Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 345 reviews

Diamond Villa in the Heart of Pacific Beach

3 blocks to the beach & 2 blocks off main st, newly constructed detached living space w/private entrance & shared yard: spacious 1 bedroom, 1 bath, lg living rm w/an accordion glass door to patio/deck, 2 flat screen TVs w/cable & wifi , leather sofas, gas fireplace, kitchenette, gas grill, propane heater on deck, top level has wet bar, chairs & gas fit pit, bay & ocean peek views from top level, private entrance, outdoor warm shower for after beach rinse, Jacuzzi & wood fire pit in shared yard

Guest favorite

Guesthouse in Escondido

4.92 out of 5 average rating, 640 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Guest favorite

Guesthouse in San Diego

4.99 out of 5 average rating, 188 reviews

Tropical on Texas

Private casita (studio) with kitchenette, day bed with trundle so easily can accommodate two singles or can become a king size bed. Very near zoo, shopping, restaurants, stadium, minutes from Sea World, downtown, convention center, Gaslamp, airport, beaches/bay. Immediate freeway access, 5 minutes to trolley, bus stop at corner. Great walk-ability. If you would like a taste of paradise & central location we look forward to your visit. Please no extra guests they may come to visit but not stay.

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 449 reviews

Private Cottage in Walkable North Park w/AC

Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 357 reviews

Cozy Ocean Beach Casita

This cozy, clean casita is just 4 blocks to the beach, pier, great surfing, restaurants, bars, shopping, and Sunset Cliffs. You’ll love it for its walkability to everything you need. The casita is only 120 square feet, a very small space (small studio with everything in one room including the bathroom), for single occupancy only, but with everything you need to enjoy a San Diego getaway. It is great for solo travelers who want to be near the heart of Ocean Beach, San Diego, California.

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 286 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Guest favorite

Guesthouse in San Diego

4.98 out of 5 average rating, 185 reviews

North Park Garden Retreat Casita

Nestled between the urban neighborhoods of North and South Park, our sanctuary within the heart of the city is surrounded by a secret garden that gives the impression of a tropical oasis. The private casita is tucked in the backyard of the Host’s home and has french doors which open to the lush greenery of the garden. Whether vacationing, traveling for work, or looking for an ideal space for relaxation and renewal, this is the perfect place to enjoy your San Diego stay.

Guest favorite

Guesthouse in San Diego

4.91 out of 5 average rating, 357 reviews

La Casita - Fully Updated Casita in Mission Hills

This well designed, fully updated detached studio casita is located in one of the most sought after neighborhoods in San Diego - Mission Hills. Surrounded by a serene garden courtyard with private entry and quiet patio. Close to great dining, grocery stores and shopping, and a mere 10 minutes or less to most of San Diego’s main attractions. If you are coming by car, there is plenty of free street parking - otherwise Ubers are plentiful and reasonably priced.

Guest favorite

Guesthouse in San Diego

4.91 out of 5 average rating, 415 reviews

Mission Hills Charming suite, walkable to all.

Heart of Mission Hills, upscale area, this private guest suite, separate from the house, is perched above the pool (separate building from main house), own entrance; sure to provide privacy. We are minutes from airport, walking distance to coffee & restaurants and central to all of SD. Please note this property is wiped down after each visit with Clorox as well as all linens washed. We also don’t rent back to back giving time for thorough cleaning.

Guest favorite

Guesthouse in San Diego

4.91 out of 5 average rating, 153 reviews

Relaxing Oasis - short walk to shops & recreation

The Zen Den- This small oasis boasts a location that offers the best of both worlds: a quiet sanctuary for some tranquil R&R, and close proximity to San Diego’s best nightlife, sightseeing, and recreation. The studio opens up to an outdoor patio perfect for San Diego’s sunny and 70 weather. Your blissful retreat is located one block from the bustling metro district of Hillcrest with coffee shops, restaurants, parks, walking/running trails, and more.

Guest favorite

Guesthouse in San Diego

4.96 out of 5 average rating, 125 reviews

Brand New Modern North Park View Apartment

This brand new North Park apartment is the perfect place to enjoy San Diego. The home is located on a quiet street in close proximity to Balboa Park, the San Diego Zoo, Downtown, Sea World, Old Town, Coronado Island, Seaport Village, and the airport. It is in walking distance to a number of renown restaurants, coffee shops, and breweries. Beautiful sunset views allow you to relax after a long day of taking in the city.

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 193 reviews

California Cottage in North Park

Walking along side the main house into this secluded cottage, you’ll embark on your own vacay just 10 minutes from the airport. This converted separated garage is a home away from home with walking distance to University Ave with Communal Coffee for breakfast, and outdoor dinner dinning at Louisiana Purchase. If the zoo is what you desire, it is not a far walk but a little hike through the canyon is required.