Guesthouse vacation rentals in Panama
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Panama
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Nueva Gorgona
4.99 out of 5 average rating, 67 reviewsBeautiful Casita-Paradise in Panama, Nueva Gorgona
Guesthouse in Alto Boquete
4.82 out of 5 average rating, 65 reviewsAccommodation. Sinsonte )
Guesthouse in Bocas del Toro Province
5.0 out of 5 average rating, 4 reviewsLas Palmas Casita at Bluff Beach Retreat
Guesthouse in Jaramillo Arriba
4.92 out of 5 average rating, 37 reviewsCaramel house
Guesthouse in Boquete
5.0 out of 5 average rating, 9 reviewsVista a Baru
Guesthouse in Chicá
Villa Altos de Campana, guess house for 6
Guesthouse in Panamá
Mochila & Art Family House
Guesthouse in Panamá
4.92 out of 5 average rating, 38 reviewsPrivate cabin and CasaMomote River, Loma Limón.
Guest house rentals with a patio
Guesthouse in Bajo Boquete
4.93 out of 5 average rating, 30 reviewsRustic Private Studio Near Downtown
Guesthouse in Anton Valley
4.89 out of 5 average rating, 45 reviewsPrivate 1 BR cottage near India Dormida hiking
Guesthouse in Anton Valley
4.83 out of 5 average rating, 18 reviewsCabin The India
Guesthouse in El Valle de Antón
5.0 out of 5 average rating, 4 reviewsPrivate Suite/Studio 1-Bedroom in Paradise
Guesthouse in Alto Boquete
4.82 out of 5 average rating, 17 reviewsBungalow Villa Castillo, Boquete.
Guesthouse in Rio Sereno
5.0 out of 5 average rating, 3 reviewsThe Farmer’s Shack - Pure Nature
Guesthouse in Almirante
4.63 out of 5 average rating, 49 reviewsGia's Garage & Home for Bocas travelers
Guesthouse in Almirante
4.84 out of 5 average rating, 25 reviewsEntire guesthouse in Almirante, Bocas
Guest house rentals with a washer and dryer
Guesthouse in Bocas del Toro
4.88 out of 5 average rating, 16 reviewsTiny Studio w/ pool access
Guesthouse in Nueva California
5.0 out of 5 average rating, 13 reviewsVolcan Cloud Forest Escape for two
Guesthouse in Boquete
4.67 out of 5 average rating, 9 reviewsCozy Studio Unit with Jawdropping Views!
Guesthouse in Río Hato
4.88 out of 5 average rating, 65 reviewsSustainable Guest house with Pool in Rio Hato
Guesthouse in Boquete District
5.0 out of 5 average rating, 9 reviewsDuplex 1
Guesthouse in Cambutal
4.83 out of 5 average rating, 6 reviews"La Jungla" Cabaña close to the beach
Guesthouse in Los Naranjos
4.69 out of 5 average rating, 61 reviewsCabaas de Alicia 1
Guesthouse in Torio
4.8 out of 5 average rating, 5 reviewsCozy cabin w/ Queen Bed & ensuite mins from Beach
Destinations to explore
- Rentals with a fireplace Panama
- Rentals with breakfast Panama
- Kid-friendly rentals Panama
- Rentals with pools Panama
- Rentals with a patio Panama
- Farmstay rentals Panama
- Cottage rentals Panama
- Smoking-friendly rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Island rentals Panama
- Treehouse rentals Panama
- Hotel rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Fitness-friendly rentals Panama
- Apartment rentals Panama
- Boutique hotel rentals Panama
- Nature eco lodge rentals Panama
- Vacation home rentals Panama
- Rentals with an accessible height bed Panama
- Monthly Rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Boat rentals Panama
- Waterfront rentals Panama
- Bed and breakfasts Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- House rentals Panama
- Rentals with a home theater Panama
- Condo rentals Panama
- Rentals with a washer and dryer Panama
- Beach house rentals Panama
- Pet-friendly rentals Panama
- Bungalow rentals Panama
- Townhouse rentals Panama
- Rentals with beach access Panama
- Loft rentals Panama
- Rentals with a sauna Panama
- Rentals with a hot tub Panama
- Wheelchair accessible rentals Panama
- Rentals with lake access Panama
- Villa rentals Panama
- Rentals with a fire pit Panama
- Family-friendly rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Tiny house rentals Panama
- Beach condo rentals Panama
- Chalet rentals Panama
- House rentals Panama City
- House rentals Playa Coronado
- House rentals Altos del Maria
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes