Vacation home rentals in South Carolina

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in South Carolina

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A yellow and white striped lounge chair is positioned on a wooden deck, overlooking a lush green marsh. The still water reflects the surrounding nature, while a clear blue sky completes the tranquil outdoor scene.
Vacation home in Fripp Island
5 out of 5 average rating, 69 reviews

Secluded Treehouse Overlooking Saltwater Marsh

Relax, decompress, and unwind up in the trees at the edge of the Atlantic in our secluded Treehouse overlooking the saltwater marsh. Panoramic floor to ceiling windows wrap around the entirety of this unique treehouse. 2 Bedroom 2 Bathroom Treehouse with 3 decks. Watch the sunrise from the comfort of the couch, nap in the comfy rope hammock, or take a cruise in the brand new golf cart included with your stay. Just a short 5 min golf cart ride to the beach. Secluded paradise is waiting for you

Top guest favorite
Vacation home in Greenville
4.93 out of 5 average rating, 194 reviews

City Dream Spacious 2BR-2BA Walk the Heart of GVL

Enjoy a last minute city escape to GVL! Enjoy 2 FULL BATHROOMS. Prime location by Main St. to walk,trolley,bike downtown or to trail. This gem is 5 min walk to Bcycle/trolley @Fluor Field.10 min walk to Falls.Uber friendly.See shops-art galleries-museums-tours-eateries-breweries-outdoor activities.Newly remodeled spacious historic bldg w 10’ ceilings, wood floors & new baths.1300 sq.ft entire 1st floor.1 King &1 Queen bed.Large private patio,full kitchen/living/dining. Games & records.PARK FREE

Guest favorite
Vacation home in Abbeville
5 out of 5 average rating, 10 reviews

The Parlor #1

After family used this unit for several years, we are back in Airbnb mode as of 12/25! Updated pics coming soon! Come relax and enjoy life in the country! Our apartment is an actual renovated milking parlor! While the dairy is no longer in operation, we have beef cattle that you may see as you sit and enjoy your coffee on the front porch! There is a one queen bed but we are ok with a couple children on floor beds or couches. Just ask! We are 6 minutes from Abbeville and 12 minutes from Due We

Guest favorite
A welcoming blue front door is set against light beige siding. Flanking the door are two decorative planters containing lush greenery. A vertical sign reading 'WELCOME' stands beside the door, enhancing the inviting entrance.
Vacation home in Roebuck
4.9 out of 5 average rating, 105 reviews

Patriot Point B, an inviting studio apartment

This patriot themed studio apartment sleeps 5. The apartment includes a queen, pull out queen sofa bed, optional roll out full bed, a full kitchen, 1 bathroom, full laundry area, with areas for relaxing, bonfire and a gas grill. The apartment offers cozy patriotic decor including several historic homes in the area. It's charming and includes a large room with designated areas for the bed and living area, a kitchen and separate bath. We are minutes from downtown Spartanburg. Kerri & Brian

Top guest favorite
Two coasters with a personalized design are placed on a detailed map of the lake area. The map displays various waterways and terrain features, inviting exploration and adventure in the surroundings.
Vacation home in Anderson
4.99 out of 5 average rating, 112 reviews

Lake House and Dock Upscale and Immaculate

Our immaculate 2020 built water-themed home is a luxury furnished lakefront 1.1 acre property on Lake Hartwell with a large boat dock. Our house enjoys amazing lake views and is perfect for the tournament fisherman, the boating enthusiast, golfers, families and those just needing to relax. We are down the street from Stonecreek Cove Golf Course in a countryside atmosphere and are comfortably close to the renowned Green Pond Landing, host to many national fishing tournaments.

Top guest favorite
A balcony offers a view of the ocean and a pool area below. Two chairs are positioned on the balcony, enhancing the outdoor space. The horizon showcases a gradient of colors as the sun sets over the water, creating a serene backdrop.
Vacation home in Myrtle Beach
4.96 out of 5 average rating, 160 reviews

Oceanfront Balcony Penthouse @ Myrtle Beach Resort

Oceanfront penthouse (top floor) in Myrtle Beach Resort. Sleeps 7+infant (pack-n-play), 6 pools (oceanfront, indoor, 4 outdoor, some closed for winter), splash park, 6 hot tubs, pickleball, basketball, tennis, cornhole, volley ball, general store/snack shop, steamrooms, saunas, fitness centers, playground, onsite laundry, beach bar, gated entrance, free cable, private high-speed Internet, keyless entry, 8 min to airport and golf, 15 min to Broadway, tons of attractions!

Superhost
A two-story house is observed with a light-colored exterior and an inviting entrance. Two patio chairs are positioned on a paved area, complemented by landscaping along the base. Large windows reflect natural light under a clear blue sky, framed by lush greenery.
Vacation home in North Myrtle Beach
4.78 out of 5 average rating, 105 reviews

Cozy House - Just a Short Walk to the Beach!

Relax with the whole family at this peaceful house located only a few blocks away from the beach with mini golf course in its back yard. Take an early morning walk to enjoy the sunrise over the ocean. The house is freshly painted with the gated pool across the street. Located a walking distance away from one of the most unique & popular shopping, dining & entertainment destinations Barefoot Landing as well as one of the biggest attractions Alligator Adventure.

Guest favorite
A large screened front porch features a mix of comfortable seating options, including two cushioned chairs and a small table. Light blue walls and natural light create a relaxed atmosphere. Decorative oars are mounted on the wall, enhancing the coastal theme of the space.
Vacation home in Surfside Beach
4.99 out of 5 average rating, 69 reviews

Pet friendly beach cottage

Pet friendly beach cottage a couple block walk from the ocean. Three bedrooms and 1 bath that comfortably sleeps 6. Recently renovated with granite countertops, new floors, and fresh paint everywhere. Large lot with plenty of room to play and run your dogs. It has a large screened front porch to sit to enjoy your morning coffee and listen to the ocean. There are 2 queen beds and 1 full bed. The kitchen is fully stocked and there is a washer and dryer.

Guest favorite
A spacious outdoor area is featured, showcasing a heated saltwater pool surrounded by lounge chairs. An umbrella provides shade, and lush greenery and trees line the background, which overlooks a serene lake. The open sky is bright with fluffy clouds.
Vacation home in Summerton
4.96 out of 5 average rating, 118 reviews

Lakefront Paradise W/Pool/hot tub/outdoor kitchen

Brand new heated saltwater pool, hot tub and outdoor kitchen area. This upgraded home is ready to host your family or large group! Enjoy breathtaking sunsets year round from your private beach directly on the big waters of Lake Marion. Spends evenings out on the dock fishing or pull your boat right up to the beach. Ping pong and bumper pool tables, fast wifi and big screen tv's make for the perfect entertaining space for large groups.

Top guest favorite
The exterior of The Betsy Surf Shack is highlighted by a welcoming porch framed by a sturdy tree. A colorful sign bearing the name 'BETSY' is displayed prominently. Lush greenery surrounds the charming home, complemented by decorative flowers near the entrance.
Vacation home in North Myrtle Beach
4.96 out of 5 average rating, 73 reviews

Hippie Hideaway-The Betsy awaits your arrival.

Just steps away from the beach, The Betsy Surf shack is a unique beach home in Windy hill. Windy hill is a quaint little hideaway in North Myrtle Beach. Our home has a lovely front porch for reading and relaxing. This home hosts two bedrooms and is pet friendly. Our back yard has a large area to enjoy sitting at the picnic table or by the fire pit. If you need a getaway with a sweet home near the beach. The Betsy Surf shack is waiting.

Guest favorite
A bright living space features a blue sofa and a television, with large glass windows showcasing the lush greenery outside. A dining area with table and chairs is visible, alongside a spiral staircase leading to an upper level, emphasizing the treehouse's unique architecture.
Vacation home in Seabrook Island
4.92 out of 5 average rating, 145 reviews

Peaceful, Pet-Friendly Treehouse w/Bikes included

Escape to our unique, pet-friendly waterfront treehouse on Seabrook Island! This updated 2-bed, 2-bath retreat offers serene lagoon views and a swing bed at the water's edge. Surrounded by nature, it's perfect for a relaxing getaway. Enjoy a short walk to the beach, community pool, and gym. Ideal for small groups or families seeking a tranquil island experience. Your private, elevated nature retreat awaits!

Superhost
Vacation home in Charleston
4.87 out of 5 average rating, 126 reviews

Downtown 4BR + Backyard Oasis | 2 Parking Spots

Experience Charleston in style at this brand-new 4BR/3BA retreat on Spring Street! Perfect for groups with a rare downtown perk: 2 dedicated parking spots plus a private outdoor lounge. Enjoy bright, modern interiors, a spacious kitchen & dining setup, and walkable access to King Street dining, nightlife, shopping, and historic Charleston charm.

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