Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Villa in Panamá
Beautiful House in Panama w/ King Beds + Pool
Home in Río Hato
Spectacular beachfront house in Buenaventura!
Home in Playa Bluff
Jungle House 100m from the beach
Rental unit in Río Hato
4 Bedroom Private Pool Paradise in Buenaventura
Home in San Carlos
Beach House-Ocean View Rooftop Jacuzzi & Pool
Rental unit in Panamá
Top Floor Condo 6 bedroom with amazing views
Villa in Portobelo
Entire Villa with pool in front of beach!
Condo in Maria Chiquita
Playa Escondida Lux Beachfront Haven:Oceanview Apt
Luxury mansion rentals
Rental unit in Maria Chiquita
Spacious 4Br Beachside Getaway at Playa Escondida
Villa in Punta Chame
FREE NIGHT Amazing Beachfront Villa - Palm House
Villa in Bejuco
Beach house in Punta Chame, Villa frente al mar
Villa in Río Hato
Secluded Villa in Buenaventura Golf and Resort
Rental unit in Maria Chiquita
Penthouse in Playa Escondida 4 bedrooms
Home in Gamboa
BirdHouse@ Gamboa Panamá Canal
Villa in Río Hato
(Panama) Beach house with golf course.
Home in Anton Valley
Lovely and Cousy house at El Valle
Pet-friendly mansion rentals
Condo in San Carlos District
Punta Caelo Beach Front View
Villa in Costa Esmeralda
#1 Villa with pool, jacuzzi, pool table, ping pong.
Home in San José
αlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Bocas del Toro
Casa del Mar - eco aqua villa
Home in Panamá
Wonderful House with Terrace and Sea View
Villa in Costa Esmeralda
Spectacular 600-meter oceanfront beach house
Rental unit in El Chirú
Buenaventura Golf & Beach Resort Lux Apartment
Home in Pedasí
Ocean View From The Jungle!
Destinations to explore
- Beach house rentals Panama
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- Monthly Rentals Panama
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- Townhouse rentals Panama
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- Family travel hub Tips and inspiration
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- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes