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Guesthouse vacation rentals in Santa Cruz

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Santa Cruz

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite
Guesthouse in El Chaltén
4.87 out of 5 average rating, 38 reviews

Rio Apart

200 meters from downtown and the Laguna Torre and La Lagunita Reserve trails. Equipped for 2 people. Large room on the 1st floor, with 1 Extra King Size bed or 2 single beds of one and a half square. Private bathroom on the ground floor, WiFi. Fully equipped kitchen (extractor, burners, oven, refrigerator, coffee maker, toaster, electric kettle and water filter). Uncovered parking, bedding, towels and heating. We promote water care and waste separation practices.

Guest favorite
A wooden dining table is set with two wine glasses beside a bottle of red wine. An open fireplace is visible in the background, with flames flickering against a stone and wood interior. A bright kitchen area includes a microwave and a basket of fruits.
Guesthouse in El Calafate
4.95 out of 5 average rating, 242 reviews

Manantiales Calafate House

Large house in the Manantiales neighborhood (90 square meters) 100 meters from the main avenue and the waterfront, a 20-minute walk from downtown. Very close to the promenade for walking or cycling... Reading and recreation space exclusively for guests Beautiful park with sun loungers and chairs to enjoy sunny days... The garden also has an outdoor grill under the trees and a nice place to eat near the fire. REGISTERED accommodation.

Superhost
Private room in El Calafate
4.71 out of 5 average rating, 7 reviews

Araucaria | Central Double Room

Double room, located on the main avenue. A comfortable and quiet option, within walking distance of restaurants, bars, and excursion agencies. The room has a private bathroom, heating, WiFi, bedding and towels. There is a fully equipped shared kitchen. Check-in is self check-in, allowing you to arrive comfortably at any time. Free parking on the sidewalk in front of the property. A simple and cozy space to rest and enjoy Patagonia.

Top guest favorite
An open-plan living space is visible, featuring a wooden staircase leading to a loft area. The bright kitchen includes modern appliances and light cabinets, while a dining table with black chairs occupies the center. Large windows along the walls allow natural light to fill the room.
Guesthouse in Los Antiguos
5 out of 5 average rating, 37 reviews

Casa Valentín

Enjoy this space with vintage decor designed for a cozy stay. Ground floor: Spacious room with full kitchen, washing machine, refrigerator, indoor grill, bathroom, 1 and 1/2 square bed base with sailor bed, dining table and chairs, LED TV with Chromecast. Upper floor: Loft bedroom with a double bed base, desk and Smart TV. Front patio/garage and small backyard with slide (shared with owners). Camping chairs with portable grill.

A spacious bedroom features a large bed covered with a patterned quilt. Nightstands with orange lamps are positioned on either side of the bed. A dark wooden closet is present along one wall. The tiled floor adds texture to the room.
Guesthouse in El Calafate
4.89 out of 5 average rating, 37 reviews

Casimiro Department-New Spacious in Central Zone

Located 20 meters from Av. Del Libertador (main avenue of El Calafate), 3 blocks from the shopping center. Minimarket at 10 meters, car rental and service station at 50 meters. Hairdresser, Bakery and Coffee shop, Pharmacies, Banks, Greengrocer, Artisan Walk, Kiosks and Amphitheater in the area. Access to the Redonda Bay 200 meters.

The entrance of the apartment features a vibrant blue exterior accented by red trim. A wooden door with a decorative entryway is framed by lush greenery and colorful plants. Natural stone landscaping complements the inviting facade, creating a welcoming atmosphere.
Guesthouse in El Calafate
4.9 out of 5 average rating, 21 reviews

A charm apartment with nice garden

Certificación Safe Travels. Habilitado por la Municipalidad local e inscrito en la oficina de Turismo de Santa Cruz. Apartamento independiente con una habitación doble, baño privado externo, sala y comedor, cocina americana, equipamiento completo. Entrada privada. Hermoso jardín. Opcionalmente, productos caseros y huerto orgánico.

Guesthouse in El Calafate
New place to stay

Glacier Break: Comfort and Tranquility

Enjoy the magic of Patagonia in a place designed for rest. Our apartment combines a strategic location with the tranquility you are looking for on your vacation. The Space The room is spacious and versatile, ideal for families or friends, just a 5-minute drive to downtown El Calafate.

Guest favorite
A single-story house with a peaked roof is surrounded by fresh snow. The white exterior is complemented by wooden accents around the windows and porch. Snowflakes are visible in the air, creating a serene winter scene. Lush greenery is partially covered in snow nearby.
Guesthouse in El Calafate
4.94 out of 5 average rating, 200 reviews

Cozi guest house in a beautiful garden

Little house with two bedrooms and a kitchen with a large bathroom. Enjoy your stay in a comfortable house in a quiet neighbourhood, which has a commercial area nearby. Perfect place to rest after a long day of excursions!

A rustic exterior features a vibrant pink brick facade with a solid yellow door, complementing a window that showcases sheer white curtains. Two pink chairs are positioned nearby, and a wheelbarrow among greenery adds to the inviting outdoor space.
Guesthouse in Puerto San Julián
4.76 out of 5 average rating, 21 reviews

Guest house. Independence and privacy

Guest house with completely independent access. Located in the center of the town and 500 meters from the coast of San Julian Bay. The house is surrounded by trees and in a quiet and private environment.

Top guest favorite
Shared room in El Chaltén
5 out of 5 average rating, 18 reviews

Nomad bedbox hostel.

Nomade bedbox hostel combines the social interaction of a Hostel with the privacy and comfort of box beds. Making your experience unique in the most beautiful mountain paradise in Patagonia.

Guest favorite
Private room in El Chaltén
4.96 out of 5 average rating, 28 reviews

Double room with a private bathroom.

An economical option to enjoy a unique stay in Chalten. This is a double room with a private bathroom and separate entrance.

Private room in El Calafate
5 out of 5 average rating, 3 reviews

Triple, Mat+Sin, Centrico

A una cuadra de la zona más céntrica, restaurante al lado del hotel, traslados, servicio de lavandería, guarda equipaje.

Popular amenities for Santa Cruz guesthouse rentals