A covered jacuzzi is visible in the foreground, with bubbling water inviting relaxation. In the background, two hammocks are strung between trees, set against a lush green landscape and a wooden structure that complements the serene setting.

Farm stay in Retiro

4.98 out of 5 average rating, 125 reviews

"Authentic Antioquia Farm with All the Comforts"

Finca Sietecueros - Natural Refuge and Comfort in One Place Escape to Finca Sietecueros, a country house surrounded by forests and mountains. Relax in the jacuzzi, enjoy the hammocks under the trees, or share stories in the campfire area under a starry sky. Ideal for couples, families, and friends seeking peace, nature, and comfort in a unique setting. Book your stay and live an unforgettable experience in contact with nature!

Top guest favorite

The cozy cabin is nestled in a lush green landscape, illuminated by warm outdoor lights. A wooden deck features comfortable seating, overlooking the serene surroundings. Large windows provide a glimpse of the interior, showcasing a warm and inviting space harmonized with nature.

Farm stay in Rionegro

4.95 out of 5 average rating, 269 reviews

Lumberjack's House | Secluded nature retreat

🪓 Retreat Cabin – Lumberjack's House is our dream home. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend or work remote in a distraction-free environment. Wake up to the singing of the birds at sunrise and enjoy a fire on the deck at sunset. In Retiro Cabin you will have total independence and an unparalleled view of the countryside in the Antioquia East.